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Oral aripiprazole liquid dry suspension agent and preparation method thereof

A technology of aripiprazole and dry suspension, which is applied in the field of medicine and can solve the problems of harm to patients, inconvenient administration, poor stability, etc.

Inactive Publication Date: 2017-02-15
万全万特制药江苏有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to rapid disintegration, orally disintegrating tablets also need to have a good taste. Therefore, a large amount of excellent disintegrants and flavoring agents must be added during tablet compression, so that if the weight and shape of the prepared tablet are too large, it will be inconvenient to take.
Because the injections enter the human body directly and quickly, there is no protection of the normal physiological barrier of the human body. Therefore, if the dosage is improper or the injection is too fast, or there is a problem with the quality of the drug, it may bring harm to the patient and the safety is poor. In addition, the injection will cause pain when it is administered. , generally can not be administered by the patient himself, the administration is inconvenient, and the clinical compliance is poor
Although the oral solution can solve the problem of taking difficulty for patients with weak swallowing ability, it is not stable during taking, and it is inconvenient to carry and take as a liquid preparation

Method used

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  • Oral aripiprazole liquid dry suspension agent and preparation method thereof
  • Oral aripiprazole liquid dry suspension agent and preparation method thereof
  • Oral aripiprazole liquid dry suspension agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013]

[0014] Preparation Process:

[0015] 1) Grinding the aripiprazole, sucrose and xylitol through a 100-mesh sieve for later use;

[0016] 2) Mix the aripiprazole, the above-mentioned sucrose, xylitol, and xanthan gum evenly, add a binder, stir and granulate, dry at 50°C, granulate, and classify to obtain granules for later use;

[0017] 3) Mix the flavoring agent, sodium carboxymethyl starch and the granules prepared in the above 2).

Embodiment 2

[0019]

[0020] Preparation Process:

[0021] 1) Pass the aripiprazole, mannitol, and xylitol through a 100-mesh sieve for later use;

[0022] 2) Mix the aripiprazole with the above-mentioned mannitol, xylitol, and xanthan gum evenly, add a binder, stir and granulate, dry at 50°C, granulate, and classify to obtain granules for later use;

[0023] 3) Mix sucralose, strawberry essence, sodium carboxymethyl starch and the granules prepared in the above 2).

Embodiment 3

[0025]

[0026] Preparation Process:

[0027] 1) Pass the aripiprazole, lactose, and xylitol through a 100-mesh sieve for later use;

[0028] 2) Mix the aripiprazole with the above-mentioned lactose, xylitol, and xanthan gum evenly, then add a binder, stir and granulate, dry at 50°C, granulate, and classify to obtain granules for later use;

[0029] 3) Mix sucralose, orange essence, sodium carboxymethyl starch and the granules prepared in 2) above to get the product.

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Abstract

The invention belongs to the technical field of medicines, and relates to an oral aripiprazole liquid dry suspension agent which is used for treating schizophrenia and is effective for acute recurrent patients, chronic patients and affective schizophrenia patients, and a preparation method thereof. The medicine is prepared from active ingredients of aripiprazole and other pharmaceutically acceptable auxiliary materials of filling agents, suspending agents, corrigents, bonding agents and disintegrating agents. The oral aripiprazole liquid dry suspension agent provided by the invention solves the problems of medicine taking difficultly and poor medicine taking compliance of some patients with weak swallowing ability; in addition, the quality is enabled to be controllable; the stability is high; the taking is convenient; the mouthfeel is good; the clinic requirements can be well met. Compared with known aripiprazole tablets, the oral aripiprazole liquid dry suspension agent has the advantages of high medication speed, fast effect taking, stable absorption, high bioavailability and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to aripiprazole oral dry suspension and a preparation method thereof. The preparation of the invention is mainly used for treating various types of schizophrenia, has obvious curative effect on both positive and negative symptoms of schizophrenia, can improve accompanying emotional symptoms, and reduce the relapse rate of schizophrenia. Background technique [0002] Aripiprazole (7-{4-[4-(2,3-dichlorophenyl)-l-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone ) is a stabilizer of dopamine and serotonin systems, a blocker of post-synaptic dopamine receptors, and an agonist of pre-synaptic autonomic receptors. It has a very strong affinity with D2 and D3 receptors, and at the same time As a partial agonist of D2 receptors, it shows a strong blocking effect in the model of dopamine hyperfunction in vivo, while it shows a strong agonist effect in the model of dopamine hypo...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/496A61K47/38A61K47/36A61K47/26A61P25/18A61P25/22A61P25/24
CPCA61K9/0095A61K9/1623A61K9/1652A61K31/496
Inventor 王亚丽马莉
Owner 万全万特制药江苏有限公司
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