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Medicine composition of lidocaine and application of medicine composition

A technology of lidocaine and composition, applied in the field of medicine, can solve problems such as troubles and blows of manufacturing enterprises

Inactive Publication Date: 2017-05-24
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In today's era of strict GMP management and extremely high requirements for drug quality control, any quality problems of injections will bring trouble or even a major blow to a manufacturing company.

Method used

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  • Medicine composition of lidocaine and application of medicine composition
  • Medicine composition of lidocaine and application of medicine composition
  • Medicine composition of lidocaine and application of medicine composition

Examples

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preparation example Construction

[0073] In the description of the present invention or the preparation process of each example, especially when the names of the components have been defined in the prescriptions of the examples, for the sake of simplification, the names of each component in the prescription can be simplified or omitted , for example, lidocaine hydrochloride 1 hydrate in the prescription can be referred to as lidocaine hydrochloride hydrate or lidocaine hydrochloride for short, sodium citrate 2 hydrate is referred to as sodium citrate or vice versa, and L- Menthol is referred to as menthol for short, and other components can be or analogously.

[0074] Concentration units used in the description of the present invention have molar concentration (M) or (mol / L) or equivalent concentration (N), or percentage concentration etc., time unit can use second (s), minute (min), hour (h) Etc., volume unit can use liter (l or L), milliliter (ml), microliter (μl), mass unit can use gram (g), milligram (mg) ...

Embodiment 1

[0079] The preparation of embodiment 1 compound lidocaine carbonate pharmaceutical composition injection (specification: 5ml / supports)

[0080] Prescription: Lidocaine hydrochloride monohydrate 34.61g (weight based on lidocaine net content), 2-hydroxypropyl-β-cyclodextrin inclusion compound of menthol 6.5g (based on menthol net content), 20g of aspartic acid, 250.0ml of glycerin, 10g of polyethylene glycol succinate, 0.05g of disodium edetate, an appropriate amount of 5% sodium bicarbonate solution, an appropriate amount of carbon dioxide gas, and water for injection to 5000ml;

[0081] Preparation process: ① Take prescription amounts of aspartic acid, glycerin, vitamin E polyethylene glycol succinate, disodium edetate and menthol hydroxypropyl-β-cyclodextrin inclusion compound, hydrochloric acid Dissolve lidocaine into a stainless steel bucket containing 4000ml of water for injection, stir and mix well; adjust the pH value of the solution to the range of 7.0 to 7.4 with an a...

Embodiment 2

[0083] The preparation of embodiment 2 compound lidocaine carbonate pharmaceutical composition injection preparation (specification: 10ml / supports)

[0084] Prescription: 69.23g of lidocaine hydrochloride monohydrate (based on the net content of lidocaine), 13.0g of 2-hydroxypropyl-β-cyclodextrin inclusion complex of L-menthol (based on the net content of menthol) , urea 20g, citric acid 15g, sodium citrate 15g, glycerin 350.0ml, vitamin E polyethylene glycol succinate 20g, edetate disodium 2 hydrate 1g, saturated sodium bicarbonate solution, carbon dioxide gas , add water for injection to 10L;

[0085] Preparation process: ① Take the prescribed amount of urea, citric acid, sodium citrate, glycerin, vitamin E polyethylene glycol succinate, disodium edetate and menthol hydroxypropyl-β-cyclodextrin respectively Dissolve the compound and lidocaine hydrochloride in a stainless steel bucket filled with 4000ml of water for injection, stir and mix well; adjust the pH value of the s...

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Abstract

The invention provides a lidocaine medicine composition for preparing local anesthetic for preventing or treating surgical pain of human and mammals, and application of the lidocaine medicine composition in preparation and application of a medicine. Therefore, a corresponding product has a quicker and better treating effect, higher safety and higher treating compliance in a clinical process.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to provide a lidocaine-menthol pharmaceutical composition with quick-acting, powerful and mild side effects as a local anesthetic for preventing or treating surgical pain, and its preparation and application. Background technique [0002] Lidocaine is an amide-type medium-effect local anesthetic. After blood absorption, it has obvious excitatory and inhibitory biphasic effects on the central nervous system, and there may be no precursor excitement. When the blood concentration is low, analgesia, drowsiness, pain threshold Increase; as the dose increases, the effect or toxicity increases, and there is an anticonvulsant effect at the subtoxic blood concentration; when the blood concentration exceeds 5μg·ml -1 Seizures may occur. At low doses, this product can promote k in cardiomyocytes + Outflow, reduce the 4-phase slope, slow down the automatic depolarization of diastole, reduce ...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K47/69A61K9/08A61K9/06A61P23/02A61P23/00A61P29/00A61P25/02A61P25/00A61P17/04A61P17/00A61P31/22A61K31/045A61K31/133A61K31/17A61K31/198A61K31/5375
CPCA61K31/167A61K9/0014A61K9/0019A61K9/06A61K9/08A61K31/045A61K31/133A61K31/17A61K31/198A61K31/5375A61K47/44A61K2300/00
Inventor 刘力
Owner 刘力
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