Traditional Chinese medicine composition for treating posterior circulation stroke and preparation method of traditional Chinese medicine composition

A technology for ischemic stroke and composition, applied in the field of traditional Chinese medicine composition for the treatment of posterior circulation ischemic stroke and its preparation, which can solve the problems of heart failure, blood reflux, increased medical risk and the like

Inactive Publication Date: 2017-05-31
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that instead of achieving blood reperfusion, vasodilators can cause the blood in the lesion to backflow to healthy brain tissue, so the use of such drugs is no longer recommended
[0006] 2. Drugs that improve microcirculation and expand blood volume (such as low-molecular-weight dextran): At present, this type of drug is widely used, but it is easy to cause heart failure, and it is not easy for patients with heart disease to use it.
[0007] 3. Thrombolytic drugs (such as recombinant human tissue plasminogen activator, urokinase): These drugs often require large doses as thrombolytic drugs, which will cause bleeding risks
Cerebral angiography is required before and after administration, which not only increases medical risks, but also delays the timing of treatment
[0008] 4. Anticoagulant drugs (such as heparin, hirudin): these drugs can prevent blood coagulation, but also have the risk of bleeding
[0012] However, the curative effect of the above-mentioned traditional Chinese medicines and chemical drugs on posterior circulation ischemic stroke is still unsatisfactory.
There is also no research report on wheat bran and its extracts or Drunken Horse Grass and its extracts in the treatment of posterior circulation ischemic stroke

Method used

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  • Traditional Chinese medicine composition for treating posterior circulation stroke and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating posterior circulation stroke and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating posterior circulation stroke and preparation method of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Oral solid preparation of traditional Chinese medicine for treating postcirculatory ischemic stroke and its preparation

[0045] The prescription of traditional Chinese medicine oral solid preparation for the treatment of postcirculatory ischemic stroke is shown in the following table:

[0046]

[0047] The preparation method is as follows:

[0048] 1) Take the prescribed amount of Drunken Horse Grass and cut it into small pieces with a length of 1-4cm, fry at 70°C for 7 minutes, add rice vinegar while stirring, the ratio of solid to liquid is 1:2, then dry it to get drunk with vinegar horse grass;

[0049] 2) Take the vinegar-roasted drunk horse grass obtained in step 1), mix it with the prescribed amount of astragalus, rehmannia root, angelica, chuanxiong, cohosh, and wheat bran, and grind it through a 100-mesh sieve for later use;

[0050] 3) Take the prescribed amount of leech, mash it, grind it into a fine powder, and pass it through an 80-mesh sieve...

Embodiment 2

[0059] Example 2 Traditional Chinese Medicine Oral Liquid Preparation for Treating Postcirculatory Ischemic Stroke and Its Preparation

[0060] The prescription of oral liquid preparation of traditional Chinese medicine for the treatment of postcirculatory ischemic stroke is shown in the following table:

[0061]

[0062] The preparation method is as follows:

[0063] 1) Take the prescribed amount of Drunken Horse Grass and cut it into small pieces with a length of 1-4cm, fry at 60°C for 8 minutes, stir while frying, add rice vinegar, the ratio of solid to liquid of rice vinegar is 1:3, then dry to get drunk with vinegar horse grass;

[0064] 2) Take the vinegar-roasted drunk horse grass obtained in step 1), mix it with the prescribed amount of astragalus, rehmannia root, angelica, chuanxiong, cohosh, and wheat bran, and grind it through a 100-mesh sieve for later use;

[0065] 3) Take the prescribed amount of leech, mash it, grind it into a fine powder, and pass it throu...

Embodiment 3

[0070] Example 3 Traditional Chinese Medicine Intravenous Injection for Treating Postcirculatory Ischemic Stroke and Its Preparation

[0071] The prescription of intravenous injection of traditional Chinese medicine for the treatment of postcirculatory ischemic stroke is shown in the following table:

[0072]

[0073] The preparation method is as follows:

[0074] 1) Take the prescribed amount of Drunken Horse Grass and cut it into small pieces with a length of 1-4cm, stir-fry at 60°C for 8 minutes, add rice vinegar while stirring, the ratio of solid to liquid of rice vinegar is 1:2, and then dry it to get drunk with vinegar horse grass;

[0075] 2) Take the vinegar-roasted drunk horse grass obtained in step 1), mix it with the prescribed amount of astragalus, rehmannia root, angelica, chuanxiong, cohosh, and wheat bran, and grind it through a 100-mesh sieve for later use;

[0076] 3) Take the prescribed amount of leech, mash it, grind it into a fine powder, and pass it t...

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Abstract

The invention belongs to the field of medicines and in particular relates to a traditional Chinese medicine composition for treating posterior circulation stroke and a preparation method of the traditional Chinese medicine composition. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 30 to 70 parts of radix astragali seu hedysari, 5 to 30 parts of radix rehmanniae, 5 to 30 parts of Chinese angelica root, 5 to 30 parts of rhizoma chuanxiong, 5 to 20 parts of rhizoma cimicifugae, 5 to 20 parts of wheat bran, 5 to 20 parts of leech and 0.1 to 0.4 part of herb of achnatherum inebrians. The preparation method adopts an alcohol-extraction and water-deposition method and a preparation is an oral granule preparation. The traditional Chinese medicine composition provided by the invention has unexpected treatment effect on the posterior circulation stroke and has relatively small side effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating posterior circulation ischemic stroke and a preparation method thereof. Background technique [0002] Stroke is a common clinical cerebrovascular disease, the fourth leading cause of death in the world, and the leading cause of disability. The disease is prone to lead to central nervous system diseases such as hemiplegia and epilepsy. In severe cases, the patient loses the ability to work and requires long-term monitoring. There are about 70 million stroke patients in my country, and the age-standardized prevalence rate is about 2.6-7.19 per 100,000 people (Liu M, Wu B, Wang WZ, et al. Stroke in China: epidemiology, prevention, and management strategies[J ]. Lancet Neurol, 2007,6:456-464. ), there are 2 million new patients and 1.65 million deaths every year, one person has a stroke every 12 seconds, ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P9/10A61K35/62
CPCA61K35/62A61K36/232A61K36/236A61K36/48A61K36/481A61K36/71A61K36/804A61K36/899A61K2236/10A61K2236/333A61K2236/51A61K2236/53A61K2300/00
Inventor 周海纯马育轩郭蕊珠王艳丽张晓娟
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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