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Silk fibroin suture line with effect of promoting wound healing and preparation method thereof

A technology of silk fibroin and wound healing, applied in medical science, surgery, surgical instruments, etc., can solve the problems of single effect and poor mechanical properties, and achieve high mechanical properties, good blood compatibility and tissue compatibility, The effect of promoting wound healing

Inactive Publication Date: 2017-03-29
JIANGSU AIXISHI TECH SERVICE CONSULTATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the current absorbable thread used in surgery, the mechanical properties are poor, and the effect is relatively simple

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A silk fibroin suture with the effect of promoting wound healing, made of the following raw materials in parts by weight: 65 parts of polyethylene glycol acid, 20 parts of silk powder, 5 parts of glycerin, 3 parts of lotus root protein, and Panax notoginseng 3 parts of Polygonum multiflorum powder, 10 parts of Polygonum multiflorum powder, 4 parts of ethyl acetate, 2 parts of binder, 11 parts of Dalbergia powder, 3 parts of Hirudin, 5 parts of Polyethylene Glycol Monostearate, 10 parts of Yuanhu, seaweed 11 parts of sodium bicarbonate, 11 parts of iodopropynyl butyl carbamate, 10 parts of angelica powder, and 5 parts of cactus extract.

[0013] The rhubarb root is the rhizoma rhizome powder obtained by superfine pulverization of dry rhubarb root.

[0014] The binder is guar gum or carrageenan.

[0015] Its preparation method is as follows: Weigh each raw material by weight, add the raw materials into the reaction kettle, ultrasonicate at room temperature for 1-6 hours,...

Embodiment 2

[0018] A silk fibroin suture with the effect of promoting wound healing is made of the following raw materials in parts by weight: 75 parts of polyethylene glycol acid, 40 parts of silk powder, 5-15 parts of glycerin, 8 parts of lotus root protein, 7 parts of Panax notoginseng powder, 14 parts of Polygonum multiflorum powder, 9 parts of ethyl acetate, 9 parts of binder, 14 parts of Dalbergia powder, 5 parts of hirudin, 10 parts of polyethylene glycol monostearate, 15 parts of Yuanhu , 14 parts of sodium alginate, 15 parts of iodopropynyl butyl carbamate, 15 parts of angelica powder, and 11 parts of cactus extract.

[0019] The rhubarb root is the rhizoma rhizome powder obtained by superfine pulverization of dry rhubarb root.

[0020] The binder is guar gum or carrageenan.

[0021] Its preparation method is as follows: Weigh each raw material by weight, add the raw materials into the reaction kettle, ultrasonicate at room temperature for 1-6 hours, then heat and stir for 1-3 h...

Embodiment 3

[0024] A silk fibroin suture with the effect of promoting wound healing is made of the following raw materials in parts by weight: 69 parts of polyethylene glycol acid, 30 parts of silk powder, 5-15 parts of glycerin, 6 parts of lotus root protein, 5 parts of Panax notoginseng powder, 12 parts of Polygonum multiflorum powder, 6 parts of ethyl acetate, 6 parts of binder, 12 parts of Dalbergia powder, 4 parts of hirudin, 7 parts of macrogol monostearate, 13 parts of Yuanhu , 13 parts of sodium alginate, 13 parts of iodopropynyl butyl carbamate, 13 parts of angelica powder, and 8 parts of cactus extract.

[0025] The rhubarb root is the rhizoma rhizome powder obtained by superfine pulverization of dry rhubarb root.

[0026] The binder is guar gum or carrageenan.

[0027] Its preparation method is as follows: Weigh each raw material by weight, add the raw materials into the reaction kettle, ultrasonicate at room temperature for 1-6 hours, then heat and stir for 1-3 hours to obtai...

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PUM

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Abstract

The invention discloses a silk fibroin suture line with the effect of promoting wound healing and a preparation method thereof. The silk fibroin suture line is prepared from 65-75 parts of polyglycolic acid, 20-40 parts of silk fibroin powder, 5-15 parts of gelatin glycerol, 3-8 parts of lotus root protein, 3-7 parts of radix notoginseng powder, 10-14 parts of radix polygoni multiflori powder, 4-9 parts of ethyl acetate, 2-9 parts of an adhesive, 11-14 parts of lignum dalbergiae odoriferae powder, 3-5 parts of hirudin, 5-10 parts of polyethylene glycol mono stearate, 10-15 parts of rhizoma corydalis, 11-14 parts of sodium alginate, 11-15 parts of iodopropynyl butylcarbamate, 10-15 parts of radix angelica sinensis powder and 5-11 parts of a cactus extracting liquid. According to the silk fibroin suture line with the effect of promoting wound healing and the preparation method thereof, the silk fibroin suture line is good in blood compatibility and tissue compatibility and high in mechanical property, has the effect of promoting wound healing and can achieve degradation and absorption, and a degradation product is safe to a human body and has no toxin or irritation to the human body.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to a silk fibroin suture with the effect of promoting wound healing and a preparation method thereof. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suturing, hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. The former has the characteristics of high tensile strength, easy disinfection and sterilization, and low tissue reaction, but it does not degrade in the body, so it needs to be removed after suturing, which is easy to cause secondary pain, infection, and scars; the latter can be degraded in the body. Soluble products are absorbed by the body and gradually excreted out of the body, thereby reducing the suffering of patients. The ideal absorbable suture material in clinical application should meet the f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/00
CPCA61L17/005A61L17/10A61L17/105
Inventor 汪屹
Owner JIANGSU AIXISHI TECH SERVICE CONSULTATION CO LTD
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