High-density micropill core and preparation method thereof

A high-density, pellet technology, applied in the field of medicine, can solve the problems of non-compliance with energy conservation and environmental protection, low yield, large energy, etc., and achieve the effects of high yield, low friability, and high density

Inactive Publication Date: 2017-02-01
GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method is that the main material composition is mixed with a binder and made into a nearly round granule in a granulator, then dried and sieved to form a pellet core, wherein the main material composition consists of sucrose fine powder and Medicinal starch is mixed or selected from starch or microcrystalline cellulose alone. The binder is mainly syrup. The pellet core prepared in this invention has strong hygroscopicity because it contains sucrose, and the yield is not high. It needs to consume a lot of energy, which is not in line with the concept of energy conservation and environmental protection at the present stage

Method used

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  • High-density micropill core and preparation method thereof
  • High-density micropill core and preparation method thereof
  • High-density micropill core and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036] By adopting the preparation method of the present invention, a high-density pellet core is prepared by using calcium carbonate powder (median particle diameter of 5 μm) and microcrystalline cellulose as the main material composition and hydroxypropylmethyl cellulose as a binder. The formulation of the high-density pellet core of this example is shown in Table I.

[0037] Table I

[0038]

[0039] Preparation method: Weigh the materials according to the amounts shown in Table I, heat the purified water to about 80°C, slowly add hydroxypropyl methylcellulose E50 to the hot purified water, add while stirring, and dissolve the binder solution. Cool to room temperature for use; put the weighed calcium carbonate powder and microcrystalline cellulose in a high-efficiency wet mixing granulator, set the mixing rate to 300RPM, and the shear rate to 1000RPM, turn on the mixing shear, and mix and shear for 3 minutes Then slowly add the adhesive solution. After adding the adhesive solut...

Embodiment 2

[0042] By adopting the preparation method of the present invention, a high-density pellet core is prepared by using calcium carbonate powder (median particle diameter of 5 μm) and microcrystalline cellulose as a main material composition and polyethylene glycol 6000 as a binder. The formulation of the high-density pellet core of this embodiment is shown in Table II

[0043] Table II

[0044]

[0045] Preparation method: Weigh the materials according to the amount shown in Table II, slowly add polyethylene glycol 6000 to purified water, add while stirring, and stir until it is clear and transparent to obtain a binder solution, set aside; weigh it well Calcium carbonate powder and microcrystalline cellulose are placed in a high-efficiency wet mixing granulator, the mixing rate is set to 300RPM, the shear rate is 1000RPM, the mixing and shearing are turned on, and the binder solution is slowly added after mixing and shearing for 3 minutes to bond After adding the agent solution, set ...

Embodiment 3

[0048] By adopting the preparation method of the present invention, a high-density pellet core is prepared by using calcium carbonate powder (median particle size of 5 μm) and microcrystalline cellulose as the main material composition and hydroxypropyl cellulose as a binder. The formulation of the high-density pellet core of this example is shown in Table III.

[0049] Table III

[0050]

[0051] Preparation method: Weigh the materials according to the amount shown in Table III, slowly add the hydroxypropyl cellulose to the purified water, add while stirring, and stir until it is clear and transparent to obtain the binder solution, set aside; weigh it well The calcium carbonate powder and microcrystalline cellulose are placed in a high-efficiency wet mixing granulator, the mixing rate is set to 300RPM, the shear rate is 1000RPM, the mixing and shearing are turned on, and the binder solution is slowly added after mixing and shearing for 3 minutes to bond After adding the agent sol...

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Abstract

The invention relates to a high-density micropill core and a preparation method thereof. The high-density micropill core is prepared from the following raw materials in percentage by weight: 60%-96% of main ingredient composition, 1%-10% of adhesive and 2%-30% of solvent, wherein the main ingredient composition is prepared by mixing the following components in percentage by weight: 20%-90% of calcium carbonate and 10%-80% of microcrystalline cellulose. The high-density micropill core disclosed by the invention has the advantages of simple preparation process, high yield, low friability, uniform particle size, good roundness and high surface smoothness, and is applicable to sustained release preparations such as pill core administration, micropill tabletting and the like. The high-density micropill core presents weak alkalinity due to the higher content of calcium carbonate, and therefore is applicable to preparing micropill preparation of alkaline medicines such as omeprazole and the like. The high-density micropill core not only can assist in the development of sustained release preparations in China, but also can be taken directly as high-level calcium supplementing preparation to fill capsules, and moreover has a calcium supplementing effect.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a high-density pellet core and a preparation method thereof. Background technique [0002] Sustained and controlled release pellets, as a high-standard sustained and controlled release preparation, have developed rapidly in China in recent years. Compared with general preparations, it has three characteristics: First, it is convenient to take, and general preparations require several doses per day. It usually only needs to be administered 1-2 times a day; the second is that its effect is slower than that of general preparations, which avoids the sudden increase of effective blood concentration due to excessive fluctuations in blood concentration after frequent administration of general preparations Suddenly, the effect of the drug is improved and the toxic and side effects are reduced; third, the quality of the sustained-release pellet preparation is more stable and the difference be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/38A61K33/10A61P3/14
CPCA61K9/1652A61K9/0002A61K33/10
Inventor 吴传斌陈航平李革潘文杰杨思超胡春丽张林杰
Owner GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK
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