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Serum miRNA marker related to auxiliary diagnosis for squamous lung cell carcinoma and application thereof

A technology for auxiliary diagnosis and lung squamous cell carcinoma, applied in the fields of genetic engineering and oncology, it can solve the problems of lack of sensitivity and specificity, high false alarm rate, overdiagnosis, etc., and achieve high sensitivity and specificity and good stability. , the effect of minimally invasive acquisition

Active Publication Date: 2017-01-25
朱伟
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Problems solved by technology

However, its use is limited due to reasons such as high false positive rate, potential overdiagnosis, high cost, and possible radiation exposure hazards.
At present, the most widely used tumor markers in clinical practice, such as squamous cell carcinoma antigen (SCC), carcinoembryonic antigen (CEA), neuronspecific enolase (NSE) and Cyfra 21-1, also lack certain sensitivity and specificity

Method used

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  • Serum miRNA marker related to auxiliary diagnosis for squamous lung cell carcinoma and application thereof
  • Serum miRNA marker related to auxiliary diagnosis for squamous lung cell carcinoma and application thereof
  • Serum miRNA marker related to auxiliary diagnosis for squamous lung cell carcinoma and application thereof

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Embodiment Construction

[0035] The inventor collected a large number of venous serum samples from the First Affiliated Hospital of Nanjing Medical University from 2012 to 2015, and selected 100 cases of lung squamous cell carcinoma and 108 cases of The normal control sample was used as the experimental sample for the initial screening of Exiqon miRNA qPCR panel chip and subsequent series of qRT-PCR verification. At the same time, 32 cases of lung squamous cell carcinoma tissues and 36 cases of paracancerous tissues were retained. The selected patients' serum samples were all from newly diagnosed patients who had not undergone surgery, radiotherapy and chemotherapy, and were pathologically confirmed as squamous cell carcinoma of the lung. The demographic data and clinical data of these samples were collected systematically.

[0036] Refer to the flowchart ( figure 1 ), randomly selected 30 cases of lung squamous cell carcinoma samples and 10 cases of normal controls from the serum samples of lung sq...

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Abstract

The invention discloses a serum miRNA marker related to auxiliary diagnosis for squamous lung cell carcinoma and an application thereof. The marker is one or more of miR-106a-5p, miR-20a-5p and miR-93-5p. As a novel biomarker, the serum miRNA has the characteristics of high stability, minimal invasion, easiness in acquiring, sensitivity and specificity. Such a molecular marker can be developed and utilized to supply a new direction for diagnosing and further treating various diseases including tumor. According to the research, the serum miRNA marker for squamous lung cell carcinoma with clinical diagnosis potential can be more specifically acquired. The research proves that the miRNA as a noninvasive marker for diagnosing the squamous lung cell carcinoma has reliability and repeatability.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a serum miRNA marker related to the auxiliary diagnosis of lung squamous cell carcinoma and its application. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world. In China, the morbidity and mortality of lung cancer rank first. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers. Among them, squamous cell carcinoma of the lung is one of the most common subtypes of NSCLC. Although surgical treatment is currently the first choice and the most important treatment for squamous cell carcinoma of the lung, and can achieve the goal of curing early squamous cell carcinoma of the lung, the early diagnosis rate in my country is still low due to the lack of specificity in the early clinical manifestations of squamous cell carcinoma of the lung. lower. At present, low-dose computed tomography (LDCT) i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/113C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 朱伟单霞尹荣朱军张澜黄泽波张获朱丹霞吴俚蓉周鑫刘平
Owner 朱伟
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