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Multifunctional anti-tumor polymer drug as well as preparation method and application thereof

A polymer and conjugated polymer technology, applied in the field of polymer drug diagnosis and treatment preparations, can solve the problems of low carbon monoxide donor loading efficiency, no I and II photodynamic therapy effects, etc., and achieve good water solubility and biocompatibility The effect of the properties, the preparation method is simple

Pending Publication Date: 2022-08-09
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Purpose of the invention: The purpose of the present invention is to provide a multifunctional polymer anti-tumor drug and its preparation method and application, so as to solve the problem that the polymer materials for fluorescence imaging in the second near-infrared region in the prior art do not have type I and II photodynamic therapy effects, The problem of low carbon monoxide donor loading efficiency

Method used

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  • Multifunctional anti-tumor polymer drug as well as preparation method and application thereof
  • Multifunctional anti-tumor polymer drug as well as preparation method and application thereof
  • Multifunctional anti-tumor polymer drug as well as preparation method and application thereof

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Embodiment 1

[0058] Dissolve 20 mg / ml of water-soluble brush-type structure conjugated polymer with polyethylene glycol molecular weight of 5000 and CORM-401 content of 1% in dimethyl sulfoxide, and mix 5.0 ml of water-soluble brush-type structure under stirring The dimethyl sulfoxide solution of the structurally conjugated polymer was added to 5.0 ml of water, and the concentration of the aqueous solution was adjusted to 5 mg / ml after dialysis for one day to obtain a polymer drug.

[0059] figure 1 The transmission electron microscope photo of the polymer drug obtained in this example, by figure 1 It can be seen that under this ratio, polymer drug particles with a particle size ranging from 150 to 170 nanometers are obtained.

[0060] figure 2 The hydrodynamic particle size measured by dynamic light scattering of the polymer drug obtained in this example is consistent with the result of transmission electron microscope.

[0061] image 3 The actual picture of the carbon monoxide bubb...

Embodiment 2

[0067] Dissolve 10 mg / ml of water-soluble brush-type structure conjugated polymer with polyethylene glycol molecular weight of 2000 and CORM-401 content of 5% in dimethyl sulfoxide. The dimethyl sulfoxide of the structurally conjugated polymer was added to 10.0 ml, and the concentration of the aqueous solution was adjusted to 2 mg / ml after dialysis for one day to obtain a polymer drug.

[0068] Figure 7 and Figure 8 The curves of photodynamic I and II generated by the polymer drug obtained in this example under the irradiation of an 808 nm light source are respectively. It can be seen from the figure that the polymer drug prepared in this example can generate type I and type II photodynamic forces under the irradiation of near-infrared light of 808 nm.

[0069] Figure 9 and Figure 10 The curves of photodynamic I and II generated by the polymer drug obtained in this example under the irradiation of a 740 nm light source are respectively. It can be seen from the figure ...

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Abstract

The invention discloses a multifunctional anti-tumor polymer drug as well as a preparation method and application thereof. The polymer drug is formed by assembling water-soluble brush-shaped structure conjugated polymers in an aqueous solution. According to the water-soluble conjugated polymer with the brush-like structure, polybenzothiadiazole-fluorene serves as a conjugated main chain, amide-amine dendritic molecules serve as side chains, and the surface of the polymer is modified with a carbon monoxide donor CORM-401 and polyethylene glycol. The polymer drug provided by the invention can generate type I and type II photodynamics under irradiation of near-infrared light so as to realize photodynamic therapy of tumors. Under the irradiation of near-infrared light, the polymer drug can release carbon monoxide to realize the gas treatment of tumors. In addition, the polymer drug can generate near-infrared two-region fluorescence under excitation of near-infrared light, so that optical imaging of tumors is realized.

Description

technical field [0001] The invention belongs to the technical field of polymer drug diagnosis and treatment preparations, and in particular relates to a multifunctional anti-tumor polymer drug, a preparation method and application thereof, and aims to improve the water solubility, photodynamic therapy effect and near-infrared second region fluorescence of the tumor polymer drug. At the same time, it has the effect of light-excited gas in the treatment of tumors. Background technique [0002] Tumor is the most important disease affecting human health. At present, the main treatment methods for tumors are chemical drugs and radiation therapy. However, these two traditional treatment methods have great side effects on the human body. In the past two decades, scientists have developed a variety of new anti-tumor technologies, such as photodynamic therapy, photothermal therapy, and gas therapy based on carbon monoxide or nitric oxide. focus. Among them, the combination therapy ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/555A61K33/00A61K47/60A61K47/59A61K47/69A61P35/00A61K49/00
CPCA61K41/0057A61K31/555A61K33/00A61K47/60A61K47/595A61K47/59A61K47/6921A61P35/00A61K49/0089A61K49/0054A61K2300/00Y02A50/30
Inventor 孙鹏飞杜鑫龙何坤蒋欣悦范曲立
Owner NANJING UNIV OF POSTS & TELECOMM
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