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Composition for treating HPV infection and application of composition

A composition and drug technology, applied in the field of protein compositions for treating HPV infection, can solve problems such as side effects and expensive drugs, and achieve the effects of promoting inflammation elimination, prolonging action time, and repairing wound surfaces

Inactive Publication Date: 2017-06-06
BENGT I SAMUELSSON INST OF LIFE SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Injection of immune enhancers such as interferon and interleukin will play a certain role, but its curative effect is still controversial in academia, and most people will have certain side effects, and related drugs are expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: The preparation method of mussel soft tissue extract.

[0046] Take mussels and remove their shells, collect 300 g of soft tissue, divide them into three parts, add 100 ml of the acidic solution in Table 1 below with a content of 0.3%, homogenate for 10 minutes, and centrifuge to obtain the supernatant, which is the mussel soft tissue extract.

[0047] The protein content and pH value in the supernatant were determined, and the protein content was determined by the Coomassie brilliant blue method.

[0048] Table 1

[0049] example acid solution protein content pH value 1 citric acid 2.6mg / ml 4.5 2 Acetic acid 3.5mg / ml 3.2 3 perchloric acid 3.0mg / ml 1.0

Embodiment 2

[0050] Embodiment 2: A kind of protein composition for treating HPV infection

[0051] The composition comprising the mussel soft tissue extract and trypsin consists of the following components: 15 mg dry powder of the mussel soft tissue extract and 20 mg dry powder of trypsin, which are respectively added into purified water and fully dissolved to obtain an oral solution.

[0052] A total of 30 female patients who were infected with high-risk HPV types (including types 16, 18, 31, 33, 35, 39, 45, 51, etc.) but had no clinical symptoms were collected and randomly divided into experimental group and control group. Group. The test group took the composition prepared in Example 2, first took mussel soft tissue extract oral solution 10ml, and then took trypsin oral solution 10ml after an interval of 30 minutes, once a day. Sexual life and bathing were prohibited during the medication period, and menstrual periods were suspended. , used continuously for 2 weeks. The control group...

Embodiment 3

[0054] Embodiment 3: A kind of protein composition for treating HPV infection

[0055] The composition comprising mussel soft tissue extract and trypsin is composed of the following components: mussel soft tissue extract dry powder 10mg, trypsin dry powder 15mg, mussel soft tissue extract and trypsin are sieved, compressible starch, microcrystalline Cellulose and sodium carboxymethyl cellulose are mixed, granulated with 5% hypromellose aqueous solution, dried at 60°C, and the prescribed amount of low-substituted hydroxypropyl cellulose, micropowder silica gel, trypsin, mussel soft tissue The extract is mixed evenly and mixed with granules, and then packed into granules.

[0056] Collect 30 patients with cervical HPV infection, aged between 20-50, the course of disease is 3-21 months. The diagnostic criteria for cervical HPV infection are as follows: the exfoliated cells of the cervix are collected, and the RLU / Co≥1.0 of the test sample is diagnosed as positive for cervical HP...

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PUM

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Abstract

The invention relates to a protein composition for treating HPV infection and application of the composition. The protein composition is prepared from a mussel soft tissue extract and trypsin, optionally can comprise other carriers. The protein composition provided by the invention can be used for treating HPV infection and HPV infection-related diseases, such as a cervical cancer and genital wart, and a solving scheme which is good in curative effect, short in acting time, free of dependence, free of toxic or side effect and low in recurrence rate is provided for HPV infection patients.

Description

technical field [0001] The present invention relates to the technical field of medical supplies or daily necessities, and more specifically relates to a protein composition for treating HPV infection and its application. Background technique [0002] Human papillomavirus (HPV) belongs to the Papillomavirus genus of the family Papillomaviridae, and is a spherical non-enveloped small double-stranded circular DNA virus. More than 200 types have been found, including epithelial types (eg, types 1, 5, 8, 14, 20, 21, 25, and 47) and mucosal types (eg, types 6, 11, 16, 18, 31, 33, 35, 39, 41, 45, 51, 52, 56, 58, 59, 68, 70), HPV can be divided into high-risk and low-risk types according to whether it causes cancer. The pathogenic mechanism of HPV is that HPV has a high affinity for skin and mucosal epithelial cells. After infecting host skin or mucosal epithelial cells, it can self-replicate in the nucleus or integrate into the host cell DNA, and replicate synchronously with the h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61P31/20A61P17/02A61K35/618
CPCA61K9/0031A61K35/618A61K38/4826C12Y304/21004A61K2300/00Y02A50/30
Inventor 高敏
Owner BENGT I SAMUELSSON INST OF LIFE SCI CO LTD
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