A kind of preparation method of agmatine hydrochloride

Abstract

The invention discloses an agmatine hydrochloride preparation method. The method includes steps: concentrating crystallization mother liquor generated in production of agmatine sulfate to remove a solvent and obtain concentrated liquid; allowing the concentrated liquid to overflow regenerated 717 anion resin to adsorb sulfate ions, collecting lower column liquid until sulfate ions flow out through an outlet, and stopping overflowing; concentrating the collected lower column liquid to obtain crystallization liquid; adopting hydrochloric acid for adjusting pH of the crystallization liquid to 3-6; adding activated carbon, stirring to remove impurities, and filtering to remove carbon; crystallizing to obtain an agmatine hydrochloride product. The agmatine hydrochloride preparation method has advantages that the mother liquid obtained after production of agmatine can be completely used, waste of agmatine is avoided while the agmatine hydrochloride product is obtained, the content of effective components of the hydrochloride product is higher than that of effective components of a sulfate product equal to the hydrochloride product in mass, and accordingly carbon emission is reduced, social benefits are increased, and the production requirement on environmental friendliness is met.

Description

technical field [0001] The invention relates to the technical field of preparation of agmatine hydrochloride or waste liquid treatment. Background technique [0002] Agmatine (agmatine) is a substance with multiple biological functions. It belongs to a class of drugs containing guanidine. Benefits, being able to improve body endurance is of certain benefit and satisfaction to athletes and bodybuilding enthusiasts. At the same time, it can speed up body recovery, increase muscle mass, reduce fat and fat, and improve physical performance. A healthy lifestyle helps, and agmatine also increases nitric oxide levels in two ways, stimulating the release of nitric oxide and inhibiting the synthesis of nitric oxide enzyme. [0003] At present, agmatine is mainly obtained through chemical synthesis in the market. The main raw materials are 1,4-butylene diamine, o-methylisourea sulfate, sulfuric acid, alcohol, etc. The reaction process consumes a lot of energy and the yield is low. ,...

AI Technical Summary

Problems solved by technology

[0003] At present, agmatine is mainly obtained by chemical synthesis in the market. The main raw materials are 1,4-butylene diamine, o-methylisourea sulfate, sulfuric acid, alcohol, etc. The reaction process consumes a lot of energy and the yield is low. , many impurities, great safety hazards, and certain pollution to the environment; at the same time, there are also 1,4-dibromobutane and potassium phthalimide potassium as raw materials, which undergo three-step reactions of substitution, aminolysis, and guanidinylation According to reports on the production of agmatine sulfate, this route has mild reaction conditions, more side reactions, cumbersome operation, unpleasant smell, and more solvents used in the reaction process, which does not meet the clean and efficient production requirements

[0004] Usually, in the later stage of the preparation of agmatine sulfate, there is often a large amount of mother liquor to be treated. There is a large amount of ethanol in the mother liquor that can be recycled and reused, and the content of agmatine is relatively high. Direct discharge causes industrial "three wastes" and does not meet low-carbon requirements. The concept of environmental protection and recycling