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Supermolecular compound, preparation method thereof, and method used for distinguishing microorganisms

A technology of supramolecular compounds and conjugated polymers, which can be used in the determination/inspection of microorganisms, biochemical equipment and methods, etc., can solve the problem of inability to efficiently and quickly distinguish the types of microorganisms, and achieve improved treatment efficiency, efficient integration, and broad application. Foreground effect

Active Publication Date: 2017-07-14
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to overcome the defect that the existing technology cannot efficiently and quickly distinguish the types of microorganisms, and provides a supramolecular compound and its preparation method and a method for distinguishing microorganisms

Method used

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  • Supermolecular compound, preparation method thereof, and method used for distinguishing microorganisms
  • Supermolecular compound, preparation method thereof, and method used for distinguishing microorganisms
  • Supermolecular compound, preparation method thereof, and method used for distinguishing microorganisms

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preparation example Construction

[0049] The present invention also provides a kind of preparation method of supramolecular compound, and this method comprises the following steps:

[0050] (1) providing or preparing a conjugated polymer having a structure as shown in formula (I);

[0051] (2) Contacting the conjugated polymer described in step (1) with cucurbit[7]uril.

[0052] In the present invention, the conjugated polymer with the structure represented by formula (I) can be prepared according to the method provided in the present invention, or can be obtained by other methods, and there is no specific limitation. For example, you can refer to the synthetic methods in the literature: Xing, C.F.; Yang, G.M.; Liu, L.B.; Yang, Q.; Lv, F.T.; Wang, S., Conjugated Polymers for Light-Activated Antifungal Activity. ), 525-529.

[0053] According to the preparation method of the supramolecular compound of the present invention, in step (2), the conditions of the contact are not particularly limited, as long as th...

Embodiment 1

[0079] This embodiment is used to illustrate the preparation method of the conjugated polymer of structure shown in formula (I)

[0080]Synthesis of compound 3-(2-(6-bromohexyloxy)ethyl)thiophene: Add 2-(3-thiophene)ethanol (663μL, 6mmol), sodium hydride (206mg, 6mmol), 50mL anhydrous Water DMF (dimethylformamide), the reaction solution was stirred at room temperature for 30 min under a nitrogen atmosphere; then 1,6-dibromohexane (4.6 mL, 10 mmol) was added to continue stirring overnight (15 hours), and poured into water after the reaction stopped. and extracted with dichloromethane, combined organic phases, washed with distilled water, dried over anhydrous magnesium sulfate, filtered, concentrated; the crude product was separated and purified by silica gel column chromatography, and the developing solvent was petroleum ether / ethyl acetate (40 / 1, v / v ) to give a white powder (0.54 g, 31%). 1 H NMR (400MHz, CDCl 3 )7.37(m,1H),7.15-7.10(m,2H),3.76(t,2H),3.57(t,2H),3.53(t,2H),3...

Embodiment 2

[0084] This embodiment is used to illustrate the preparation method of supramolecular compound of the present invention

[0085] Mix 1 mg of dry conjugated polymer PT and 40 mg of dry cucurbit[7]urea (CB[7]) solids and dissolve them in 3.3 mL of ultrapure water, stir at room temperature in the dark until they are completely dissolved, and obtain a final concentration of 0.2 mM PT / CB[7] in water.

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Abstract

The invention belongs to the field of supermolecular compound, and discloses a supermolecular compound, a preparation method thereof, and a method used for distinguishing microorganisms. The supermolecular compound possesses an inclusion complex structure composed of a conjugated polymer with a structure represented by formula (I), and cucurbituril [7], wherein R1 is used for representing one of structures represented by formula (II), formula (III), or formula (IV), n is used for representing an integer ranging from 30 to 300, R2, R3, and R4 are independently used for representing C1-C5 alkyl, Y is used for representing an alkylene with 6 to 12 carbon atoms, or one group with a general structure of -R5-O-R6- or -OR7-, R5, R6, and R7 are used for representing alkylenes, the carbon atom number of R7 ranges from 6 to 12, and X is used for representing a halogen. The method is high in speed, efficiency, and accuracy, and is convenient in distinguishing microorganisms such as bacteria, fungus, and virus.

Description

technical field [0001] The invention relates to the field of supramolecular compounds, in particular to a supramolecular compound and a preparation method thereof, a supramolecular compound prepared by the method, and a method for distinguishing microorganisms. Background technique [0002] The problem of drug resistance of pathogenic bacteria has become an urgent global problem that threatens human security. It has been proven that the misuse and abuse of fungicides in the fields of health care, agriculture and animal husbandry have led to the widespread emergence of drug-resistant pathogenic bacteria. For example, less than 20 percent of upper respiratory tract infections are caused by bacteria, yet patients often expect to be treated with antibiotics to which they are completely ineffective. Clinically, when a doctor diagnoses an infectious disease, the first thing to find out is whether it is caused by a bacterial or viral infection. But even for experienced doctors an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00C12Q1/70C12Q1/04
Inventor 王树白昊天吕凤婷刘礼兵
Owner INST OF CHEM CHINESE ACAD OF SCI
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