A kind of method of extracting Acanthopanax

A technology of Acanthopanax senticosus and pulverized materials, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as harm to the body, ineffective treatment of diseases, cardiac arrest, etc., to reduce rashes, improve Medication safety, efficacy against cardiac dilatation and weakness

Active Publication Date: 2020-04-17
HARBIN ZHENBAO PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Since the Acanthopanax injection produced in the market is extracted and refined from the Acanthopanax plant, it itself is a mixture of various components. These components are not only different due to different processing techniques, but also different from the raw materials. The place of origin varies. These ingredients not only contain the active ingredients mentioned above, such as flavonoids, saponins and polysaccharides, but also contain many ingredients that have no effect on treating diseases, and even some ingredients that are harmful to the body. If Patients injected with these Acanthopanax injections are likely to have symptoms such as rash, itching, dizziness, headache, and heart palpitations. In severe cases, it may cause cardiac arrest and even death. Therefore, it is necessary to further study the purification of Acanthopanax. Process, control the impurity content in its injection, to minimize the adverse reactions of patients

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  • A kind of method of extracting Acanthopanax
  • A kind of method of extracting Acanthopanax
  • A kind of method of extracting Acanthopanax

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] In this application, Acanthopanax is produced in Changbai Mountain area.

[0045] Acanthopanax purification process steps are as follows:

[0046] 1) Pulverization: pulverize the roots and stems of Acanthopanax senticosus to make pulverized material. The particle size of the pulverized material is 60 mesh, and 5 kg of the pulverized material is weighed.

[0047] 2) Enzymolysis: use enzyme solution to enzymolyze the above-mentioned pulverized material, the enzymolysis conditions are: temperature: 30°C, enzyme solution concentration: 0.45g / mL, pH value: 4.5, solid-liquid ratio, 1:10 , time 2h, to obtain enzymatic hydrolyzate; the enzyme in the enzyme liquid is cellulase.

[0048] 3) Ultrasonic extraction: Ultrasonic extraction of the aforementioned enzymolysis material to obtain ultrasonic extraction material; the ultrasonic extraction conditions are temperature: 30°C, solid-liquid ratio: 1:10, time: 2h, ultrasonic power: 450W.

[0049] 4) Filtration: filter the ultrasoni...

Embodiment 2

[0060] Acanthopanax purification process steps are as follows:

[0061] 1) Pulverization: pulverize the roots and stems of Acanthopanax senticosus to make pulverized material. The particle size of the pulverized material is 100 mesh, and 15 kg of the pulverized material is weighed.

[0062] 2) Ultrasonic extraction: Ultrasonic extraction of the aforementioned enzymolysis material to obtain ultrasonic extraction material; the ultrasonic extraction conditions are temperature: 40°C, solid-liquid ratio: 1:20, time: 2h, ultrasonic power: 550W.

[0063] 3) Filtration: filter the ultrasonic extraction material, then add 5 times the volume of purified water to the filter material, continue to filter, merge the filtrates, and obtain a mixed filtrate;

[0064] 4) Alcohol precipitation: the mixed filtrate was concentrated by vacuum distillation, and then 5 times the volume of 95% ethanol was added to the concentrated solution, and after stirring, it was allowed to stand at room temperatu...

Embodiment 3

[0072] 1) Pulverization: pulverize the roots and stems of Acanthopanax senticosus to make pulverized material. The particle size of the pulverized material is 80 mesh, and 10 kg of the pulverized material is weighed.

[0073] 3) Ultrasonic extraction: Ultrasonic extraction of the above crushed material to obtain ultrasonic extraction material; the ultrasonic extraction conditions are temperature: 50°C, material-liquid ratio: 1:20, time: 2h, ultrasonic power: 600W.

[0074] 4) Filtration: filter the ultrasonic extraction material, then add 5 times the volume of purified water to the filter material, continue to filter, and merge the filtrates to obtain a mixed filtrate;

[0075] 5) Alcohol precipitation: the mixed filtrate was concentrated by vacuum distillation, and then 5 times the volume of 95% ethanol was added to the concentrated solution, stirred and left at room temperature for 4 hours, the alcohol precipitation filtrate was obtained by filtration, and the ethanol was rec...

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Abstract

The invention relates to a method for extracting Acanthopanax, which comprises the following steps: 1) crushing; 2) enzymatic hydrolysis; 3) ultrasonic extraction; 4) filtering; 5) alcohol precipitation; 6) macroporous resin adsorption; 7) Non-polar resin adsorption; 8) Chromatographic column separation; 9) Sterile ultrafiltration. This process makes the extraction efficiency of Acanthopanax more efficient, and can also significantly reduce the polar and non-polar impurities in the extract of Acanthopanax, and reduce the number of patients who are injected with the extract of Acanthopanax senticosus injection. Symptoms such as skin rash, itching, dizziness, headache and heart palpitations, improve the safety of injection drugs.

Description

technical field [0001] The application belongs to the extraction technology of medicinal plants, in particular to a method for extracting Acanthopanax. Background technique [0002] Acanthopanax is a plant of Araliaceae. [0003] Acanthopanax senticosus (Rupr. et Maxim.) The dry root and rhizome or stem of Acanthopanax senticosus (Rupr. et Maxim.) Harms has the effects of nourishing qi and invigorating the spleen, tonifying the kidney and calming the nerves. Its nature is pungent, slightly bitter, warm. Acanthopanax injection is a sterilized aqueous solution made by extracting Acanthopanax senticosus. It is used to treat transient ischemic attack, cerebral arteriosclerosis, cerebral thrombosis, and cerebral embolism caused by liver and kidney insufficiency. It is also used to treat coronary heart disease, angina pectoris with neurasthenia, and menopausal syndrome. [0004] The main active ingredients in Acanthopanax are flavonoids, saponins and polysaccharides, and the hi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/254
CPCA61K9/0019A61K36/254A61K2236/15A61K2236/19A61K2236/331A61K2236/53A61K2236/55
Inventor 方同华项彦华周广红贾文娟徐秀杰王维龙王博冯慧董丽丽
Owner HARBIN ZHENBAO PHARMA
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