A bio-3D printed skin repair scaffold
A 3D printing and skin repair technology, applied in tissue regeneration, prosthesis, additive processing, etc., can solve problems such as large differences in physical properties and biological activities, complex and single components, etc., to speed up wound healing and facilitate blood vessel growth. and cell adhesion growth
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Embodiment 1
[0053] A biological 3D printing skin repair scaffold, comprising an epidermis layer, a dermis layer and a subcutaneous tissue layer successively superimposed in the form of hydrogel;
[0054] The hydrogel composition of the epidermal layer includes sodium alginate 20mg / ml, gelatin 18mg / ml, collagen 5mg / ml, hyaluronic acid 2mg / ml, elastin 1mg / ml, laminin 1mg / ml, glycerin 80mg / ml, KGF 5ng / ml; the hydrogel composition of the dermis includes sodium alginate 15mg / ml, gelatin 20mg / ml, collagen 10mg / ml, glycerin 60mg / ml, hyaluronic acid 5mg / ml, FGF 10ng / ml; the hydrogel composition of the subcutaneous tissue layer includes sodium alginate 10mg / ml, gelatin 20mg / ml, collagen 4mg / ml, hyaluronic acid 2mg / ml, VEGF 1.0ng / ml; the mg / ml Refers to the mass volume ratio of the corresponding components to the prepared PBS solution.
[0055] The preparation method of the hydrogel of the epidermis is as follows: dissolve hyaluronic acid in PBS, stir for 4 hours to dissolve and mix well, then a...
Embodiment 2
[0063] A biological 3D printing skin repair scaffold, comprising an epidermis layer, a dermis layer and a subcutaneous tissue layer successively superimposed in the form of hydrogel;
[0064] The hydrogel composition of the epidermal layer includes sodium alginate 25mg / ml, gelatin 15mg / ml, collagen 10mg / ml, hyaluronic acid 1mg / ml, elastin 0.1mg / ml, laminin 0.1mg / ml, Glycerin 50mg / ml, KGF 1ng / ml; the hydrogel composition of the dermis includes sodium alginate 20mg / ml, gelatin 18mg / ml, collagen 1mg / ml, hyaluronic acid 5mg / ml, glycerin 50mg / ml, FGF 10ng / ml; the hydrogel composition of the subcutaneous tissue layer includes sodium alginate 15mg / ml, gelatin 25mg / ml, collagen 1mg / ml, hyaluronic acid 1mg / ml, VEGF 0.1ng / ml.
[0065] The preparation method of the hydrogel of the epidermis, the hydrogel of the dermis, and the hydrogel of the subcutaneous tissue layer is the same as that of Example 1.
[0066] The 3D printing method of described a kind of biological 3D printing skin rep...
Embodiment 3
[0072] A biological 3D printing skin repair scaffold, comprising an epidermis layer, a dermis layer and a subcutaneous tissue layer successively superimposed in the form of hydrogel;
[0073] The hydrogel composition of the epidermis comprises sodium alginate 25mg / ml, gelatin 15mg / ml, collagen 15mg / ml, hyaluronic acid 3mg / ml, elastin 5mg / ml, laminin 5mg / ml, glycerol 100mg / ml, EGF 10ng / ml; the hydrogel composition of the dermis includes sodium alginate 20mg / ml, gelatin 20mg / ml, collagen 10mg / ml, glycerin 80mg / ml, hyaluronic acid 2mg / ml, FGF 20ng / ml; the hydrogel composition of the subcutaneous tissue layer includes sodium alginate 18mg / ml, gelatin 15mg / ml, collagen 10mg / ml, hyaluronic acid 1mg / ml, VEGF 1.0ng / ml.
[0074] The preparation method of the hydrogel of the epidermis, the hydrogel of the dermis, and the hydrogel of the subcutaneous tissue layer is the same as that of Example 1.
[0075]The 3D printing method of described a kind of biological 3D printing skin repair ...
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