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Transdermal-absorption preparation containing compound cortex phellodendri liquid and preparing method and application of transdermal-absorption preparation

A technology of transdermal absorption preparation and compound Phellodendron liquid, which is applied in the field of medicine and can solve problems such as research on the transdermal behavior of compound Phellodendron liquid

Active Publication Date: 2017-07-28
NO 411 HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is no research on the in vitro transdermal behavior of Compound Cortex Phellodendri

Method used

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  • Transdermal-absorption preparation containing compound cortex phellodendri liquid and preparing method and application of transdermal-absorption preparation
  • Transdermal-absorption preparation containing compound cortex phellodendri liquid and preparing method and application of transdermal-absorption preparation
  • Transdermal-absorption preparation containing compound cortex phellodendri liquid and preparing method and application of transdermal-absorption preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Instruments and materials

[0027] 1.1 Instrument

[0028] High-performance liquid chromatography (Shimadzu LC-10AT, SPD-10AVP ultraviolet-visible spectrum detector); Drug transdermal diffusion test instrument (Changhai Hospital); Diffusion cell (Shanghai Yuyan Scientific Instrument Co., Ltd.); 1 / 100,000 Electronic analytical balance (METTLER TOLEDO XP105DR); 1ml pipette gun (Jiangsu Shengaohua Environmental Protection Technology Co., Ltd.); hydrophilic PTFE needle filter (pore size 0.45μm) (Shanghai Anpu Scientific Instrument Co., Ltd.); pH 2 acidity meter (Shanghai Tianda Instrument Co., Ltd.).

[0029] 1.2 Reagents and materials

[0030]Compound Cortex Phellodendron (Shandong Hanfang Pharmaceutical Co., Ltd., batch number 131212); Berberine hydrochloride standard substance (86.7%, China Institute for Food and Drug Control, 110713-201212); Potassium dihydrogen phosphate (Jiangsu Yonghua Fine Chemicals Co., Ltd., batch number 130608); Sodium heptanesulfonate (Sha...

Embodiment 2

[0080] We used several other transdermal absorption enhancers at the same time during the research process, one of which is shown below as an example.

[0081]Prepare following sample according to the relevant operating method identical with embodiment 1, test the impact on the transdermal absorption effect of compound cortex cortex liquid:

[0082] ① Improve the prescription by adding camphor alone: ​​take 1g camphor and add 4ml Tween 80 for grinding, then add the compound Cortex Phellodendron solution to 100ml while stirring, and you get it.

[0083] ②Improved prescription by compound addition of borneol and camphor: Mix 0.5g borneol and 0.5g camphor and grind thoroughly, add 4ml Tween 80 after melting, grind again, add compound Phellodendron phellodendron solution to 100ml while stirring, and get ready.

[0084] Table 6 shows the results of transdermal absorption experiments of the above two improved preparations.

[0085] Table 6 Cumulative penetration of berberine hydroc...

Embodiment 3

[0088] During the research process, we investigated the effects of different concentrations of borneol and menthol on the transdermal absorption effect of the compound Phellodendron cortex liquid. The relevant operation method of this experiment is the same as that of Example 1. The results are shown in Table 7.

[0089] Table 7 Cumulative permeation of berberine hydrochloride in improved prescription preparations at different concentrations of borneol / menthol

[0090]

[0091] In the research of the present invention, the inventor constantly overcomes many difficulties. It is often difficult to select the measurement indicators when performing transdermal experiments on compound preparations of traditional Chinese medicine for external use. Not only because of the complexity of traditional Chinese medicine compound preparations, but also often difficult to detect because of the small amount of penetration. Because Cortex Phellodendri is the main drug of this prescription...

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Abstract

The invention relates to a transdermal-absorption preparation containing compound cortex phellodendri liquid and a preparing method and application of the transdermal-absorption preparation. The transdermal-absorption preparation comprises the compound cortex phellodendri liquid, borneol and menthol. The transdermal-absorption preparation can be used to prepare infection-preventing drugs and can be prepared into a lotion, an aerosol, paste or gel and the like. The transdermal-absorption preparation has the advantages that the borneol and the menthol can have a synergic effect, the transdermal-absorption rate of the drug effective component berberine hydrochloride can be enhanced evidently, the effects of clearing away heat and toxic materials and relieving swelling and removing necrotic tissue of the compound cortex phellodendri liquid are increased, and drug bioavailability is further increased.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound cortex cortex liquid transdermal absorption preparation and its preparation method and application. Background technique [0002] Compound Phellodendron Phellodendron Liquid is a national Class III new drug approved by the Ministry of Health of the People's Republic of China. It is a national eighth five-year plan development project. Xia. The latest clinical application progress of compound Huangbai liquid[J]. Chinese Journal of New Drugs, 2014,23(3):308-312]. Compound Cortex Phellodendron is composed of Phellodendron Phellodendri, Forsythia, Honeysuckle, Dandelion and Centipede five traditional Chinese medicines, among which Cortex Phellodendron is the king drug. It is a lotion, and its usage is to soak gauze strips in the medicinal liquid and apply it externally to infected wounds or ulcerated abscesses. If the ulcer is deep, a sterile rubber tube with a diameter ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K47/26A61P29/00A61K31/045A61K35/648A61K9/08A61K9/12A61K9/06
CPCA61K9/0014A61K9/06A61K9/08A61K9/12A61K31/045A61K35/648A61K36/288A61K36/355A61K36/634A61K36/756A61K47/26A61K2300/00
Inventor 吴杲吴汉斌潘勇华吴淑勰
Owner NO 411 HOSPITAL OF PLA
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