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Folic acid targeted magnetic functionalized molybdenum disulfide medicine carrier and preparation method thereof

A molybdenum disulfide, magnetic functionalization technology, applied in pharmaceutical formulations, drug combinations, drug delivery, etc., can solve the problems of low targeting efficiency, insufficient biocompatibility, lack of controllable release, etc., and achieve controllable operation process. , reduce the toxic and side effects of anti-tumor drugs, and improve the effect of drug loading

Inactive Publication Date: 2017-06-09
HEBEI UNIV OF ENG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the current drug carriers have made important progress in improving drug solubility and prolonging blood circulation time, the low targeting efficiency, insufficient drug loading, insufficient biocompatibility and lack of controlled release greatly limit the ability of targeted drugs. Further applications of vectors in the field of cancer therapy

Method used

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  • Folic acid targeted magnetic functionalized molybdenum disulfide medicine carrier and preparation method thereof
  • Folic acid targeted magnetic functionalized molybdenum disulfide medicine carrier and preparation method thereof
  • Folic acid targeted magnetic functionalized molybdenum disulfide medicine carrier and preparation method thereof

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preparation example Construction

[0032] Its preparation method comprises the following steps:

[0033] (1) Preparation of magnetically functionalized molybdenum disulfide nanosheets

[0034] Add molybdenum disulfide powder into deionized water, ultrasonically oscillate for 0.5-12 hours, completely dissolve the ferric salt and divalent M salt in proportion to the deionized water, stir it evenly with nitrogen bubbling method, and then raise the temperature to 60°C , gradually add alkaline regulator dropwise to make the pH of the reaction system 10-14, react for 0.5-2h, heat to 90°C, continue to react for 1-4h to make molybdenum disulfide nanosheets, add in proportion to molybdenum disulfide nanosheets Metered amino modifier, mechanically stirred or ultrasonically oscillated for 1-4 hours, the reaction product was washed three times with absolute ethanol, separated by centrifugation, and dried in a vacuum oven for 24 hours to obtain magnetically functionalized molybdenum disulfide nanosheets;

[0035] Among the...

Embodiment 1

[0045] (1) Preparation of magnetically functionalized molybdenum disulfide nanosheets

[0046] Add 5.0g of commercial molybdenum disulfide powder into 500mL of deionized water, place in a low-power ultrasonic tank, and ultrasonically oscillate for 0.5-12h; add 8.0g of FeCl 3 ·6H 2 O and 2.94 g FeCl 2 4H 2 O, stir it evenly with nitrogen bubbling method, then heat up to 60°C, gradually add 2.5M sodium hydroxide solution dropwise to make the pH value of the reaction system 10-14, react for 0.5-2h and heat to 90°C, continue the reaction for 1- 4h; add 0.25g γ-aminopropyltriethoxysilane, mechanically stir or ultrasonically vibrate for 4-12h, the reaction solution is ultrasonically dispersed with phosphate buffer solution and then centrifuged at 4000r / min, and the reaction product is washed with absolute ethanol Washing with alcohol three times, drying in a vacuum oven for 24 hours to obtain magnetically functionalized molybdenum disulfide nanosheets;

[0047] (2) Preparation o...

Embodiment 2

[0052] (1) Preparation of magnetically functionalized molybdenum disulfide nanosheets

[0053] Add 5.0g of commercial molybdenum disulfide powder into 500mL of deionized water, place in a low-power ultrasonic tank, and ultrasonically oscillate for 0.5-12h; add 8.0g of FeCl 3 ·6H 2 O and 4.85 g CoCl 2 ·6H 2 O, stir it evenly with nitrogen bubbling method, then heat up to 60°C, gradually add 2.5M sodium hydroxide solution dropwise to make the pH value of the reaction system 10-14, react for 0.5-2h and heat to 90°C, continue the reaction for 1- 4h; add 0.25g γ-aminopropyltriethoxysilane, mechanically stir or ultrasonically vibrate for 4-12h, the reaction solution is ultrasonically dispersed with phosphate buffer solution and then centrifuged at 4000r / min, and the reaction product is washed with absolute ethanol Washed with alcohol three times, and dried in a vacuum oven for 24 hours to obtain magnetically functionalized molybdenum disulfide nanosheets.

[0054] (2) Preparatio...

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Abstract

The invention discloses a folic acid targeted magnetic functionalized molybdenum disulfide medicine carrier and a preparation method thereof. The preparation method comprises the following steps: firstly, by using a chemical co-precipitation method, modifying surfaces of molybdenum disulfide nano-sheets with MFe2O4 (M=Fe, Co and Ni) magnetic nano-particles, further performing amino-functionalized modification on the magnetic molybdenum disulfide nano-sheets, performing targeting modification by using folic acid as a targeting biological molecule through reaction that amido bonds are formed from carboxyl and amino, and finally loading an anti-tumor medicine, thereby obtaining the folic acid targeted magnetic functionalized molybdenum disulfide medicine carrier. The folic acid targeted magnetic functionalized molybdenum disulfide medicine carrier has the advantages of being controllable in operation process, gentle in reaction condition and easy in large-scale production; by adopting the preparation method, the medicine carrying capacity, blood half life and average retention time of the anti-tumor medicine are remarkably increased; and meanwhile, a medicine transmission system based on the nano composite material can reach and be enriched at focal parts in a targeted manner, and the medicine can be slowly released and is intelligently controllable, thereby achieving the purposes that the toxic or side effects of the anti-tumor medicines are alleviated, the medicine concentration at diseased regions is increased and the treatment effect on tumors is improved.

Description

technical field [0001] The invention relates to the field of novel drug carriers, in particular to a folic acid targeting magnetically functionalized molybdenum disulfide drug carrier and a preparation method thereof. Background technique [0002] Cancer is increasingly becoming the most serious major disease that endangers human health. According to the report of the World Health Organization (WHO), in 2012, the number of new cancer cases and deaths in the world reached 14 million and 8.2 million respectively, among which the number of newly diagnosed cancer cases in China was 3.07 million, accounting for 21.8% of the global total, and the number of cancer deaths was about 2.2 million. million, accounting for 26.9% of global cancer deaths. Basic research and effective treatment are considered to be the key link and effective means to cure cancer. Compared with traditional radiotherapy, chemotherapy and surgery, targeted drug carriers are highly selective to tumor cells an...

Claims

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Application Information

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IPC IPC(8): A61K47/54A61K47/52A61K49/18A61K31/704A61P35/00
CPCA61K31/704A61K31/282A61K31/337A61K31/513A61K31/675A61K31/7024A61K31/7068A61K33/24A61K49/1821A61K49/183
Inventor 王光硕马莹莹刘文波周培涵
Owner HEBEI UNIV OF ENG
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