Porous hydroxyapatite bone repairing material and preparation method thereof

A hydroxyapatite bone and repair material technology, applied in medical science, prosthesis, etc., can solve the problems of collagen being easily digested by protease and poor material toughness, achieve good water solubility and biocompatibility, and improve toughness performance , the effect of enhancing toughness

Active Publication Date: 2017-06-06
福建吉特瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cross-linked collagen scaffold material has good mechanical strength properties, mainly because of good compressive strength, but the toughness of the material is poor, and collagen is easily digested by protease when implanted in the body.

Method used

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  • Porous hydroxyapatite bone repairing material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A porous hydroxyapatite bone repair material, the composition of the bone repair material includes by weight: 10 parts of hydroxyapatite, 2.5 parts of collagen, 16 parts of chitosan, 0.5 parts of polyvinyl alcohol, polyethylene glycol 2 parts of diol, the collagen is type I active collagen.

[0027] A method for preparing a porous hydroxyapatite bone repair material, comprising the following specific steps:

[0028] (1) Dissolve chitosan and collagen in an acetic acid solution with a volume fraction of 1%, and dissolve polyvinyl alcohol and polyethylene glycol in a malonic acid solution with a volume fraction of 0.3%;

[0029] (2) Slowly add the acetic acid solution of chitosan and the acetic acid solution of collagen to the malonic acid solution of polyvinyl alcohol / polyethylene glycol, stir for 2 hours, and mix them well to obtain collagen / chitosan / polyvinyl alcohol / polyethylene glycol solution;

[0030] (3) Under vigorous stirring, add 2 mol / L calcium nitrate solu...

Embodiment 2

[0037] A porous hydroxyapatite bone repair material, the composition of the bone repair material includes by weight: 15 parts of hydroxyapatite, 4 parts of collagen, 18 parts of chitosan, 1 part of polyvinyl alcohol, polyethylene 4 parts of diol, the collagen is type I active collagen.

[0038] A method for preparing a porous hydroxyapatite bone repair material, comprising the following specific steps:

[0039] (1) Dissolve chitosan and collagen in an acetic acid solution with a volume fraction of 1.5%, and dissolve polyvinyl alcohol and polyethylene glycol in a malonic acid solution with a volume fraction of 0.4%;

[0040] (2) Slowly add the acetic acid solution of chitosan and the acetic acid solution of collagen to the malonic acid solution of polyvinyl alcohol / polyethylene glycol, stir for 2.5 hours, and mix them well to obtain collagen / chitosan Sugar / polyvinyl alcohol / polyethylene glycol solution;

[0041] (3) Under vigorous stirring, add 2.5 mol / L calcium nitrate solutio...

Embodiment 3

[0048] A porous hydroxyapatite bone repair material, the composition of the bone repair material includes by weight: 20 parts of hydroxyapatite, 5 parts of collagen, 20 parts of chitosan, 1.5 parts of polyvinyl alcohol, polyethylene 6 parts of diol, the collagen is type I active collagen.

[0049] A method for preparing a porous hydroxyapatite bone repair material, comprising the following specific steps:

[0050] (1) Dissolve chitosan and collagen in an acetic acid solution with a volume fraction of 2%, and dissolve polyvinyl alcohol and polyethylene glycol in a malonic acid solution with a volume fraction of 0.5%;

[0051] (2) Slowly add the acetic acid solution of chitosan and the acetic acid solution of collagen to the malonic acid solution of polyvinyl alcohol / polyethylene glycol, stir for 3 hours, and mix them well to obtain collagen / chitosan / polyvinyl alcohol / polyethylene glycol solution;

[0052] (3) Under vigorous stirring, add 3 mol / L calcium nitrate solution and ...

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Abstract

The invention provides a porous hydroxyapatite bone repairing material and a preparation method thereof. The bone repairing material comprises the following components in parts by weight: 10-20 parts of hydroxyapatite, 2.5-5 parts of collagen, 16-20 parts of chitosan, 0.5-1.5 parts of polyvinyl alcohol and 2-3 parts of polyethylene glycol, wherein the collagen is I-type active collagen. Through addition of PVA and PEG according to the weight ratio of 1: 4 for modifying a system consisting of hydroxyapatite, collagen and chitosan, the porous hydroxyapatite composite bone repairing material with excellent mechanical strength and mechanical properties is obtained.

Description

technical field [0001] The invention belongs to the field of bone tissue repair material manufacturing, and in particular relates to a porous hydroxyapatite bone repair material and a preparation method thereof. Background technique [0002] Biomedical composite materials are biomedical materials composed of two or more different materials, which are mainly used for the repair and replacement of human tissue and the construction of artificial organs. The mechanical properties and biological activity of a single polymer material are often difficult to meet the requirements of bone repair materials. Biomedical composite materials made of materials with different properties not only have the properties of component materials, but also can obtain new properties that single-component materials do not have. With a broad approach, biomedical composite materials have become one of the most active fields in the research and development of biomedical materials. [0003] For an ideal...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50A61L27/56
Inventor 张其清张瑗陈灵艳王临钊邢永振
Owner 福建吉特瑞生物科技有限公司
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