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A manganese-based coordination compound with antitumor activity

A technology of coordination compounds and anti-tumor activity, which is applied in the field of preparation of coordination compounds to achieve good anti-tumor activity and simple synthesis method

Inactive Publication Date: 2019-05-21
FUJIAN MEDICAL UNIV
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  • Abstract
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Problems solved by technology

Chemotherapy drugs such as cisplatin have serious adverse reactions, such as nephrotoxicity, neurotoxicity, bone marrow suppression, etc. However, the use of such drugs still appears in the treatment plan of more than 50% of cancer patients

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  • A manganese-based coordination compound with antitumor activity
  • A manganese-based coordination compound with antitumor activity
  • A manganese-based coordination compound with antitumor activity

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Embodiment Construction

[0019] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.

[0020] Dissolve 2.05 mmol of 2,6-pyridinedicarboxylic acid and 1.2 mmol of manganese acetate tetrahydrate in 5 mL of deionized water respectively, then mix them evenly, put them into a stainless steel reaction kettle lined with polytetrafluoroethylene, and keep at 120°C After 5 days of constant temperature reaction, the temperature was naturally lowered, filtered and rinsed with deionized water, and then dried to obtain colorless columnar crystals, which were manganese-based coordination compounds [Mn(C 7 h 3 NO 4 )] H 2 O, the yield is about 34% (calculated as Mn).

[0021] 1. [Mn(C 7 h 3 NO 4 )] H 2 Characterization of O single crystals

[0022] a. The X-ray single crystal diffraction experiment of coordination co...

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Abstract

The invention discloses a manganese-based coordination compound with anti-tumor activity. The chemical formula of the manganese-based coordination compound with anti-tumor activity is [Mn(C7H3NO4)*H2O; the molecular weight is 244.04; the manganese-based coordination compound is of a zero-dimenstional structure, and belongs to monoclinic system; space group is C2 / c; single cell parameters a=13.214(3) angstroms, b=9.7286 (19) angstroms, c=13.174(3) angstroms, alpha=gamma=90 DEG, beta=96.35(3) DEG, V=1683.2(6) angstrom<3>, and Z=8. The manganese-based coordination compound is prepared taking manganese acetate tetrahydrate and 2,6-pyridinedicarboxylic acid as raw materials via hydrothermal method. The preparation method is simple; cost is low; the obtained manganese-based coordination compound possesses excellent inhibition effect on chronic granulocytic leukemia cell strain K562 and esophageal carcinoma cell strain OE-19, and it is promising to prepare anti-tumor drugs from the manganese-based coordination compound.

Description

technical field [0001] The invention belongs to the field of coordination compound preparation, and in particular relates to a manganese-based coordination compound with antitumor activity, a preparation method and application thereof. Background technique [0002] Coordination chemistry is a branch of inorganic chemistry, which was proposed and established in 1893 by the Swiss chemist "father of coordination chemistry" Werner. Since Werner won the Nobel Prize in Chemistry in 1913, the theory of coordination chemistry has gradually matured after more than a hundred years of development, especially the crystal field theory, coordination field theory, molecular orbital theory and valence bond theory. Given a reasonable explanation, coordination chemistry has always been a frontier field in inorganic chemistry research, providing a good theoretical basis for the development of complexes on novel functional materials. Due to the diversity of the composition and the controllabil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F13/00A61P35/00A61P35/02
CPCC07F13/005
Inventor 孙伟明康杰李祥辉郭林峰
Owner FUJIAN MEDICAL UNIV
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