Breviscapine/chitosan composite hydrogel restraining cicatrization and preparation method thereof

A technology of compounding hydrogel and breviscapine, which is used in pharmaceutical formulation, pharmaceutical science, drug delivery and other directions to achieve the effects of improving plasticity and dispersibility, inhibiting proliferation and efficient scar formation

Active Publication Date: 2017-07-21
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of the above-mentioned prior art, aiming at the skin trauma caused b...

Method used

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  • Breviscapine/chitosan composite hydrogel restraining cicatrization and preparation method thereof
  • Breviscapine/chitosan composite hydrogel restraining cicatrization and preparation method thereof
  • Breviscapine/chitosan composite hydrogel restraining cicatrization and preparation method thereof

Examples

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Effect test

Embodiment 1

[0052] 1. Preparation of breviscapine / chitosan composite hydrogel

[0053] (1) This example provides a breviscapine / chitosan composite hydrogel that inhibits scar formation, which is prepared from chitosan, chitosan oligosaccharides, breviscapine, polyvinyl alcohol and soluble starch, each The dosage of components is: chitosan (10KDa) 2g, chitosan oligosaccharide (3KDa) 0.3g, scutellarin 2g, polyvinyl alcohol 5g, soluble starch 1g.

[0054] (2) Preparation method

[0055] According to the above quality, the raw materials of each component are respectively selected for use, and the scutellarin / chitosan composite hydrogel is prepared. The specific method includes the following steps:

[0056] S1. Pipette 1mL of glacial acetic acid into a 1L volumetric flask, add deionized water to prepare a 1% acetic acid solution; weigh 2g of chitosan with a molecular weight of 10KDa and a deacetylation degree of 85% and dissolve it in the above acetic acid solution In, stir 30min under the r...

Embodiment 2

[0067] 1. Preparation of breviscapine / chitosan composite hydrogel

[0068] This embodiment provides a breviscapine / chitosan composite hydrogel that inhibits scar formation, which is prepared from chitosan, chitosan oligosaccharide, breviscapine, polyvinyl alcohol and soluble starch, and the dosage of each component is : Chitosan (20KDa) 2g, chitooligosaccharide (2KDa) 0.3g, scutellarin 1.5g, polyvinyl alcohol 5g, soluble starch 0.8g.

[0069] For the specific preparation method, refer to Example 1, which will not be repeated here.

[0070] 2. Test experiment of breviscapine / chitosan composite hydrogel

[0071] (1) Properties test of breviscapine / chitosan composite hydrogel

[0072] Figure 4 The scanning electron microscope image of the dried scutellarin / chitosan composite hydrogel prepared for this example shows that the hydrogel has a dense porous structure. When water is contained, these pore-like structures can store water. When the voids of the hydrogel are filled wit...

Embodiment 3

[0076] 1. Preparation of breviscapine / chitosan composite hydrogel

[0077] This embodiment provides a breviscapine / chitosan composite hydrogel that inhibits scar formation, which is prepared from chitosan, chitosan oligosaccharide, breviscapine, polyvinyl alcohol and soluble starch, and the dosage of each component is : Chitosan (10KDa) 1.5g, chitooligosaccharide (300Da) 0.1g, scutellarin 1g, polyvinyl alcohol 5g, soluble starch 0.8g.

[0078] For the specific preparation method, refer to Example 1, which will not be repeated here.

[0079] 2. Test experiment of breviscapine / chitosan composite hydrogel

[0080] (1) Properties test of breviscapine / chitosan composite hydrogel

[0081] Figure 6 The scanning electron microscope image of the dried scutellarin / chitosan composite hydrogel prepared for this example shows that the hydrogel has a dense porous structure. When water is contained, these pore-like structures can store water. When the voids of the hydrogel are filled wi...

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to breviscapine/chitosan composite hydrogel restraining cicatrization and a preparation method thereof. The hydrogel is formed by compositing breviscapine, chitosan, polyvinyl alcohol and soluble starch. Due to the synergistic effect of the breviscapine and the chitosan and the effective combination of the chitosan with the high molecular weight and the chitosan with the low molecular weight, the composite hydrogel can rapidly heal a wound, has the advantages of achieving hemostasis and bacteriostat and restraining cicatrization from the source, and can shorten the blood coagulation time, accelerate wound healing and reduce cicatrization. The preparation method of the hydrogel is simple, rapid, convenient and high in practicability, the adopted high molecular materials are non-toxic and biodegradable materials, and the obtained composite hydrogel has the advantages of being good in biocompatibility, good in biodegradability, good in absorptivity, safe, non-toxic and the like, and has the good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials. More specifically, it relates to a breviscapine / chitosan composite hydrogel for inhibiting scar formation and a preparation method thereof. Background technique [0002] Scar is the disorder of fibroblast proliferation in the skin dermis, resulting in excessive production of fibroblasts and excessive deposition of collagen. It is a common complication after skin trauma and surgery, and seriously affects the appearance and psychology of patients. The pathogenesis of scar and its prevention and treatment methods have always been a research hotspot in the medical field, and there is no clear conclusion on its pathogenesis. Scar is the product of skin wound repair and healing process. Except for superficial wounds that can be repaired by simple epithelial formation, any damage that reaches deep into the dermis and subcutaneous tissue will be repaired by scar formation. Theoretically sp...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0066A61L26/008A61L26/009A61L2300/232A61L2300/40A61L2300/404A61L2400/04C08L3/02C08L5/08C08L29/04
Inventor 李思东欧阳茜茜胡章陈法锦黄娜孔松芝李普旺李永振潘江球李高荣
Owner GUANGDONG OCEAN UNIVERSITY
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