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Medical titanium alloy preparation method

A technology of titanium alloys and mixtures is applied in the field of preparation of medical titanium alloys, which can solve the problem of bacterial infection at the implantation site, and achieve the effect of inhibiting the growth of bacteria, less equipment investment, and good osteogenesis.

Active Publication Date: 2017-03-22
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Titanium implants also have some problems in surgical operations, such as bacterial infection at the implant site during the operation and for a period of time after the operation

Method used

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  • Medical titanium alloy preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Dissolve 60mg of PLGA (polylactic-co-glycolic acid copolymer), 6.5mg of Pluronic F-68 in 2ml of dichloromethane, 40Hz ultrasonic vibration for 10min, then completely dissolve 100mg of antibiotic in 0.5mL of deionized water, and then dissolve the antibiotic Add the solution into the PLGA (polylactic-co-glycolic acid) solution, shake it upside down, so that the PLGA (poly-lactic-co-glycolic acid) solution fully wraps the drug to form a primary emulsion, and then add 5.5mL of 25mg / mL to the primary emulsion Polyvinyl alcohol solution, 40Hz ultrasonic oscillation for 10min, slowly inject the mixed solution into 34.5mL of 25mg / mL polyvinyl alcohol solution after oscillation, gently stir with a magnetic stirrer for 20h, and finally obtain powdery white particles similar to salt in the lower layer of the solution. Put this solution into a centrifuge tube, centrifuge at a speed of 5000r / min for 30min, wash with deionized water, centrifuge three times, collect the particles, ...

Embodiment 2

[0044](1) Dissolve 50mg of PLGA (polylactic-co-glycolic acid) and 6mg of Pluronic F-68 in 2ml of dichloromethane, 30Hz ultrasonic vibration for 8min, then completely dissolve 90mg of antibiotics in 0.4mL of deionized water, and then dissolve the antibiotic solution Add to the PLGA (polylactic-co-glycolic acid) solution, shake up and down gently, so that the PLGA (poly-lactic-co-glycolic acid) solution fully wraps the drug to form a primary emulsion, and then add 5 mL of 25 mg / mL polyethylene to the primary emulsion Alcohol solution, 30Hz ultrasonic oscillation for 8min, slowly inject the mixed solution into 34mL of 25mg / mL polyvinyl alcohol solution after oscillation, gently stir with a magnetic stirrer for 18h, and finally obtain powdery white particles similar to salt in the lower layer of the solution. Put this solution into a centrifuge tube, centrifuge at a speed of 5000r / min for 20min, wash with deionized water, centrifuge three times, collect the particles, and vacuum fr...

Embodiment 3

[0048] (1) Dissolve 70mg of PLGA (polylactic acid glycolic acid copolymer), 7mg of Pluronic F-68 in 2ml of dichloromethane, 50Hz ultrasonic vibration for 12min, then completely dissolve 110mg of antibiotics in 0.6mL of deionized water, and then dissolve the antibiotic solution Add to the PLGA (polylactic-co-glycolic acid) solution, shake up and down gently, so that the PLGA (poly-lactic-co-glycolic acid) solution fully wraps the drug to form a primary emulsion, and then add 6mL of 25mg / mL polyethylene to the primary emulsion Alcohol solution, 50Hz ultrasonic oscillation for 12min, after oscillation, slowly inject the mixed solution into 35mL of 25mg / mL polyvinyl alcohol solution, stir gently with a magnetic stirrer for 22h, and finally obtain powdery white particles similar to salt in the lower layer of the solution. Put this solution into a centrifuge tube, centrifuge at a speed of 5000r / min for 40min, wash with deionized water, centrifuge 3 times, collect particles, and vacuu...

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Abstract

The invention discloses a medical titanium alloy preparation method, the method comprises the steps of preparing nanometer particles of PLGA (Poly Lactic-co-Glycolic Acid) drug load with evenly distributed particle diameters and relatively light agglomeration degree using the double emulsion method, enabling the nanometer particles to have excellent bioactivity and bacteria resistance, then linking up the nanometer particles with APTES (3-aminopropyltriethoxysilane) layer using the reflux condensation method and using the hydrothermal process treated titanium alloy as the raw material, prompting the nanometer particles of the PLGA (Poly Lactic-co-Glycolic Acid) drug load to connect with titanium based surfaces better, and enabling the nanometer particles to have excellent osseous contributions as well as certain bacterial killing function. When the organism incurs medical infection in applications of the prepared medical titanium alloy, the ester linkages on the surface of the nanometer particles of the PLGA (Poly Lactic-co-Glycolic Acid) drug load open and the drug substances are gradually released with the degradation of the PLGA (Poly Lactic-co-Glycolic Acid), to inhibit bacterium growth and promote the proliferation and differentiation of osteoblast.

Description

technical field [0001] The invention relates to the technical fields of material science and nanometer materials, in particular to a preparation method of medical titanium alloy. Background technique [0002] Biomedical materials are for medical purposes, used to contact living tissues to form functional inanimate materials, including biocompatible or biodegradable materials, which must have good biocompatibility, good biological Stability or controllable degradation and absorption performance, biological activity to form biological bonds with tissues, sufficient strength and toughness or mechanical properties matching with tissues, and good processing, sterilization and clinical operation performance, etc. Titanium-based biomaterials are widely used in orthopedic surgery due to their low modulus, good corrosion resistance, and excellent biodegradability. [0003] Titanium implants also have some problems in surgical operations, such as bacterial infection prone to occur at...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/18A61L27/22A61L27/54
Inventor 吴水林刘泽慧刘想梅谢显洲
Owner HUBEI UNIV
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