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Hangover alleviating chewable tablet preparation method

A chewable tablet and filler technology, applied in the field of preparation of chewable tablets, can solve the problems of large side effects, poor taste, unsuitable for patients with poor gastrointestinal function, etc. Effect

Inactive Publication Date: 2017-04-19
南京佳品数控设备有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing anti-alcoholic drugs have relatively large side effects and poor taste, so they are not suitable for patients with poor gastrointestinal function

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Party:

[0018] 30 parts of orange peel, 20 parts of mint, 12 parts of reed root, 8 parts of perilla, 3 parts of mannitol, 3 parts of lemon essence, and 1 part of sucrose.

[0019] Preparation:

[0020] (1) Take the above-mentioned raw materials by weight ratio, dry orange peel, peppermint, reed rhizome and perilla by microwave, pulverize, and obtain the mixture after sieving;

[0021] (2) Put the above mixture into a reaction kettle, add water 5 times the weight of the mixture, heat to 40°C, add mannitol, lemon essence, and sucrose and stir for 30 minutes, continue to heat up to 80°C, and keep warm for 5 minutes to obtain the first mixture ;

[0022] (3) Freeze-dry the first mixed solution at -40°C for 24 hours, perform wet granulation, and compress into tablets to make finished chewable tablets for hangover;

[0023] (4) The hangover-relief chewable finished product obtained in step (3) is sterilized by ultraviolet rays with a wavelength of 250 nm, then packaged, a...

Embodiment 2

[0025] 45 parts of orange peel, 28 parts of mint, 15 parts of reed root, 12 parts of perilla, 8 parts of lactose, 6 parts of strawberry essence, and 4 parts of sucrose.

[0026] Preparation:

[0027] (1) Take the above-mentioned raw materials by weight ratio, dry orange peel, peppermint, reed rhizome and perilla by microwave, pulverize, and obtain the mixture after sieving;

[0028] (2) Put the above mixture into a reaction kettle, add water 8 times the weight of the mixture, heat to 60°C, add lactose, strawberry essence, and sucrose and stir for 40 minutes, continue to heat up to 100°C, and keep warm for 10 minutes to obtain the first mixture;

[0029] (3) Freeze-dry the first mixed solution at -30°C for 24 hours, perform wet granulation, and compress into tablets to make finished chewable tablets for hangover;

[0030] (4) The hangover-relief chewable finished product obtained in step (3) is sterilized by ultraviolet rays with a wavelength of 300 nm, then packaged, and stor...

Embodiment 3

[0032] 38 parts of orange peel, 24 parts of mint, 14 parts of reed root, 10 parts of perilla, 6 parts of sorbitol, 5 parts of clove oil, and 3 parts of sucrose.

[0033] Preparation:

[0034] (1) Take the above-mentioned raw materials by weight ratio, dry orange peel, peppermint, reed rhizome and perilla by microwave, pulverize, and obtain the mixture after sieving;

[0035] (2) Put the above mixture into a reaction kettle, add water 6 times the weight of the mixture, heat to 50°C, add sorbitol, clove oil, and sucrose and stir for 35 minutes, continue to heat up to 90°C, and keep warm for 8 minutes to obtain the first mixed solution ;

[0036] (3) Freeze-dry the first mixed solution at -35°C for 20 hours, perform wet granulation, and compress into tablets to make finished chewable tablets for hangover;

[0037] (4) The hangover-relief chewable finished product obtained in step (3) is sterilized by ultraviolet light with a wavelength of 280nm, then packaged, and stored at roo...

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Abstract

The invention discloses a hangover alleviating chewable tablet preparation method, which comprises: (1) carrying out microwave drying on orange peel, peppermint, rhizoma phragmitis and perilla, crushing, and screening to obtain a mixture; (2) placing the mixture in a reaction kettle, adding water having the amount 5-8 times the weight of the mixture, heating to a temperature of 40-60 DEG C, adding a filler, a flavoring agent and sucrose, stirring for 30-40 min, continuously heating to a temperature of 80-100 DEG C, and carrying out thermal insulation for 5-10 min to obtain a first mixing liquid; (3) carrying out freeze drying on the first mixing liquid for 15-24 h at a temperature of -40 to -30 DEG C, carrying out wet granulation, and tableting to prepare a hangover alleviating chewable tablet finished product; and (4) sterilizing the hangover alleviating chewable tablet finished product obtained in the step (3) through ultraviolet ray with a wavelength of 250-300 nm, packaging, and storing at a room temperature.

Description

technical field [0001] The invention relates to a preparation method of a chewable tablet, in particular to a preparation method of a hangover-relieving chewable tablet. Background technique [0002] Chewable tablets refer to tablets that are chewed or sucked in the mouth to dissolve the tablets and then swallowed. Sweeteners such as sucrose and peppermint oil and flavorings are often added to adjust the taste. Dissolution and absorption in the body. It is convenient to take, it can be swallowed, chewed and sucked or dispersed with water. After the tablet is chewed, the surface area increases, which can promote the dissolution and absorption of the drug in the body. Even in the state of water shortage, the drug can be taken on time. It is especially suitable for the elderly, children, stroke patients, patients with difficulty swallowing and poor gastrointestinal function. Can reduce the burden of drugs on the gastrointestinal tract. [0003] At present, the existing hango...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/20A61K47/46A61K47/44A61P39/02A61P25/00
CPCA61K36/752A61K9/0056A61K9/2013A61K9/2068A61K36/534A61K36/535A61K36/899A61K2236/331A61K2236/51
Inventor 黄玉金
Owner 南京佳品数控设备有限公司
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