Desonide gel preparation more stable in quality
A desonide gel and stabilization technology, which is applied in the field of pharmaceutical preparations, can solve problems such as uneven content and obvious sedimentation of active ingredients, and achieve the effects of improving obvious sedimentation, uniform and stable content, and excellent stability of chemical properties
Inactive Publication Date: 2017-03-08
CHONGQING HUAPONT PHARMA
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Problems solved by technology
[0004] In view of this, one of the purposes of the present invention is to provide a method for improving the stability of desonide gel preparations, which can improve the defects of obvious active ingredient sedimentation and uneven content in existing preparations
Method used
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Embodiment 1
[0036] The desonide gel of the present embodiment, its composition is as follows:
[0037]
[0038] Preparation:
[0039] 1) Weigh the purified water, carbomer, glycerin, disodium edetate and phenoxyethanol of the prescribed amount, stir and dissolve completely;
[0040] 2) Add the prescribed amount of desonide into the carbomer solution, stir and disperse homogeneously;
[0041] 3) Add sodium hydroxide solution, stir and mix evenly to obtain a gel.
Embodiment 2
[0043]The desonide gel of the present embodiment, its composition is as follows:
[0044]
[0045] Preparation method: with embodiment 1.
Embodiment 3
[0047] The desonide gel of the present embodiment, its composition is as follows:
[0048]
[0049] Preparation method: with embodiment 1.
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Abstract
The invention belongs to the field of drug preparations and relates to a desonide preparation, in particular to a desonide gel preparation with more uniform active ingredient content and higher stability. The viscosity of the desonide gel preparation is controlled to be 40,000-350,000mPa.s. The desonide gel preparation has high physical stability; after high-temperature, low-temperature and freezing and thawing cycle survey, the active ingredients are suspended in gel and do not have a remarkable sedimentation trend, the product content is excellent and stable in uniformity, and the defects that the active ingredients in an existing desonide gel preparation are remarkable in sedimentation and non-uniform in content are overcome; and the desonide gel preparation has high chemical stability, and related substance control meets existing impurity control standards, so that the desonide gel preparation is superior to existing market products.
Description
technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to a desonide preparation, in particular to a desonide gel preparation with more uniform active ingredient content and better stability. Background technique [0002] Desonide is a glucocorticoid drug, which has anti-inflammatory, anti-allergic, anti-itching and reducing exudation effects; it can reduce and prevent tissue responses to inflammation, and can eliminate local non-infectious inflammation caused by fever, redness and Swelling, thereby reducing the manifestations of inflammation; has an immunosuppressive effect: prevents or suppresses cellular immune responses, suppresses primary immune responses. The topical preparations of desonide can be used for the treatment of various hormone-sensitive skin diseases such as contact dermatitis, neurodermatitis, seborrheic dermatitis, eczema, psoriasis, lichen planus, lichen simplex, sweat blisters and pruritus wait. [0003] ...
Claims
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IPC IPC(8): A61K9/06A61K31/58A61K47/32A61K47/38A61K47/36A61P29/00A61P37/08A61P17/04A61P37/06A61P17/00A61P17/08A61P17/06
Inventor 陈李平管璐晗蒋海龙传娜赵静
Owner CHONGQING HUAPONT PHARMA
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