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Hyaluronic acid toothpaste with effects of diminishing inflammation and inhibiting bacteria and preparation method of hyaluronic acid toothpaste

A hyaluronic acid, anti-inflammatory and anti-bacterial technology, which is applied in the direction of medical preparations containing active ingredients, dentistry, digestive system, etc., to achieve good anti-inflammatory effect

Pending Publication Date: 2017-02-22
杭州惠博士生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, besides inflammation, there are also pathogenic bacteria in the oral cavity that cause oral problems. Therefore, a toothpaste with a special composition combined with hyaluronic acid is needed, which can effectively exert synergistic effects, anti-inflammatory and antibacterial, and is widely used for tooth allergies. Bleeding gums, red and swollen gums, mouth ulcers, mouth sensitivity, sore throat and other oral inflammation problems

Method used

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  • Hyaluronic acid toothpaste with effects of diminishing inflammation and inhibiting bacteria and preparation method of hyaluronic acid toothpaste
  • Hyaluronic acid toothpaste with effects of diminishing inflammation and inhibiting bacteria and preparation method of hyaluronic acid toothpaste
  • Hyaluronic acid toothpaste with effects of diminishing inflammation and inhibiting bacteria and preparation method of hyaluronic acid toothpaste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Illustrate the antibacterial effect of toothpaste after using ascorbic acid, composition clear paste and hyaluronic acid compound

[0031] Common oral pathogens are divided into Gram-negative bacteria (Fusobacterium nucleatum etc.) and Gram-positive bacteria (Streptococcus mutans etc.), this experiment takes toothpaste antibacterial ring test to test the antibacterial performance of the present invention, selects Streptococcus mutans suspension, Lactobacillus acidophilus suspension, Fusobacterium nucleatum suspension, and Porphyromonas gingivalis suspension were used as strains, and nutrient agar, tryptone soybean agar and sandbag agar were used as culture medium. The toothpaste prepared in Examples 4, 5, 6 and 7 and blank toothpaste (basic toothpaste without hyaluronic acid, composition clear paste and ascorbic acid) were used for the experimental toothpaste. Weigh 1.0g of toothpaste, add 3ml of deionized water and stir evenly, add 20ul dropwise on sterile f...

Embodiment 2

[0036] Example 2: Studying the different effects of adding ascorbic acid and composition clear cream to hyaluronic acid toothpaste, it shows that the best combination is hyaluronic acid, ascorbic acid and composition clear cream.

[0037] Human body experiments are now used to detect the human biological activity of hyaluronic acid, that is, anti-inflammatory activity, to study the effects of hyaluronic acid, composition clear ointment, and ascorbic acid on eliminating redness and swelling, preventing gingival bleeding and hyperplasia, and treating gingivitis and oropharyngeal mucositis Efficacy for oral inflammation problems.

[0038] All cases in this experiment were patients with oral inflammation. Experimental group 1 used ascorbic acid 1.0% + composition clear cream 30% + hyaluronic acid 1.0% toothpaste to brush teeth twice a day in the morning and evening; experimental group 2 used ascorbic acid 1.0% + hyaluronic acid 1.0% Toothpaste was used to brush teeth twice a day i...

Embodiment 3

[0053] Example 3: Research on the optimal weight percentage ratio of ascorbic acid, composition clear ointment and hyaluronic acid in hyaluronic acid ointment

[0054] Proportioning 0.5%, 1.0%, 1.5% ascorbic acid and 15%, 25%, 35% composition clear paste and 0.5%, 1.0%, 2.0% hyaluronic acid toothpaste, other ingredients are foaming agent, friction Agents and excipients, the total weight percentage of all ingredients is 100%. All the cases in this experiment were patients with oral inflammation. In Experiments 1-27, toothpaste with different concentrations of ascorbic acid, composition clear cream and hyaluronic acid was used to brush teeth twice a day in the morning and evening to conduct an orthogonal experiment with three factors and three levels to observe the situation after treatment; Positive controls 28-30 use 0.5%, 1.0%, and 2.0% hyaluronic acid toothpaste to brush their teeth twice a day, morning and evening, and observe the situation after treatment; 31 is the negati...

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Abstract

The invention discloses hyaluronic acid toothpaste with effects of diminishing inflammation and inhibiting bacteria. The hyaluronic acid toothpaste with effects of diminishing inflammation and inhibiting bacteria is characterized by comprising hyaluronic acid with effects of diminishing inflammation and inhibiting bacteria, ascorbic acid and composition cream; the ascorbic acid and the hyaluronic acid has synergistic effects of diminishing inflammation and inhibiting bacteria; and the composition cream consists of Flos Matricariae chamomillae, green tea, Princepia utilis and Flos Chrysanthemi Indici. The hyaluronic acid toothpaste has good effect of diminishing inflammation, and meanwhile has effect of inhibiting bacteria.

Description

technical field [0001] The invention relates to the field of oral care products, in particular to a hyaluronic acid toothpaste with anti-inflammatory and antibacterial effects and a preparation method thereof. Background technique [0002] Toothpaste is a cleaning product commonly used in daily life and has a long history. Toothpaste can remove stains and plaque on the surface of the teeth, has no irritation to the oral mucosa, and is non-toxic. It is very important for cleaning the oral cavity and maintaining oral health. At present, along with the continuous development of oral cleaning products, the kind of toothpaste is various, has developed into various health-care toothpastes with different functions by the toothpaste of single cleaning effect. It is understood that oral problems such as gingivitis and oropharyngeal mucositis have become a major problem that plagues human beings, and it is imminent to find a safe, efficient and convenient solution. [0003] Studies ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/73A61K8/67A61Q11/00A61P1/02
CPCA61K8/97A61K8/676A61K8/735A61K2800/5922A61Q11/00
Inventor 贺晓军
Owner 杭州惠博士生物科技有限公司
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