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Measurement method for pharmacokinetic parameters based on constant-speed intravenous infusion

A technology of pharmacokinetics and measurement methods, applied in the field of pharmacokinetics, which can solve the problems of low blood drug concentration, large error, and underestimation of the calculation results of the apparent volume of distribution of the drug in the phase of elimination.

Inactive Publication Date: 2017-03-29
XI AN JIAOTONG UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Therefore, the elimination half-life of the drug obtained by 5mL of blood collection must be very different from the actual one.
[0016] (3) The blood drug concentration of the elimination phase is low and the error is large
[0019] However, the current calculation of the apparent volume of distribution of the drug does not pay attention to this key point, but the blood concentration at zero time of intravenous injection is used for calculation instead of the blood concentration at zero time of distribution equilibrium
Its value is significantly greater than the blood drug concentration at zero equilibrium of the drug distribution, which results in the obvious underestimation of the calculation results of the apparent volume of distribution of the drug

Method used

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  • Measurement method for pharmacokinetic parameters based on constant-speed intravenous infusion
  • Measurement method for pharmacokinetic parameters based on constant-speed intravenous infusion
  • Measurement method for pharmacokinetic parameters based on constant-speed intravenous infusion

Examples

Experimental program
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Effect test

Embodiment 1

[0081] Embodiment 1: Determination of its main pharmacokinetic parameters by slow and constant intravenous infusion of levofloxacin

[0082] Male SD rats, weighing 360 g, were provided by the Experimental Animal Center of Xi'an Jiaotong University. Rats were anesthetized by intraperitoneal injection of 10% chloral hydrate, the neck, head and back were depilated in a small area, the skin of the neck was cut, the jugular vein and carotid artery were separated, respectively intubated and fixed. Suture the wound and wear a vest. The arteriovenous cannula is passed subcutaneously to the back incision, and the venous cannula is connected to the infusion pump through the spring tube on the back of the vest. The arterial tube is adhered to the spring tube to facilitate blood collection. The upper end of the spring tube is fixed above the mouse cage to ensure that the rats can move freely and cannot grasp and bite the intubation tube. Use the RM-1200 intravenous microinjection pump t...

Embodiment 2

[0102] Embodiment 2: Determination of its main pharmacokinetic parameters after slow and constant intravenous infusion of ornidazole

[0103] Male SD rats, weighing 350 g, were provided by the Experimental Animal Center of Xi'an Jiaotong University. Rats were anesthetized by intraperitoneal injection of 10% chloral hydrate, the neck, head and back were depilated in a small area, the skin of the neck was cut, the jugular vein and carotid artery were separated, respectively intubated and fixed. Suture the wound and wear a vest. The arteriovenous cannula is passed subcutaneously to the back incision, and the venous cannula is connected to the infusion pump through the spring tube on the back of the vest. The arterial tube is adhered to the spring tube to facilitate blood collection. The upper end of the spring tube is fixed above the mouse cage to ensure that the rats can move freely and cannot grasp and bite the intubation tube. Ornidazole and sodium chloride injection (specif...

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Abstract

The invention discloses a measurement method for pharmacokinetic parameters based on constant-speed intravenous infusion and belongs to the technical field of pharmacokinetics. The measurement method comprises the steps that (1) a medicine is infused through a vein at a constant speed till a steady state is reached; (2) blood is sampled in another vein at different time points, and the plasma concentrations in the blood at the different time points are measured; (3) the plasma concentrations at the different time points in the step (2) and corresponding time are subjected to exponential regression, and the steady state plasma concentration and the elimination rate constant are calculated; (4) the elimination half life of the medicine is calculated based on the elimination rate constant obtained through slow constant-speed intravenous infusion in the step (3); and (5) the apparent distribution volume and the clearance rate of the medicine are obtained through calculating based on the steady state plasma concentration obtained through slow constant-speed intravenous infusion in the step (3) and the total amount of the medicine in a body in the steady state. The measurement method is reasonable in design, easy to operate and more accurate in calculation result.

Description

technical field [0001] The invention belongs to the technical field of pharmacokinetics, and in particular relates to a method for measuring pharmacokinetic parameters based on constant-rate intravenous infusion. Background technique [0002] Pharmacokinetics, referred to as pharmacokinetics, is a discipline that studies the changes of drugs in the body. Its main content includes the in vivo process of drugs and the law of drug concentration in vivo, especially the change of blood drug concentration with time. The transport and transformation of drugs cause the concentration of drugs in organs, tissues, and body fluids to change over time. This dynamic process is called the kinetic process or rate process of drugs. This process is very complicated. In order to facilitate the understanding of this dynamic change, a number of pharmacokinetic parameters can be deduced by using the model and functional equation of drug distribution and elimination by drawing curves and establis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/4839
Inventor 曹蕾曹永孝于瑞红米燕妮肖雪张瑞杨晓莉刘静
Owner XI AN JIAOTONG UNIV
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