Preparation method of cod-liver oil

A technology of cod liver oil and oil phase, which is applied in the field of medicine, can solve problems such as instability, vitamin C instability, and inability to completely solve degradation problems, and achieve the effects of low processing cost, friendly eating environment, and mature preparation process route

Inactive Publication Date: 2017-05-24
尤世元
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main components of three-dimensional cod liver oil emulsion are vitamins A, D, and C. Vitamins A and D are essential substances for human growth and development, especially for the development of fetuses and infants, the integrity of epithelial tissues, vision, blood calcium and phosphorus, and bones. It plays an important role in the growth and development of teeth and teeth. Vitamin C participates in the formation of antibodies, collagen and tissue repair in the body, as well as the metabolism of sugar, fat and protein, and maintains the integrity of blood vessels. Various diseases caused by deficiency, such as night blindness, xerophthalmia, corneal softening, rickets, rickets, etc.; traditionally, three-dimensional cod liver oil emulsion is an oil-in-water emulsifier, that is, an o / w emulsion. The main components of the product contain fat-soluble vitamins A, D and water-soluble vitamin C. Vitamin C is dissolved in the water phase of the emulsion. The following two methods are adopted: one is to refer to the production method of vitamin C injection, and the whole production process should be carried out in an anaerobic environment, and supplementary materials such as chelating agent and antioxidant are added, because the three-dimensional cod liver oil emulsion is an oral emulsion, and it is multi-dose packaging, so its processing and preparation process is difficult to achieve the whole process of anaerobic, the use of this strict control process can only alleviate the degradation of vitamin C, and can not completely solve the problem of degradation; the second is to make vitamin C into inclusion complexes, liposomes and other applications in solid preparations and semi-solid preparations, this inclusion compound is not suitable for emulsions

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  • Preparation method of cod-liver oil
  • Preparation method of cod-liver oil

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Embodiment 1

[0015] Embodiment 1: Preparation of a kind of cod liver oil suitable for adults.

[0016] The present embodiment prepares cod liver oil emulsion 1000g, and its component content is: cod liver oil 10g; Vitamin A 0.062g; Vitamin D 0.163mg; Vitamin C 1.54g; Soybean lecithin 5.235g; Purified water 304g.

[0017] The preparation process of the present embodiment is:

[0018] (1) after adding the soybean lecithin of commercially available product into dehydrated alcohol and stirring and dissolving, it is mixed with soybean lecithin solution;

[0019] (2) Put the vitamin C of the commercially available product through a 100 mesh sieve into a conventional boiling drying bed, and then spray the soybean lecithin solution prepared in step (1) into the drying bed in a boiling state, and control the temperature at 45- Dry vitamin C at 55°C to prepare vitamin C soybean phospholipid microcapsules;

[0020] (3) First, stir and dissolve cod liver oil, vitamin A and vitamin D of commercially...

Embodiment 2

[0021] Embodiment 2: Preparation of a three-dimensional cod liver oil emulsion suitable for children.

[0022] The present embodiment makes three-dimensional cod liver oil emulsion 1000g, and its each component content is: cod liver oil 10g; Vitamin A0.03g; Vitamin D0.338mg; Vitamin C1.54g; Soybean lecithin 5g; 304g of purified water.

[0023] The preparation method of this embodiment is:

[0024] (1) adding soybean lecithin to dehydrated alcohol earlier, after stirring and dissolving, be mixed with soybean lecithin solution;

[0025] (2) Pass the vitamin C through a 100-mesh sieve, put it into a boiling drying bed, spray the soybean lecithin solution in a boiling state, and dry it at 45-55°C to prepare vitamin C soybean lecithin microcapsules;

[0026] (3) Dissolve cod liver oil, vitamin A, and vitamin D in soybean oil in sequence, then add vitamin C soybean lecithin microcapsules and purified water in sequence, stir evenly, and carry out anti-cut emulsification for 30 minu...

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Abstract

The invention relates to a preparation method of cod-liver oil. In accordance with composition and formulation, the percentage by mass of an oil phase in an emulsion is 55-90%, wherein the percentages by mass of various ingredients in the oil phase in the emulsion are as follows: 55-85% of soybean oil, 0.5-10% of cod-liver oil, 0.001-0.01% of vitamin A and 0.00001-0.0001% of vitamin D; the percentage by mass of an aqueous phase in the emulsion is 10-45%; the percentage by mass of an emulsifying agent in the emulsion is 0.1-3%, wherein a vitamin C soybean phospholipid micro-capsule in the emulsifying agent consists of the following ingredients: vitamin C and a capsule-forming material, namely soybean phospholipid, at the mass ratio of 1: (2.5-6), and soybean phospholipid and a solvent, namely absolute ethyl alcohol, at the mass ratio of 1: (10-100); and the preparation method comprises three processing steps: preparing a soybean phospholipid solution, preparing the phospholipid micro-capsule and conducting emulsifying. The preparation method is mature in preparation process route, and the finished product (the cod-liver oil) is rich in nutrition, good in taste, low in processing cost, safe and reliable and environment-friendly to eat.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of medicine and relates to a preparation method of cod liver oil. [0003] Background technique: [0004] The main components of three-dimensional cod liver oil emulsion are vitamins A, D, and C. Vitamins A and D are essential substances for human growth and development, especially for the development of fetuses and infants, the integrity of epithelial tissues, vision, blood calcium and phosphorus, and bones. It plays an important role in the growth and development of teeth and teeth. Vitamin C participates in the formation of antibodies, collagen and tissue repair in the body, as well as the metabolism of sugar, fat and protein, and maintains the integrity of blood vessels. Various diseases caused by deficiency, such as night blindness, xerophthalmia, corneal softening, rickets, rickets, etc.; traditionally, three-dimensional cod liver oil emulsion is an oil-in-water emulsifier, that is, an o / w emuls...

Claims

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Application Information

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IPC IPC(8): A61K35/60A61K9/107A61P3/02A61P27/02A61P19/08A61K31/375A61K31/07A61K31/59A61K47/24
CPCA61K35/60A61K9/0053A61K9/107A61K31/07A61K31/375A61K31/59A61K47/24
Inventor 尤世元
Owner 尤世元
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