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Visible light initiating system in medical photocurable hydrogel and photocuring method thereof

A triggering system and hydrogel technology, applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, prostheses, etc., can solve the problems of unfavorable cell growth, increased N-vinylpyrrolidone content, etc., to promote cell proliferation, good Good solubility and biocompatibility

Active Publication Date: 2017-12-22
GANSU JINDUN CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results of cytotoxicity study showed that the hydrogel dressing has good cytocompatibility, but the increase of N-vinylpyrrolidone content is not good for cell growth

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A visible light initiating system that initiates hydrogel photocuring, its components are as follows:

[0027] The first component: camphorquinone 0.5%,

[0028] The second component: sericin powder with a molecular weight of 3000Da 1%.

[0029] Prepare the visible light triggering system according to the above ratio, and add the visible light triggering system to the hydrogel precursor solution containing 30% acrylamide / methylenebisacrylamide (29:1, w / w) The hydrogel precursor solution is fully mixed to obtain a transparent and clear photocuring reaction solution.

[0030] Photopolymerization reaction: The prepared photocurable hydrogel precursor solution was placed in a sealed transparent glass test tube and irradiated under a visible light source for 10 Min. The distance between the light source and the test tube was about 7cm. After the irradiation, the test tube was inverted to observe the curing result of the hydrogel.

Embodiment 2

[0032] A visible light initiating system that initiates hydrogel photocuring, its components are as follows:

[0033] The first component: riboflavin 0.5%,

[0034] The second component: sericin powder with a molecular weight of 3000Da 1%.

[0035] The preparation method of the hydrogel precursor is the same as in Example 1.

[0036] The photopolymerization reaction was the same as in Example 1.

Embodiment 3

[0038] A visible light initiating system that initiates hydrogel photocuring, its components are as follows:

[0039] The first component: Eosin Y 0.5%,

[0040] The second component: sericin powder with a molecular weight of 3000Da 1%.

[0041] The preparation method of the hydrogel precursor is the same as in Example 1.

[0042] The photopolymerization reaction was the same as in Example 1.

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Abstract

The invention relates to the technical field of photo-curing hydrogels, and in particular relates to a visible light initiating system in a medical photo-curing hydrogel and a photo-curing method thereof. The visible light initiating system in the medical photo-curing hydrogel contains the following components in part by weight: 0.5-1 part of the first component: photosensitizer, and 0.5-5 parts of the second component: auxiliary initiator; the auxiliary initiator is water-soluble sericin or fibroin powder, the photosensitive synergist is one of iodonium salt, sulfoniumsalt or phosonium salt. The system is good in solubleness in water, and excellent in biocompatibility or biosecurity; and the free radical produced after absorbing 400-700nm of visible light can efficiently initiate the polymerization and curing of the precursor aqueous solution containing unsaturated double bond, thereby preparing the multipurpose medical hydrogel.

Description

technical field [0001] The invention relates to the technical field of photocurable hydrogels, in particular to a visible light initiating system in medical photocurable hydrogels and a photocuring method thereof. Background technique [0002] Hydrogel is a kind of hydrophilic polymer that can absorb a large amount of water but cannot dissolve in water. It has good biocompatibility, and hydrophilic small molecular substances can be dissolved and diffused in it. Compared with hydrophobic polymers, hydrogels have much weaker interactions with the enzymes or cells contained in them. Therefore, the biomolecules immobilized in hydrogels can remain active for a longer period of time, making them suitable for use in biological systems. There are many uses in fields such as chemistry and medicine. There are many methods for the preparation of hydrogels, mainly including chemical cross-linking and copolymerization reactions, cross-linking reactions of polymer precursors, polymer-pol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F2/50C08F220/56C08F222/38C08F299/02C08J3/075A61L15/26A61L15/42A61L27/18A61L27/52A61K47/32
CPCA61K47/34A61L26/0019A61L26/008A61L27/18A61L27/52C08F2/50C08F220/56C08F299/028C08J3/075C08J2333/26C08J2353/00C08F222/385C08L33/26C08L53/00
Inventor 南旭莹邵建中范钦国黄益姚玉华
Owner GANSU JINDUN CHEM
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