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Nanofiber membrane and preparation method and application thereof

A nanofiber film and fiber technology, which can be used in fiber processing, pharmaceutical formulations, textiles and papermaking, etc., and can solve the problem that the degradation rate is difficult to adjust

Inactive Publication Date: 2017-05-17
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for implantable bulk materials, the degradation rate is difficult to adjust, and there are still challenges in the controllable drug release and distribution.

Method used

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  • Nanofiber membrane and preparation method and application thereof
  • Nanofiber membrane and preparation method and application thereof
  • Nanofiber membrane and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] In this example, the electrospun membrane of the shell part is prepared by the following method, which specifically includes the following steps:

[0074] 1) Dissolve 7.5g of gelatin and 0.75g of genipin in a mixed solvent of 50mL of acetic acid and water (volume ratio 9:1), stir magnetically at room temperature for 12h, and obtain a shell solution with a mass volume fraction of 16.5%

[0075] 2) Electrospinning the solution, using a stainless steel drum as the receiving device, the voltage is 20KV, the receiving distance is 15cm, the spinning liquid feeding rate is 1mL / h, and the spinning is 5h. A drug-loaded film with a thickness of about 250 μm was obtained.

[0076] 3) Soak the obtained fiber membrane in a fume hood at room temperature and dry for 72 hours to ensure that the residual solvent is fully volatilized.

[0077]The spinning film prepared by embodiment 1 is carried out scanning electron microscope observation, the result is as follows Figure 1A As shown, ...

Embodiment 2

[0079] In this embodiment, the electrospun membrane of the core part is prepared by the following method, which specifically includes the following steps:

[0080] 1) Dissolve 3 g of polylactic acid-glycolic acid and 3 g of polycaprolactone in 20 mL of hexafluoroisopropanol, then add 0.0625 g of DOX, and stir magnetically at room temperature for 12 hours to obtain an inner core solution with a mass volume fraction of 30 w / v%.

[0081] 2) The solution was electrospun, with a stainless steel flat table as the receiving device, the voltage was 20KV, the receiving distance was 15cm, the spinning liquid inflow rate was 0.17mL / h, and the spinning was 5h. A drug-loaded film with a thickness of about 250 μm was obtained.

[0082] 3) Soak the obtained fiber membrane in a fume hood at room temperature and dry for 72 hours to ensure that the residual solvent is fully volatilized.

[0083] The spinning membrane prepared by embodiment 2 is carried out scanning electron microscope observat...

Embodiment 3

[0085] In this embodiment, the nanofibrous membrane with core-shell structure is prepared by the following method, which specifically includes the following steps:

[0086] 1) Dissolve 3g of polylactic acid-glycolic acid (weight average molecular weight of 80,000) and 3g of polycaprolactone (weight average molecular weight of 60,000) in 20mL of hexafluoroisopropanol, then add 0.0625g of DOX, and stir magnetically at room temperature After 12 hours, an inner core solution A with a mass volume fraction of 30w / v% was obtained.

[0087] 2) Dissolve 7.5g of gelatin and 0.75g of genipin in a mixed solvent of 50mL of acetic acid and water (volume ratio 9:1), and magnetically stir at room temperature for 12h to obtain a shell solution B with a mass volume fraction of 16.5%;

[0088] 3) The solution was electrospun, and solution A and solution B were placed in two syringes, which were pushed by propellers respectively. The propulsion speeds of solution A and solution B were 0.17mL / h an...

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Abstract

The invention provides a nanofiber membrane and a preparation method and application thereof. The nanofiber membrane is formed by fibers of a core-shell structure and is characterized in that the core is formed by mixed fibers mixed by polylactic acid-hydroxyacetic acid and polycaprolactone, the shell is formed by fibers formed by gelatin crosslinking with genipin, and the core is loaded with chemical therapy medicine. The nanofiber membrane prepared by the coaxial electrospinning technology has an in-situ anti-cancer function and is implantable, good in biocompatibility, free of cytotoxicity to normal cells and good in curative effect on tumor. The preparation method is simple, mild in condition, low in cost and easy to popularize and apply.

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to a nanofiber membrane and its preparation method and application, in particular to a core-shell structure electrospun nanofiber membrane and its preparation method and application. Background technique [0002] Surgical resection, chemotherapy, and radiotherapy are currently the most commonly used treatment strategies for cancer, but there are still major limitations, such as chemotherapy drugs that exceed the tolerance of normal tissues will cause toxicity, the amount of drugs entering solid tumors is low, and radiotherapy is effective in Toxicity in clinical treatment, postoperative patient survival is poor. To overcome these limitations, nanocarrier-based drug delivery systems have attracted increasing attention. Compared with traditional drug injection, these systems have the ability to preferentially carry drugs into tumor tissue. Among many drug carriers, amphiphilic mole...

Claims

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Application Information

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IPC IPC(8): D04H1/4382D01D5/34A61K9/70A61K47/34A61K47/42A61K31/704A61P35/00A61P35/02
CPCD04H1/4382A61K9/0002A61K9/0024A61K9/7007A61K31/704A61K47/34A61K47/42D01D5/34D10B2331/04D10B2331/041D10B2509/00
Inventor 陈春英刘颖郭梦雨
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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