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Composite wound restoration dressing based on mussel mucoprotein and polylactic acid microspheres, and preparation method and application thereof

A technology of polylactic acid microspheres and mussel mucin is applied in the field of medical materials to achieve the effects of excellent biocompatibility, good antibacterial properties and simple equipment

Inactive Publication Date: 2017-08-11
苏州医甸园医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of biological dressings, but none of them has the functions of antibacterial, promoting wound healing, and providing trace elements and nutrition at the same time.

Method used

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  • Composite wound restoration dressing based on mussel mucoprotein and polylactic acid microspheres, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of mussel mucin solution: Take 1ml of mussel mucin solution (80mg of mussel mucin), add 10ul of calcium acetate solution (9mg of calcium acetate) at room temperature, fully mix the mussel mucin and calcium acetate solution, add SPDP (5 mg) solution was cross-linked at room temperature for 4 hours, then collagen (5 mg) was added to the cross-linked protein solution, stirred thoroughly to mix evenly, diluted with normal saline, and the concentration of mussel mucin solution made was 0.5 mg / ml .

[0029] Obtain or prepare drug-loaded PLA microspheres: prepare ciprofloxacin polylactic acid microspheres by emulsification-solvent evaporation method, dissolve 0.6g polylactic acid in 10ml dichloromethane, and disperse ciprofloxacin and 6mg titanium dioxide in Among them, at a stirring speed of 1000rpm, slowly add to the dispersion medium (PVA solution) (5.0%), emulsify for a certain period of time, and then pour into the diffusion medium (low concentration PVA solut...

Embodiment 2

[0032]Preparation of mussel mucin solution: Take 1ml of mussel mucin solution (97mg of mussel mucin), add 15ul of manganese oxide solution (5mg of manganese oxide) at room temperature, fully mix the mussel mucin and manganese oxide solution, add Glutaraldehyde (1 mg) solution was cross-linked at room temperature for 4 hours, and then chitosan (1 mg) was added to the cross-linked protein solution, stirred thoroughly to mix evenly, diluted with normal saline, and the concentration of the mussel mucin solution made was 0.5 mg / ml.

[0033] Obtain or prepare drug-loaded PLA microspheres: prepare ciprofloxacin polylactic acid microspheres by emulsification-solvent evaporation method, dissolve 0.6g polylactic acid in 10ml dichloromethane, and disperse ciprofloxacin and 6mg titanium dioxide in Among them, at a stirring speed of 1000rpm, slowly add to the dispersion medium (PVA solution) (5.0%), emulsify for a certain period of time, and then pour into the diffusion medium (low concent...

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Abstract

The invention discloses a composite wound restoration dressing based on mussel mucoprotein and polylactic acid microspheres, and a preparation method and an application thereof. The composite wound restoration dressing based on mussel mucoprotein and polylactic acid microspheres is obtained through mixing the mussel mucoprotein with the polylactic acid microspheres. The obtained novel restoration dressing has extremely strong adhesion, can be widely adhered to the surfaces of wounds, has very good biocompatibility and degradability, has no toxic or harmful effects on human bodies, and can accelerate the healing of the wounds.

Description

technical field [0001] The invention relates to a medical material, in particular to a composite wound repair dressing based on mussel mucin and polylactic acid microspheres, a preparation method and application thereof. Background technique [0002] The main function of medical dressings is to cover and protect damaged skin, and at the same time provide an environment conducive to wound healing. Natural mussel-like protein (MAP) is an adhesive protein extracted from mussel foot silk, which is rich in dopamine (DOPA). However, the sterilization level of mussel mussel protein can only reach bacteriostasis, not sterilization , Sterilization, not suitable for severely infected wounds. Polylactic acid is a high molecular polymer, which has been widely used in immunology, gene therapy, tumor therapy, ophthalmology and many other medical fields, but it has not been developed and applied in the field of skin and mucous membrane wound repair. At present, there are many kinds of bi...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/26A61L15/42A61L15/64A61L15/46A61L15/48A61L15/44A61L15/24
CPCA61L15/32A61L15/24A61L15/26A61L15/42A61L15/44A61L15/46A61L15/48A61L15/64A61L2300/252A61L2300/402A61L2300/404A61L2300/412A61L2300/414A61L2300/602C08L67/04C08L33/12
Inventor 宋智谦
Owner 苏州医甸园医疗科技发展有限公司
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