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Preparation method of photothermal response type composite gel hollow microsphere

A composite gel and hollow microsphere technology, applied in the chemical industry, achieves good dispersion, mild reaction conditions, and simple operation

Active Publication Date: 2017-01-11
SHANGHAI INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, there are few reports in the open literature on the preparation of polymer hollow spheres with dual photothermal responses. Therefore, it is of great significance to carry out research on polymer hollow spheres with dual photothermal responses.

Method used

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  • Preparation method of photothermal response type composite gel hollow microsphere

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Embodiment 1

[0022] A photothermal responsive composite gel hollow microsphere, characterized in that the photothermal responsive composite gel hollow microsphere is made of SiO 2 Solid spheres as templates, and P(NIPAM-AM) / SiO with core-shell structure prepared by surface graft polymerization 2 Composite gel microspheres, followed by HF etching of SiO 2 template to form P(NIPAM-AM) gel hollow microspheres, and use the gel hollow microspheres as microreactors to prepare photothermally responsive composite gel hollow microspheres loaded with AuNRs in situ. The type composite gel hollow microspheres are used in the DOX phosphate buffer solution system to realize the effective controlled release of the loaded substance DOX under the conditions of near-infrared light and temperature.

[0023] The preparation method of photothermal responsive composite gel hollow microspheres comprises the following steps:

[0024] (1) Add 8.5 mL of NH with a mass fraction of 25-28% 3 ·H 2 O, 15 mL C 2 h ...

Embodiment 2

[0034] A photothermal responsive composite gel hollow microsphere, characterized in that the photothermal responsive composite gel hollow microsphere is made of SiO 2 Solid spheres as templates, and P(NIPAM-AM) / SiO with core-shell structure prepared by surface graft polymerization 2 Composite gel microspheres, followed by HF etching of SiO 2 template to form P(NIPAM-AM) gel hollow microspheres, and use the gel hollow microspheres as microreactors to prepare photothermally responsive composite gel hollow microspheres loaded with AuNRs in situ. The type composite gel hollow microspheres are used in the DOX phosphate buffer solution system to realize the effective controlled release of the loaded substance DOX under the conditions of near-infrared light and temperature.

[0035] The preparation method of photothermal responsive composite gel hollow microspheres comprises the following steps:

[0036] (1) Add 9.5 mL of 25%-28% NH 3 ·H 2 O, 17 mL C 2 h 5 OH and 25mL H 2 O wa...

Embodiment 3

[0046] A photothermal responsive composite gel hollow microsphere, characterized in that the photothermal responsive composite gel hollow microsphere is made of SiO 2 Solid spheres as templates, and P(NIPAM-AM) / SiO with core-shell structure prepared by surface graft polymerization 2 Composite gel microspheres, followed by HF etching of SiO 2 template to form P(NIPAM-AM) gel hollow microspheres, and use the gel hollow microspheres as microreactors to prepare photothermally responsive composite gel hollow microspheres loaded with AuNRs in situ. The type composite gel hollow microspheres are used in the DOX phosphate buffer solution system to realize the effective controlled release of the loaded substance DOX under the conditions of near-infrared light and temperature.

[0047] The preparation method of photothermal responsive composite gel hollow microspheres comprises the following steps:

[0048] (1) Add 8.8 mL of NH with a mass fraction of 25%-28% 3 ·H 2 O, 16 mL C 2 h ...

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Abstract

The invention discloses a preparation method of photothermal response type composite gel hollow microsphere. Silica solid spheres are used as templates, poly (N-isopropylacrylamide-acrylamide) / silica gel composite microsphere with a core-shell structure can be prepared through surface graft polymerization, and silica templates are etched by hydrofluoric acid to form poly (N-isopropylacrylamide-acrylamide) gel hollow microspheres; by using the poly (N-isopropylacrylamide-acrylamide) gel hollow microsphere as a microreactor, the gold nanorod loaded photothermal response composite gel hollow microspheres can be prepared by in-situ reduction; the photothermal response composite gel hollow microspheres are used in doxorubicin hydrochloride phosphate buffer solution system to achieve the effective controlled releasing of doxorubicin hydrochloride in the conditions of near-infrared light and temperature.

Description

technical field [0001] The invention belongs to the field of chemical industry and relates to a hollow gel microsphere, in particular to a method for preparing a photothermal responsive composite gel hollow microsphere. Background technique [0002] Polymer hollow sphere is a functional material with a special structure. Hollow spheres with nanometer or micron particle size have the characteristics of small size, large specific surface, low density, hollow structure, and good permeability. It has broad application prospects in the fields of sustained release, coatings, biology, chemical catalysis, cosmetics, lightweight fillers, etc. Polymer hollow materials with environmental responsiveness combine the unique structural characteristics of hollow materials and the excellent response properties of environmentally responsive materials, endowing materials with greater controllability and environmental responsive functionality, and have great potential value. [0003] Temperatu...

Claims

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Application Information

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IPC IPC(8): B01J13/06B01J13/14B01J13/00C08F292/00C08F220/54
CPCB01J13/0052B01J13/06B01J13/14C08F292/00C08F220/54
Inventor 胡静花琴张玉迪邓维钧王宇轩
Owner SHANGHAI INSTITUTE OF TECHNOLOGY
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