Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation and Quality Standard Detection Method of Cordyceps Qishen Capsules

A technology of Cordyceps and capsules, which is applied in the field of preparation and quality standard detection of Cordyceps Qishen Capsules, can solve the problems of easy rejection, loss of active ingredients, single preparation method, etc., achieve simple and feasible preparation method, avoid the loss of ingredients, good effect

Active Publication Date: 2020-03-24
XIANGYU PHARMA
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant found in the pharmaceutical process that the preparation method of the drug is relatively simple, and the same extraction process is used for various raw materials, which has the defect of loss of active ingredients, and the Cordyceps Qishen Capsules need to be taken 4 capsules each time, three times a day, and the dosage is too large , some patients find it hard to accept and prone to rejection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation and Quality Standard Detection Method of Cordyceps Qishen Capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation method of Cordyceps Qishen Capsules comprises the steps of:

[0022] 1) Take 140g of Cordyceps sinensis, crush it into fine powder of Cordyceps sinensis;

[0023] 2) Take 1400g of astragalus, crush it, pass through a 200-mesh sieve, put it in a container, add twice the weight of 85% (v / v) ethanol, stir and extract at 200rpm, control the microwave power to 600W during the extraction process, and the extraction time is 50min Then place it at 4°C for 12 hours, filter, and filter the residue for later use; the filtrate is evaporated under reduced pressure to recover ethanol, and the filtrate is concentrated to extract A with a density of 1.2g / ml; the content of astragaloside IV is 1.27mg by high performance liquid chromatography / ml;

[0024] Add twice the weight of water to the filter residue, stir well, then add 0.5wt% neutral protease (200,000 U / g), enzymatically hydrolyze at 37°C for 120min, then boil for 5min, then add anhydrous Ethanol, stirred at 30...

Embodiment 2

[0038] Cordyceps Qishen Capsule GPM workshop prescription and quality standard test of the present invention are shown in Table 1-2:

[0039] Table 1

[0040] name Dosage kg storage requirements Cordyceps sinensis 67.2 Store in a cool and dry place, away from moths Astragalus 672 Store in a ventilated and dry place, moisture-proof, moth-proof Danshen 268.8 keep in a dry place safflower 268.8 Store in a cool dry place, moisture-proof, moth-proof Suanzaoren 134.4 Store in a cool and dry place, away from moths starch Appropriate amount Keep tightly closed and store in a dry place. empty capsule 480,000 tablets Sealed and stored at a temperature of 10-25°C and a relative humidity of 35-65%.

[0041] Table 2

[0042]

Embodiment 3

[0044] Animal Toxicity Test

[0045] 40 healthy Kunming strain mice, half male and half female, body weight 18.3±1.9g, 40 mice were randomly divided into two groups, each group was half male and half male, of which 20 were the control group and fed with normal water; the other 20 Only mouse is given the capsule preparation prepared by embodiment 1, dosage is 200mg / kg, three times every day, application mouse carries out toxicity experiment and shows: compare with matched group, after administration, mouse does not see significant difference, experiment observes continuously for two weeks, The general condition, food intake, drinking water and weight gain of the mice were normal. On the day of administration and within two weeks after administration, no animal died, suggesting that the drug has low toxicity and is safe for clinical use.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of traditional Chinese herbal medicine extraction and discloses a preparation and quality standard detection method of cordyceps sinensis, astragalus membranaceus and salvia miltiorrhiza capsules. The method comprises the following steps: 1) preparing cordyceps sinensis fine powder; 2) preparing an astragalus membranaceus extractum; 3) preparing a salvia miltiorrhiza and safflower extractum; 4) preparing a spina date seed extractum; and 5) mixing uniformly, drying and pelleting. According to the preparation method provided by the invention, the effective components of the raw materials can be extracted completely, waste of the raw materials is avoided and the medicine effect is more excellent than that of an existing capsule preparation.

Description

technical field [0001] The invention belongs to the technical field of Chinese herbal medicine extraction, and in particular relates to the preparation of Cordyceps Qishen Capsules and a quality standard detection method. Background technique [0002] Cordyceps Qishen Capsules are mainly prepared from Cordyceps sinensis, Astragalus root, Salvia miltiorrhiza, safflower and wild jujube kernels. It has the functions of nourishing the lungs and kidneys, promoting blood circulation and removing blood stasis. It is suitable for syndromes such as lung and kidney qi deficiency and blood stasis caused by chronic nephritis patients. Cordyceps Qishen Capsule is an effective drug for treating chronic nephritis. Its raw material composition is relatively simple, its effect is good, and its toxic and side effects are small, so it is favored by patients. The applicant found in the pharmaceutical process that the preparation method of the drug is relatively simple, and the same extraction ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61K9/48A61P13/12G01N33/15
CPCA61K9/4866A61K36/068A61K36/286A61K36/481A61K36/537A61K36/725A61K2236/19A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53G01N33/15A61K2300/00
Inventor 林祥宇吴士平孙永喜刘倩万照东
Owner XIANGYU PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com