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A kind of Guizhi granule and its traditional Chinese medicine preparation

A technology of granules and guizhi, which is applied in the field of Guizhi granules and its traditional Chinese medicine preparations, can solve the problems of inability to analyze multiple varieties and batches of samples in real time, physical injury of inspectors, and lag in information feedback, and achieves process parameters and is easy to control. , High accuracy, stable process parameters

Active Publication Date: 2018-08-07
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of moisture and ethanol extracts in Guizhi granules requires several hours with reference to the pharmacopoeia, and the operation is more complicated.
The main chemical component of Guizhi granules is cinnamic acid, which is used as a quality control indicator. Traditional methods use high-performance liquid chromatography, etc., which often require complicated pretreatment of samples, consume a lot of reagents, cause great environmental pollution and are harmful to inspection. Due to the physical injury of the staff, the information feedback is lagging behind, which cannot meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

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  • A kind of Guizhi granule and its traditional Chinese medicine preparation
  • A kind of Guizhi granule and its traditional Chinese medicine preparation
  • A kind of Guizhi granule and its traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of Guizhi Granules: Take Guizhi decoction pieces, add water to decoct 3 times, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; The paste is filtered with a 350-mesh sieve while it is hot; it is spray-dried under the conditions of an air inlet temperature of 150°C, a material pump speed of 700 rpm, an outlet air temperature of 85°C, and an air supply temperature of 40°C to obtain a spray-dried powder; The hole diameter of the orifice plate is 1.50mm, the frequency of the roller motor is 45HZ, the frequency of the feeding motor is 45HZ, and the oil cylinder pressure is 18bar under the conditions of dry granulation to obtain Guizhi granules with a particle size of 40 mesh.

Embodiment 2

[0036] The preparation of the traditional Chinese medicine preparation containing Guizhi granules: take Guizhi decoction pieces, add water to decoct 3 times, add 8 times the amount of water each time, and heat and decoct for 1.5 hours each time; the medicinal liquids are combined, and the filtrate is concentrated to a relative density of 1.08 (80 ℃), filter it with a 350-mesh sieve while it is hot; carry out spray drying under the conditions of air inlet temperature 150 ℃, material pump speed 700 rpm, outlet air temperature 85 ℃, and air supply temperature 40 ℃, and spray Dry powder; dry granulation under the conditions of punching plate aperture 1.50mm, roller motor frequency 45HZ, feeding motor frequency 45HZ, oil cylinder pressure 18bar, to obtain Guizhi granules with a particle size of 40 mesh; mix 120g Guizhi granules with 80g maltodextrin , add an appropriate amount of magnesium stearate, mix well, and press into 1000 tablets.

Embodiment 3

[0038] A method for rapidly detecting the moisture content of cassia twig granules based on near-infrared spectroscopy, specifically comprising the following steps:

[0039] a. Take cinnamon twig granule samples, a total of 47 batches, about 3g each, grind into fine powder, put it into a stoppered glass sample bottle, place it on a near-infrared scanner for scanning, collect spectra, scanning conditions: scanning range 4000-12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum of 47 batches of Guizhi granules shown;

[0040] At the same time, according to the standard method specified in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was measured by the drying method. About 2 g of cassia twig granules that were ground into fine powder were spread flat in a ...

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Abstract

The invention discloses cassia twig granules and a traditional Chinese medicine preparation thereof. The cassia twig granules are prepared according to the following method steps: taking cassia twig decoction pieces, and adding water for decocting for 2-3 times, wherein the adding amount of water is 5-10 times that of the decoction pieces each time, and heating for decocting is performed for 1-2 hours for each time; merging the liquid medicine, concentrating the filtrate into clear paste with relative density of 1.02-1.10, and screening by a sieve with the granularity of 250-350 meshes while the clear paste is hot; performing spray drying on the clear paste, thereby obtaining spray-dried powder; performing dry granulation on the spray-dried powder, thereby obtaining the cassia twig granules with the granularity of 16-40 meshes. The process for preparing the cassia twig granules disclosed by the invention is simple, has easily controllable process parameters, and is a detection method with the advantages of scientificity, rapidness and high operability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a cinnamon twig granule and a traditional Chinese medicine preparation thereof. Background technique [0002] Guizhi is derived from the dry shoots of Cinnamomum cassia Presl, a plant in the family Lauraceae. Harvest in spring and summer, remove leaves, sun-dry, or slice and dry. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of decoction pieces replaces the decoction pieces of traditional Chinese medicine for clinical syndrome differentiation and treatment, addition and subtraction according to the syndrome, and formula use. Compared with the traditional Chinese medicine decoction method of "medic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/54A61K9/16G01N21/359
CPCA61K9/1652A61K36/54A61K2236/331A61K2236/39A61K2236/51G01N21/359
Inventor 王闽予朱德全霍文杰刘丽萍陈向东谭登平程学仁
Owner GUANGDONG YIFANG PHARMA
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