Carboxymethyl chitosan operation anti-adhesion liquid and preparation method thereof
A carboxymethyl chitosan and anti-adhesion technology, which is applied in the field of surgical anti-adhesion liquid and its preparation, can solve the problems affecting the product quality of carboxymethyl chitosan surgical anti-adhesion liquid, the increase of the cost of the anti-adhesion liquid, and the decrease in molecular weight, etc. problems, to achieve the effect of good application prospects, low cost, and increased water absorption
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Embodiment 1
[0031] A carboxymethyl chitosan surgical anti-adhesion liquid, comprising 1 weight part of carboxymethyl chitosan with a molecular weight of 200,000 to 300,000 Daltons, 0.5 weight part of carboxymethyl starch and 50 weight parts of water for injection, the liquid viscosity is 3245mPa·s, the specific preparation method is as follows:
[0032] (1) Purification of chitin and removal of impurities
[0033] Purification: Weigh 1.5 kg of chitin with a molecular weight of 250,000 to 350,000 Daltons, add a large amount of deionized water to clean, stir vigorously, filter after standing, and wash with deionized water for 5 times until the upper layer of water is clear. Add 50 parts of 95% ethanol, stir and dehydrate twice, filter and dry at 60° C. for 10 hours in a blast drying oven for use.
[0034] Add 1.2 kg of the above-mentioned purified chitin to 10 kg of aqueous sodium hydroxide solution with a concentration of 38 mol / L, stir at 60°C for 90 min, cool to room temperature, wash w...
Embodiment 2
[0042] A carboxymethyl chitosan surgical anti-adhesion liquid, comprising 1 weight part of carboxymethyl chitosan with a molecular weight of 200,000 to 300,000, 0.8 weight part of carboxymethyl starch and 80 weight parts of water for injection, the liquid viscosity is 689mPa· s, the specific preparation method is as follows:
[0043] (1) Purification of chitin and removal of impurities
[0044] Purification: Weigh 1.5kg of chitin with a molecular weight of 250,000 to 350,000, add a large amount of deionized water to wash, stir vigorously, filter after standing, wash with deionized water 4 times until the upper layer of water is clear, add 50kg after filtering, 95% ethanol, stirred and dehydrated twice, filtered and dried in a blast drying oven at 60°C for 10 hours, ready to use.
[0045] Add 1.2 kg of the above-mentioned purified chitin to 10 kg of aqueous sodium hydroxide solution with a concentration of 20 mol / L, stir at 80°C for 60 min, cool to room temperature, wash with ...
Embodiment 3
[0053] A carboxymethyl chitosan surgical anti-adhesion liquid, comprising 1 weight part of carboxymethyl chitosan with a molecular weight of 200,000 to 300,000, 1 weight part of carboxymethyl starch and 60 weight parts of water for injection, the liquid viscosity is 1580mPa· s, the specific preparation method is as follows:
[0054] (1) Purification of chitin and removal of impurities
[0055] Purification: Weigh 1.5 kg of chitin with a molecular weight of 250,000 to 350,000, add a large amount of deionized water to wash, stir vigorously, filter after standing, and wash with deionized water for 3 times until the upper layer of water is clear, add 50 kg after filtering, 95% ethanol, stirred and dehydrated twice, filtered and dried in a blast drying oven at 60°C for 10 hours, ready to use.
[0056] Add 1.2 kg of the above purified chitin to 10 kg of aqueous sodium hydroxide solution with a concentration of 30 mol / L, stir at 90°C for 100 min, cool to room temperature, wash with ...
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