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Radix morindae officinalis saccharide polymer as well as preparation method and use thereof

A technology of Morinda officinalis sugar and Morinda officinalis sugar can be applied in the directions of drug combination, pharmaceutical formulation, medical preparation containing active ingredients, etc., which can solve the research problem of anti-osteoporosis effect of Morinda officinalis glycopolymer. See reports and other issues to achieve the effect of simple preparation process and convenient operation

Active Publication Date: 2017-09-01
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the research on Morinda officinalis at home and abroad mainly focuses on the anti-oxidation, immune regulation, and anti-osteoporosis activities of its total polysaccharide extracts. There is no report on the anti-osteoporosis effect of polymers, and there are few reports on the in vitro bone-promoting activity of refined sugar polymers isolated and purified from Morinda officinalis

Method used

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  • Radix morindae officinalis saccharide polymer as well as preparation method and use thereof
  • Radix morindae officinalis saccharide polymer as well as preparation method and use thereof
  • Radix morindae officinalis saccharide polymer as well as preparation method and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1 Morinda officinalis glycopolymer MOP-1 and preparation method thereof

[0062] Morinda officinalis glycopolymer MOP-1, after complete acid hydrolysis, methylation analysis, infrared spectrum detection and NMR analysis, such as Figure 1~6 As shown, the glycopolymer is composed of glucose and fructose, the main chain is (2→1)-β-D-Fruf, the end is glucose, and the structure is:

[0063] Where n is 1-6.

[0064] The preparation method of the Morinda officinalis glycopolymer MOP-1 is:

[0065] S1. Drying: dry the Radix Morinda officinalis of certain weight;

[0066] S2. Water extraction: Extract the dried Morinda officinalis with 10 times the volume of water at a temperature of 90° C., collect the extract, and dry the residue.

[0067] S3. Alcohol precipitation: After the extract was concentrated under reduced pressure at 60°C, ethanol was added to make the ethanol volume concentration 50%, after standing for 24 hours, centrifuged, and the precipitate was ...

Embodiment 2

[0072] Embodiment 2 Morinda officinalis glycopolymer MOP-2 and preparation method thereof

[0073] Morinda officinalis glycopolymer MOP-2, after complete acid hydrolysis, methylation analysis, infrared spectrum detection and NMR analysis, such as Figure 7-12 As shown, its monosaccharide is composed of glucose and fructose, the main chain is (2→1)-β-D-Fruf, and the end is fructan of glucose, the structure is:

[0074] Where n is 14-30.

[0075] The preparation method of the Morinda officinalis glycopolymer MOP-2 is:

[0076] S1. Drying: dry the Radix Morinda officinalis of certain weight;

[0077] S2. Water extraction: Extract the dried Morinda officinalis with 10 times the volume of water at a temperature of 90° C., collect the extract, and dry the residue.

[0078] S3. Alcohol precipitation: After the extract was concentrated under reduced pressure at 60°C, ethanol was added to make the ethanol volume concentration 50%, after standing for 24 hours, centrifuged, and the ...

Embodiment 3

[0083] Embodiment 3 Morinda officinalis glycopolymer MOP-3 and preparation method thereof

[0084] Morinda officinalis glycopolymer MOP-3, after complete acid hydrolysis, methylation analysis, infrared spectrum detection and NMR analysis, such as Figures 13 to 18 As shown, it is composed of glucose and fructose, the main chain is (2→1)-β-D-Fruf, the end is glucose, and the structure is:

[0085] wherein n is 7-13.

[0086] The preparation method of the Morinda officinalis glycopolymer MOP-3 is:

[0087] S1. Drying: dry the Radix Morinda officinalis of certain weight;

[0088] S2. Water extraction: Extract the dried Morinda officinalis with 10 times the volume of water at a temperature of 90° C., collect the extract, and dry the residue.

[0089] S3. Alcohol precipitation: After the extract was concentrated under reduced pressure at 60°C, ethanol was added to make the ethanol volume concentration 50%, after standing for 24 hours, centrifuged, and the precipitate was colle...

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Abstract

The invention belongs to the technical field of medicines and healthcare food, and particularly relates to radix morindae officinalis saccharide polymer as well as a preparation method and application thereof in preparing a medicine for controlling osteoporosis and / or rheumatism or healthcare food for functional food. A saccharide polymer pure product is obtained by taking radix morindae officinalis as a raw material through combination of water extraction and alcohol precipitation and alkaline extraction and alcohol precipitation, protein removal adopting a Sevag method, DEAE cellulose column chromatography, Sephacryl column chromatograph and the like. The radix morindae officinalis saccharide polymer has a remarkable effect in resisting osteoporosis. Besides, the saccharide polymer pure product obtained by the invention is displayed to have effects of promoting osteocytes to proliferate, differentiate, mineralize and regulate up expression amount of osteogenesis-related genes in bone formation experiment in vitro, is indicated to have the effect of promoting bone forming activity, and can provide basis for application in the fields of healthcare products, medicines and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine and health food, and in particular relates to Morinda officinalis sugar polymer and its preparation method, and its application in the preparation of medicines or health products or food for preventing and treating osteoporosis and / or rheumatism. Background technique [0002] Osteoporosis (OP) is a systemic metabolic bone disease characterized by low bone mass, damage to bone microarchitecture, and decreased bone strength, resulting in increased bone fragility and susceptibility to fracture. Osteoporosis is a common chronic bone disease in the elderly. With the aging of the population, osteoporosis has seriously endangered the health of the elderly. Postmenopausal women often suffer from osteoporosis mainly due to the reduction of estrogen secretion from their ovaries, which in turn leads to a series of reactions. They become the biggest victim of the disease, accounting for more than 70% of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P19/10A61P29/00
CPCA61K31/715C08B37/0003C08B37/006
Inventor 严春艳
Owner GUANGDONG PHARMA UNIV
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