Carboxymethyl chitosan operation anti-adhesion liquid and preparation method thereof

A carboxymethyl chitosan and anti-adhesion technology, which is applied in the field of surgical anti-adhesion liquid and its preparation, can solve the problems affecting the product quality of carboxymethyl chitosan surgical anti-adhesion liquid, the increase of the cost of the anti-adhesion liquid, and the decrease in molecular weight, etc. problems, to achieve the effect of good application prospects, low cost, and increased water absorption

Inactive Publication Date: 2017-04-05
济南康桥医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned traditional technique uses chitosan as a raw material. In terms of price and source, it is not as advantageous as chitin, which can further lead to an increase in the cost of carboxymethyl chitosan surgical anti-adhesion fluid. When the reaction temperature is high, it is easy to cause chain scission, resulting in a sharp drop in molecular weight, resulting in low product viscosity and affecting the quality of carboxymethyl chitosan surgical anti-adhesion liquid

Method used

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  • Carboxymethyl chitosan operation anti-adhesion liquid and preparation method thereof
  • Carboxymethyl chitosan operation anti-adhesion liquid and preparation method thereof
  • Carboxymethyl chitosan operation anti-adhesion liquid and preparation method thereof

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Embodiment 1

[0031] A carboxymethyl chitosan surgical anti-adhesion liquid, comprising 1 weight part of carboxymethyl chitosan with a molecular weight of 200,000 to 300,000 Daltons, 0.5 weight part of carboxymethyl starch and 50 weight parts of water for injection, the liquid viscosity is 3245mPa·s, the specific preparation method is as follows:

[0032] (1) Purification of chitin and removal of impurities

[0033] Purification: Weigh 1.5 kg of chitin with a molecular weight of 250,000 to 350,000 Daltons, add a large amount of deionized water to clean, stir vigorously, filter after standing, and wash with deionized water for 5 times until the upper layer of water is clear. Add 50 parts of 95% ethanol, stir and dehydrate twice, filter and dry at 60° C. for 10 hours in a blast drying oven for use.

[0034] Add 1.2 kg of the above-mentioned purified chitin to 10 kg of aqueous sodium hydroxide solution with a concentration of 38 mol / L, stir at 60°C for 90 min, cool to room temperature, wash w...

Embodiment 2

[0042] A carboxymethyl chitosan surgical anti-adhesion liquid, comprising 1 weight part of carboxymethyl chitosan with a molecular weight of 200,000 to 300,000, 0.8 weight part of carboxymethyl starch and 80 weight parts of water for injection, the liquid viscosity is 689mPa· s, the specific preparation method is as follows:

[0043] (1) Purification of chitin and removal of impurities

[0044] Purification: Weigh 1.5kg of chitin with a molecular weight of 250,000 to 350,000, add a large amount of deionized water to wash, stir vigorously, filter after standing, wash with deionized water 4 times until the upper layer of water is clear, add 50kg after filtering, 95% ethanol, stirred and dehydrated twice, filtered and dried in a blast drying oven at 60°C for 10 hours, ready to use.

[0045] Add 1.2 kg of the above-mentioned purified chitin to 10 kg of aqueous sodium hydroxide solution with a concentration of 20 mol / L, stir at 80°C for 60 min, cool to room temperature, wash with ...

Embodiment 3

[0053] A carboxymethyl chitosan surgical anti-adhesion liquid, comprising 1 weight part of carboxymethyl chitosan with a molecular weight of 200,000 to 300,000, 1 weight part of carboxymethyl starch and 60 weight parts of water for injection, the liquid viscosity is 1580mPa· s, the specific preparation method is as follows:

[0054] (1) Purification of chitin and removal of impurities

[0055] Purification: Weigh 1.5 kg of chitin with a molecular weight of 250,000 to 350,000, add a large amount of deionized water to wash, stir vigorously, filter after standing, and wash with deionized water for 3 times until the upper layer of water is clear, add 50 kg after filtering, 95% ethanol, stirred and dehydrated twice, filtered and dried in a blast drying oven at 60°C for 10 hours, ready to use.

[0056] Add 1.2 kg of the above purified chitin to 10 kg of aqueous sodium hydroxide solution with a concentration of 30 mol / L, stir at 90°C for 100 min, cool to room temperature, wash with ...

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Abstract

The invention relates to the technical field of surgical operation anti-adhesion liquid and preparation method, in particular to a carboxymethyl chitosan operation anti-adhesion liquid and a preparation method. The operation anti-adhesion liquid is prepared from 1 part by weight of refined carboxymethyl chitosan Dalton with a molecular weight of 200-3000 dalton, 0.5-1 part by weight of carboxymethyl starch and 50-80 parts by weight of water for injection. The preparation method includes the steps of: (1) chitin purification and proteinogen impurity removal; (2) deacetylation and carboxymethylation of chitin; (3) purification of carboxymethyl chitosan; and (4) preparation of the operation anti-adhesion liquid. The carboxymethyl chitosan operation anti-adhesion liquid provided by the invention has the characteristics of high concentration, good water solubility and biocompatibility, and low cost, etc., by means of the high substitution degree of carboxymethyl chitosan, the hydrophilicity, solubility, water absorption and other properties of the anti-adhesion liquid are significantly improved, and the anti-adhesion effect is good.

Description

technical field [0001] The invention relates to the technical field of surgical anti-adhesion liquid and its preparation method, in particular to a carboxymethyl chitosan surgical anti-adhesion liquid and its preparation method. Background technique [0002] Chitin is the second largest biological polysaccharide after cellulose on the earth. It is widely found in the hard parts and In the cicada pupal shell, the industrial production of chitosan mainly comes from shrimp shells and crab shells. Chitin is difficult to dissolve in water, alkenoic acid, dilute alkali and general organic solvents, but it can become soluble chitin (chitosan) after being treated with concentrated alkali to remove more than 55% of the N-acetyl group. The molecular structure unit is : [0003] [0004] By carboxymethylating chitosan, carboxymethyl chitosan with more superior properties will be obtained. Chitosan C3, the hydroxyl group at the C6 position and the primary amino group at the C2 pos...

Claims

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Application Information

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IPC IPC(8): A61K31/716A61P41/00C08B37/08
Inventor 王瑛孙斌王岩
Owner 济南康桥医药科技有限公司
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