Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Acotiamide hydrochloride membrane controlled slow release preparation and preparation method thereof

A technology for acotiamide hydrochloride and sustained-release preparations, which is applied in the field of acotiamide hydrochloride film-controlled sustained-release preparations and its preparation, can solve the problems of easy forgetting and poor compliance, and achieve the goal of improving solubility and dissolution rate Effect

Inactive Publication Date: 2017-03-15
福建生物工程职业技术学院
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients need to take medicine frequently, and need to control taking it before meals, it is very easy to forget, and the compliance is poor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Acotiamide hydrochloride membrane controlled slow release preparation and preparation method thereof
  • Acotiamide hydrochloride membrane controlled slow release preparation and preparation method thereof
  • Acotiamide hydrochloride membrane controlled slow release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A film-controlled sustained-release preparation of acotiamide hydrochloride is composed of highly soluble acotiamide hydrochloride intermediates and coating components; it includes the following raw materials in parts by weight:

[0019] Table 1 Formula for preparing 1000 drug-containing tablet cores

[0020]

[0021] Its preparation process is:

[0022] (1) Preparation of highly soluble acotiamide hydrochloride intermediate: Dissolve acotiamide hydrochloride in 2.5 times the volume of ethanol solution, add polyoxyethylene stearate melted in a water bath at 60~70°C, mix and stir Evenly, dry in a vacuum oven at 40°C for 24 hours;

[0023] (2) Preparation of drug-containing tablet cores: Take out the highly soluble acotiamide hydrochloride intermediate obtained in step (1), add the prescribed amount of micropowder silica gel to grind (micropowder silica gel as a lubricant can reduce the loss of solid dispersion during the grinding process ), passed through an 80-mesh...

Embodiment 2

[0025] A film-controlled sustained-release preparation of acotiamide hydrochloride is composed of highly soluble acotiamide hydrochloride intermediates and coating components; it includes the following raw materials in parts by weight:

[0026] Table 2 The formula for preparing 1000 drug-loaded pellets

[0027]

[0028] Its preparation process is:

[0029] (1) Preparation of highly soluble acotiamide hydrochloride intermediate: Dissolve acotiamide hydrochloride in 1.5 times the volume of ethanol solution, add polyethylene glycol melted in a water bath at 60~70°C, mix and stir evenly, and place Dry in a vacuum oven at 40°C for 24 hours;

[0030] (2) Preparation of drug-loaded pellets: Take out the highly soluble acotiamide hydrochloride intermediate obtained in step (1), add the prescribed amount of micropowder silica gel to grind, pass through an 80-mesh sieve, and mix with lactose, microcrystalline cellulose, etc. Mix evenly by incremental method, add appropriate amount ...

Embodiment 3

[0032] A film-controlled sustained-release preparation of acotiamide hydrochloride is composed of highly soluble acotiamide hydrochloride intermediates and coating components; it includes the following raw materials in parts by weight:

[0033] Table 3 Formula for preparing 1000 drug-loaded pellets

[0034]

[0035] Its preparation process is:

[0036] Add an appropriate amount of microcrystalline cellulose to the binder to make a soft material, and use the extrusion spheronization method to prepare a blank pellet core (or directly use a commercially available blank pellet core); dissolve acotiamide hydrochloride in 1 volume of ethanol In the solution, after the polyethylene glycol is heated in a water bath at 60~70°C until it melts, mix and stir evenly, add 2% hypromellose aqueous solution and stir evenly, adopt the fluidized bed coating method, and dissolve the medicinal solution Spray on the surface of the blank pellet core to prepare drug-loaded pellets; after drying, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an acotiamide hydrochloride membrane controlled slow release preparation and a preparation method thereof. A solid dispersion technology is used for preparing an acotiamide hydrochloride intermediate; then, a slow release material is used for coating to prepare the membrane controlled slow release preparation. The slow release preparation has a good slow release effect.

Description

technical field [0001] The invention belongs to the technical field of chemical drug preparations, and in particular relates to a film-controlled sustained-release preparation of acotiamide hydrochloride and a preparation method thereof. Background technique [0002] Functional dyspepsia refers to a group of clinical syndromes originating from the gastroduodenal area, characterized by postprandial fullness and discomfort, early satiety, epigastric pain or burning sensation in the upper abdomen, and belongs to the category of functional gastrointestinal diseases . This disease is clinical common disease and frequently-occurring disease, accounts for the highest proportion in stomach disease, and the course of disease is long, easy to repeat. Foreign epidemiological studies show that the prevalence of functional dyspepsia is between 20% and 40%. Therefore, functional dyspepsia has always been a research hotspot in the field of digestive diseases. [0003] Altecolamide Hyd...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/426A61K47/10A61K47/14A61P1/14
CPCA61K9/5042A61K9/0002A61K31/426A61K47/10A61K47/14
Inventor 何文胜陈晓英刘立中
Owner 福建生物工程职业技术学院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com