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Method for enhancing disintegration resistance of calcium sulfate bone scaffold by utilization of bioglass

A technology of biological glass and calcium sulfate, which is applied in the field of bone tissue engineering, can solve problems such as insufficient mechanical strength, easy disintegration of calcium sulfate, and fast degradation speed, and achieve the effects of improving mechanical properties, inhibiting degradation speed, and delaying degradation

Inactive Publication Date: 2017-05-24
CENT SOUTH UNIV
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Problems solved by technology

[0006] The invention improves the disintegration resistance of calcium sulfate ceramics by using 45S5 bioglass in the process of preparing calcium sulfate bone scaffold by selective laser sintering, and uses 45S5 bioglass as a binder to overcome the easy disintegration, fast degradation speed and mechanical strength of calcium sulfate Insufficient and other shortcomings

Method used

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Embodiment Construction

[0017] The specific implementation manner of the present invention will be further described below in conjunction with an embodiment, but the content of the present invention is not limited thereto.

[0018] (1) Dispersion of particles: slowly add 100 grams of calcium sulfate powder in 900 grams of absolute alcohol, stir while adding, configure a suspension with a mass fraction of 10%, and stir it evenly with ultrasonic; use absolute alcohol as a dispersant, and The dosage is 2% of the mass of the 45S5 bioglass powder to be dispersed, and the ultrasonic stirring is uniform to obtain a 45S5 bioglass suspension with good dispersion performance;

[0019] (2) Mixing of materials: Calcium sulfate is mixed as 90% suspension and 45S5 biological glass suspension according to volume percentage, put into ball mill bucket after ultrasonic stirring, then mix on ball mill for 24 hours, vacuum dry, sieve, Obtain uniformly mixed raw material powder;

[0020] (3) Selective laser sintering: p...

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Abstract

According to the invention, in the selective laser sintering process for preparation of the calcium sulfate bone scaffold, 45S5 bioglass is used as a binder so as to overcome the disadvantage that calcium sulfate is easy to disintegrate and further enhance mechanical property; by the utilization of 45S5 bioglass for coating crystal grain, degradation velocity of calcium sulfate is inhibited so as to achieve the purpose of delaying degradation; and by the characteristic that 45S5 bioglass is easy to bond natural bones, formation of a bone-like apatite layer on the surface of calcium sulfate is induced so as to promote extracellular responses. The method of the invention comprises the following steps: 1, dispersion of particles; 2, mixing of materials; and 3, selective laser sintering. The method of the invention has characteristics of simple preparation process, convenience in operation, low cost, good product performance and easy control of technical parameters.

Description

technical field [0001] The invention relates to a method of using 45S5 bioglass to improve the anti-disintegration performance of calcium sulfate ceramics and further improve its mechanical and biological properties during the preparation of calcium sulfate bone scaffolds by selective laser sintering, belonging to the field of bone tissue engineering. Background technique [0002] Calcium sulfate is a potential biomaterial with good biocompatibility and degradability. It has been used in biomedical materials for more than 100 years. Previous studies have shown that calcium sulfate has good biocompatibility, osteoconductivity, can be completely degraded in vivo, has no inflammation and foreign body stimulation to surrounding tissues, and has potential osteoinductivity, and its induction mechanism is related to the process of calcium sulfate dissolution. It is related to the decrease of the pH value of the local microenvironment. At present, calcium sulfate has bone conductio...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/50A61L27/58C04B35/515C04B35/63
Inventor 帅词俊彭淑平冯佩
Owner CENT SOUTH UNIV
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