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High-strength chemical-physical dual-network hydrogel with self-recovery capability, and preparation method and application of hydrogel

A hydrogel and self-recovery technology, which is applied in the fields of medical preparations of non-active ingredients, medical science, and pharmaceutical formulations, can solve the problems of low gel fracture energy and decreased mechanical properties, and achieve simple preparation process and recovery of mechanical properties. Performance, Effect of Good Fatigue Resistance

Inactive Publication Date: 2017-08-04
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fracture energy of the gel obtained by this method is low, and the mechanical properties drop sharply in the case of gaps

Method used

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  • High-strength chemical-physical dual-network hydrogel with self-recovery capability, and preparation method and application of hydrogel
  • High-strength chemical-physical dual-network hydrogel with self-recovery capability, and preparation method and application of hydrogel
  • High-strength chemical-physical dual-network hydrogel with self-recovery capability, and preparation method and application of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] (1) Weigh 50 mg of chitosan, 15 mg of the first cross-linking agent N,N'-methylenebisacrylamide, and 2-hydroxy-4-(2-hydroxyethoxy)-2-methylbenzene as the initiator Acetone 5mg, hydrophilic monomer acrylamide 800mg, then add 10mL of water, evenly mix and dissolve to obtain a mixed solution; pour this mixed solution into a glass mold, and irradiate it under a 100-watt UV lamp for 30 minutes to obtain the first chemical network hydrogels;

[0058] (2) Then, 20 g of potassium chloride was dissolved in 100 mL of water to prepare a second crosslinking agent solution. After soaking the first chemical network hydrogel in KCl solution for 2 hours, the gel changed from transparent to opaque chemical-physical dual network hydrogel.

[0059] The obtained chemical-physical double network hydrogel was tested, the compressive strength was 150MPa, the compressive deformation rate was over 99%, the tensile strength was 5.05MPa, and the elongation at break was 886%. The gel can be rest...

Embodiment 2

[0062] (1) Weigh 75 mg of chitosan, 10 mg of the first cross-linking agent N,N'-methylenebisacrylamide, 5 mg of ammonium persulfate initiator, 1000 mg of hydrophilic monomer acrylic acid, and then add 10 mL of water, uniformly Mix and dissolve to obtain a mixed solution; pour the mixed solution into a glass mold, and heat it in a water bath at 60°C for 5 hours to obtain a first chemical network hydrogel;

[0063] (2) Then, 20 g of magnesium nitrate was dissolved in 100 mL of water to prepare a second crosslinking agent solution. After soaking the first chemical network hydrogel in magnesium nitrate solution for 4 hours, the gel changed from transparent to opaque chemical-physical dual network hydrogel.

[0064] The obtained chemical-physical double network hydrogel was tested, and the compressive strength was 180MPa, the compressive deformation rate was over 99%, the tensile strength was 6.05MPa, and the elongation at break was 736%. The gel can be restored to its original te...

Embodiment 3

[0066] (1) Weigh 40 mg of chitin, 15 mg of the first cross-linking agent N,N'-methylenebisacrylamide, 3.5 mg of the initiator α-ketoglutaric acid, and the hydrophilic monomer methacrylic acid N,N- 1200 mg of dimethylaminoethyl ester, then 10 mL of water was added, and the mixture was uniformly mixed and dissolved to obtain a mixed solution; the mixed solution was poured into a glass mold and irradiated under a 150-watt UV lamp for 40 minutes to obtain the first chemical network hydrogel ;

[0067] (2) Then, 1.5 g of sodium hydroxide was dissolved in 100 mL of water to prepare a second crosslinking agent solution. The first chemical network hydrogel was soaked in sodium hydroxide solution for 5 hours, and the gel changed from transparent to translucent chemical-physical dual network hydrogel.

[0068] The obtained chemical-physical double network hydrogel was tested, and the compressive strength was 160 MPa, the compressive deformation rate was over 99%, the tensile strength was...

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Abstract

The invention discloses high-strength chemical-physical dual-network hydrogel with self-recovery capability, and a preparation method and application of the hydrogel. The high-strength chemical-physical dual-network hydrogel with the self-recovery capability is prepared from a first chemical network formed by the polymerization of hydrophilic monomers or by enabling hydrophilic macromolecules to be mixed and have a reaction, and a second physical network formed by carrying out physical crosslinking on polysaccharide and derivatives thereof, wherein the first chemical network and the second physical network are arranged in a way of being interspersed with each other. The dual-network hydrogel has high compressive strength and tensile strength, high toughness as well as good self-recovery property and fatigue resistance, and can maintain higher tensile strength and breakage elongation under the condition of having a notch. The prepared hydrogel has good mechanical property and biocompatibility, can be widely applied to the field of biological medicine, and can be used as a surface coating of a scaffold for tissue engineering, medical sponge or a medical implant.

Description

technical field [0001] The invention relates to a double network hydrogel, in particular to a high-strength chemical-physical double network hydrogel with self-recovery ability and a preparation method and application thereof. Background technique [0002] A hydrogel is a soft substance that can absorb a lot of water and has a three-dimensional network structure. Hydrogels are widely used in biomedical, agricultural, industrial, environmental protection and other fields due to their high water absorption and good biocompatibility. In terms of biomedicine, hydrogels have been used in drug carriers, cell carriers, dressings, facial masks, and artificial corneas. However, for load-bearing soft tissues such as cartilage, tendon and ligament, traditional hydrogels cannot meet the requirements. [0003] Natural polysaccharides and their derivatives originate from nature, with abundant resources, wide sources, and easy access. With their excellent biocompatibility and degradabili...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/26C08L33/02C08L33/14C08L33/24C08L5/08C08L5/00C08L71/02C08L5/04C08K3/16C08K3/28C08K3/22C08K3/30C08K5/098C08J3/24C08J3/075C08F220/56C08F220/06C08F220/34C08F220/28C08F222/38C08F220/54C08F2/48
CPCA61K9/06A61K47/32A61K47/34A61K47/36A61L27/16A61L27/18A61L27/20A61L27/52A61L31/042A61L31/048A61L31/06A61L31/10A61L31/145A61L2420/06C08F2/48C08F220/06C08F220/28C08F220/281C08F220/34C08F220/54C08F220/56C08J3/075C08J3/243C08L33/02C08L33/14C08L33/24C08L33/26C08L71/02C08L2203/02C08L2205/025C08L2205/03C08L2205/04C08F222/385C08L5/08C08K3/16C08K3/28C08K3/22C08K2003/3063C08L5/00C08K5/098C08L5/04C08K2003/162
Inventor 吴德成杨艳宇王星杨飞
Owner INST OF CHEM CHINESE ACAD OF SCI
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