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Preparation method of highly dispersed superfine powder particles

A fine powder, high dispersion technology, applied in the field of powder particle preparation, can solve problems such as poor dispersion performance and easy adhesion, and achieve the effects of improving the quality of dry powder inhalants, increasing the inhalable dose, and improving the dispersibility.

Inactive Publication Date: 2017-04-05
SUZHOU OMNI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention provides a highly dispersible microfine powder that is simple in process, low in preparation cost, strong in practicability, low in pollution, has good dispersibility, reduces adhesion and (or) agglomeration of fine powder particles, and is suitable for industrial production. The preparation process of powder particles provides a solution to the problem of poor dispersion performance of fine powder particles in liquid and (or) solid media, and prone to adhesion and (or) agglomeration

Method used

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  • Preparation method of highly dispersed superfine powder particles
  • Preparation method of highly dispersed superfine powder particles
  • Preparation method of highly dispersed superfine powder particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The preparation of embodiment 1 salbutamol sulfate suspension type aerosol (vacuum drying method)

[0068] The active ingredient is the water-soluble active ingredient salbutamol sulfate, the additive is povidone k25, and the propellant is tetrafluoroethane (HFA134a). The preparation process of the aerosol sample is as follows:

[0069] (1) The pretreatment of active ingredient: get above-mentioned active ingredient salbutamol sulfate, through micronization process, obtain fine powder particle;

[0070] (2) Treatment of additives: take the above-mentioned additive povidone k25, add it to dehydrated ethanol, make completely dissolved, and obtain povidone k25 dehydrated alcohol solution;

[0071] (3) Preparation of the sample to be vacuum-dried: adding the water-soluble active ingredient salbutamol sulfate to the povidone k25 absolute ethanol solution, and dispersing evenly with a disperser to obtain a dispersion suspension;

[0072] (4) Sample drying treatment: the disp...

Embodiment 2

[0078] Embodiment 2: the preparation of salbutamol sulfate suspension type aerosol (spray drying method)

[0079] (1) The pretreatment of active ingredient: get above-mentioned active ingredient salbutamol sulfate, through micronization process, obtain fine powder particle;

[0080](2) Treatment of additives: take the above-mentioned additive povidone k25, add it to dehydrated ethanol, make completely dissolved, and obtain povidone k25 dehydrated alcohol solution;

[0081] (3) Preparation of the vacuum-dried sample: the water-soluble active ingredient salbutamol sulfate is added to the povidone k25 absolute ethanol solution, and the disperser is used to disperse evenly to obtain a dispersion suspension;

[0082] (4) Sample spray drying treatment: the dispersion suspension obtained above is subjected to spray drying treatment to obtain dry fine powder particles;

[0083] (5) Sample filling: the active ingredient salbutamol sulfate and the fine powder particles of the above-men...

Embodiment 3

[0085] The preparation of embodiment 3 ribavirin suspension type aerosol (vacuum drying method)

[0086] The drug active ingredient is replaced by water-soluble ribavirin, and the operation is carried out according to Example 1, and the relevant test results are shown in surface 2 .

[0087]

[0088]

[0089] surface 2

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Abstract

The invention provides a preparation method of highly dispersed superfine powder particles. The powder particles consist of an active ingredient and an additive. The preparation method comprises the following steps: (1) acquiring the superfine powder particles containing the active ingredient; (2) processing the additive: adding the additive to an alternative solvent, and completely dissolving the additive so as to obtain an additive solution; (3) preparing a dispersion suspension: adding the superfine powder particles containing the active ingredient to the additive solution, uniformly dispersing the solution by virtue of a dispersing machine and (or) an emulsifying machine, so that the dispersion suspension is obtained; (4) collecting a sample: processing the dispersion suspension by virtue of a drying method so as to obtain dry powder; and (5) obtaining the final superfine powder particles. The preparation method provided by the invention can complete surface treatment merely by virtue of a conventional dispersing technology as well as common vacuum drying, rotary evaporation, spray-drying and freeze-drying technologies, and the preparation method is simple in process.

Description

[0001] The invention relates to a method for preparing powder particles, in particular to a method for preparing highly dispersed fine powder particles. Background technique [0002] Sticking to vessel walls or forming agglomerates often occurs during powder handling or use. Adhesion (adhesion) refers to the attraction between different molecules, such as the adhesion between powder particles and the wall; cohesion (cohesion) refers to the attraction between the same molecules, also known as agglomeration. Adhesion and cohesiveness not only occur in the dry state, but also in the wet state. The main reasons are: in the dry state, it is played by van der Waals force and electrostatic force; in the wet state, it is caused by the particle surface adhesion Moisture forms a liquid bridge. In general, the smaller the particle size of the powder, the greater the surface energy or the more moisture it absorbs, so the adhesion and agglomeration are more likely to occur, thus affecting...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/12A61K9/72A61K47/32A61K47/10A61K47/26A61K47/18A61K47/24A61K47/14
Inventor 王晓飞陈孝果
Owner SUZHOU OMNI PHARMA CO LTD
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