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Transparent antibacterial hydrogel dressing as well as preparation method and application thereof

A hydrogel and transparent technology, which is applied in the field of polymer materials and biomaterials, can solve the problems of low water content and poor antibacterial effect, and achieve the effect of improved antibacterial performance, good mechanical strength and flexibility, and short time consumption

Inactive Publication Date: 2017-05-10
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In view of the above defects or improvement needs of the prior art, the present invention provides a transparent antibacterial hydrogel dressing and a preparation method thereof, the purpose of which is to combine bacterial cellulose whiskers and hydrogel monomers Compound I was compounded and soaked in silver nitrate and NaBH 4 In the solution, a transparent antibacterial hydrogel dressing with nano-silver particles attached to the surface is prepared, thereby solving the technical problems of low water content and poor antibacterial effect of the hydrogel dressing in the prior art

Method used

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  • Transparent antibacterial hydrogel dressing as well as preparation method and application thereof
  • Transparent antibacterial hydrogel dressing as well as preparation method and application thereof
  • Transparent antibacterial hydrogel dressing as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0052] The preparation method of described hydrogel dressing, comprises the steps:

[0053] (1) Inoculate bacterial cellulose-producing bacteria in a liquid medium, culture statically at 25°C to 30°C for at least one week to obtain a cellulose film, soak the obtained cellulose film in distilled water for 2 to 4 days, and then place it Into a concentration of 0.1mol / LNaOH solution and boil for 30 minutes, the purpose is to remove the remaining thalline and culture medium, then rinse with deionized water until neutral to obtain bacterial cellulose film;

[0054] (2) The bacterial cellulose film obtained in step (1) is smashed, and the upper layer is taken by centrifugation to obtain the centrifuged cellulose, and the centrifuged cellulose is added to a volume concentration of 40% to 60% sulfuric acid, at 40°C Under the condition of ~60°C, carry out the hydrolysis reaction for 8 hours to 12 hours, after the hydrolysis is completed, perform centrifugation, dialysis, and centrifuga...

Embodiment 1

[0072] (1) The bacterium used in the experiment was Gluconacetobacter, which was inoculated in HS medium and cultured statically in a biochemical incubator at 30°C for one week to obtain a bacterial cellulose film with a thickness of about 10 mm. Boil with 0.1mol / L NaOH solution for half an hour to remove bacterial residues in the culture medium, then soak in deionized water for a week until the pH is neutral, and the purified cellulose membrane can be obtained.

[0073] (2) Mash the bacterial fiber membrane into a slurry, centrifuge (10000 rpm, 10 minutes) to remove the moisture in the homogenate, take the upper layer, and obtain the cellulose after centrifugation; configure 200ml 50% concentrated sulfuric acid, weigh and centrifuge The cellulose, according to adding 200ml 50% concentrated sulfuric acid in every 100g cellulose, water bath 60 ℃ for about 8 hours. After the hydrolysis is completed, first perform centrifugation treatment (10000 rpm, 10 minutes), take the upper l...

Embodiment 2

[0077] Repeat embodiment 1 with described same step, difference is, in step (3), hydroxyethyl methacrylate and bacterial cellulose whisker volume ratio are 1:1.

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Abstract

The invention discloses transparent antibacterial hydrogel dressing and a preparation method thereof. Bacterial cellulose crystal whiskers are compounded with a polymer of gel monomers by adopting an in-situ compositing method; a composite transparent antibacterial gel material is prepared under the action of an initiator, namely ammonium persulfate; the composite transparent antibacterial gel material is used as medical dressing and has high moisture content; a preparation process of the dressing is simple, short in duration and low in cost; the dressing has good elasticity and flexibility and good moisture retention property. By adopting the transparent dressing, lesion and healing conditions of wounds can be clearly observed and pains caused by the fact that the dressing is replaced can be avoided.

Description

technical field [0001] The invention belongs to the fields of biological materials, polymer materials, etc., and in particular relates to a transparent antibacterial hydrogel dressing applied to promote wound healing and prevent wound infection, its preparation method and application. Background technique [0002] Functional medical dressings with high moisture retention and antibacterial properties play an important role during treatment as a temporary skin substitute. When the skin tissue is traumatized, such as burns, abrasions, ulcers, etc., the resistance of the surface cells decreases, and Gram bacteria such as Staphylococcus aureus and Escherichia coli are easy to multiply on the wound, causing further expansion of the wound. Once a wound is infected by bacteria, it is not easy to heal. At present, sterile gauze is the most widely used clinically. It is low in cost and has a certain effect of isolating bacteria. However, when the wound suppurates or body fluids flow ...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08F220/28C08F220/06C08F222/14
CPCA61L26/0004A61L26/0014A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L2300/104A61L2300/404C08F220/06C08F220/28C08F220/281C08L1/02C08L33/14C08L33/02C08F222/102
Inventor 杨光曾迪石志军
Owner HUAZHONG UNIV OF SCI & TECH
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