Method for strengthening and toughening akermanite bone scaffold through cooperation of graphene and BNNT

Abstract

The invention provides a method for promoting uniform dispersion of graphene and boron nitride nanotubes (BNNT) in a basal body and strengthening and toughening an akermanite bone scaffold through cooperation of graphene and BNNT. The method has the advantages that a three-dimensional nanometer second phase is formed through combination of two-dimensional graphene and one-dimensional BNNT, mutual dispersion is promoted through synergetic support, and the problem of agglomeration when graphene or BNNT is independently used is solved; by means of the excellent mechanical property and the large specific surface areas of graphene and BNNT, the strength and the toughness of the akermanite bone scaffold are improved through pull-out effect and crack deflection; due to the fact that graphene and BNNT can induce osteogenic differentiation of stem cells, the osteogenic capability of the akermanite bone scaffold is further improved.

Description

technical field [0001] The invention relates to a method for utilizing the synergistic effect of graphene and boron nitride nanotubes to promote their uniform dispersion and strengthen the feldspar bone scaffold, which belongs to the field of biomanufacturing. Background technique [0002] As a silicate bioactive ceramic, magnesian feldspar (Ca 2 MgSi 2 o 7 ) has moderate degradation stability and the ability to induce apatite formation. Compared with traditional calcium phosphate ceramics, magnesian feldspar ceramics also exhibit better cytocompatibility, cell activity and in vitro osteogenic induction. It supports the adhesion, proliferation, differentiation and gene expression of various cells, and the released ion products containing Ca, Si and Mg can significantly stimulate the proliferation and osteogenic differentiation of various stem cells. Further research found that feldspar ceramics can not only induce the growth of new bone, but also promote the formation of ...

AI Technical Summary

Problems solved by technology

However, a series of studies have shown that graphene or BNNT-reinforced feldspar composite bone scaffolds did not achieve the expected high strength and high toughness, mainly due to the strong van der Waals force between graphene and BNNT. Coupled with the lack of functional sites on its surface, graphene and BNNT are prone to agglomeration and difficult to uniformly and stably disperse in the ceramic matrix, resulting in weak interface bonding between low-dimensional nanomaterials and the ceramic matrix and even defects. The effect of improving the mechanical properties of the stent is very limited

[0004] In order to further develop the strengthening and toughening potential of graphene and BNNT, some scholars added functional sites on the surface through covalent bond modification to improve their dispersion state and interfacial binding state in the matrix. However, strong acid in the process of covalent bond modification Or the strong alkaline environment will also bring serious structural damage to low-dimensional nanomaterials, thereby reducing their original excellent properties.