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Preparation method of double-gradient porous NiTi / hydroxyapatite composite

A technology of hydroxyapatite and composite materials, which is applied in the field of preparation of double gradient porous NiTi/hydroxyapatite composite materials, can solve the problems of reducing NiTi alloys and unfavorable Ni ions for human health, and achieves the protection of biocompatibility. Effect

Inactive Publication Date: 2017-01-04
LIAONING UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

NiTi alloy is currently the most widely used and most promising shape memory alloy in the field of medical clinical applications. It has good characteristics such as shape memory effect, superelastic effect, wear resistance and corrosion resistance, and biocompatibility. Material requirements, but it is easy to precipitate Ni ions that are harmful to human health after soaking in human body fluid for a long time, so it is necessary to reduce the content of NiTi alloy in implants

Method used

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  • Preparation method of double-gradient porous NiTi / hydroxyapatite composite
  • Preparation method of double-gradient porous NiTi / hydroxyapatite composite

Examples

Experimental program
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Effect test

example 1

[0022] 1. Preparation of NiTi / hydroxyapatite slurry

[0023] a. According to the number of parts by mass, put 20 parts of sodium stearate into 80 parts of absolute ethanol, then place the mixed solution in a constant temperature water bath at 60°C and stir to completely dissolve the sodium stearate, and prepare stearin with a concentration of 20%. Sodium bicarbonate-ethanol premix solution, and then keep warm in a constant temperature water bath at 60°C for later use.

[0024] b. In parts by mass, weigh 35.55 parts of hydroxyapatite with a particle size of 100 nm, 2.7 parts of NiTi with a particle size of 60 nm, 6.75 parts of polystyrene as a pore-forming agent with a particle size of 20 μm; 1.35 parts of polyethylene glycol as a dispersant, stearin 53.65 parts of sodium bicarbonate-ethanol premix, which was weighed and immediately placed in a constant temperature water bath at 60°C for future use.

[0025] c. Add 1.35 parts of dispersant polyethylene glycol to the 53.65 p...

example 2

[0030] 1. Preparation of NiTi / hydroxyapatite slurry

[0031] a. According to the number of parts by mass, put 20 parts of sodium stearate into 80 parts of absolute ethanol, then place the mixed solution in a constant temperature water bath at 70°C and stir to completely dissolve the sodium stearate, and prepare stearin with a concentration of 20%. Sodium acid-ethanol premixed solution, and then kept in a constant temperature water bath at 70°C for later use.

[0032] b. In parts by mass, weigh 47.4 parts of hydroxyapatite with a particle size of 100 nm, 3.6 parts of NiTi with a particle size of 60 nm, 9 parts of polystyrene as a pore-forming agent with a particle size of 20 μm; 3 parts of polyethylene glycol as a dispersant, stearin 37 parts of sodium bicarbonate-ethanol premixed solution, which was weighed and immediately placed in a constant temperature water bath at 70°C for future use.

[0033]c. Add 3 parts of dispersant polyethylene glycol to the 37 parts of sodium s...

example 3

[0038] 1. Preparation of NiTi / hydroxyapatite slurry

[0039] a. According to the number of parts by mass, put 20 parts of sodium stearate into 80 parts of absolute ethanol, then place the mixed solution in a constant temperature water bath at 65°C and stir to completely dissolve the sodium stearate, and prepare stearin with a concentration of 20%. Sodium acid-ethanol premixed solution, and then kept in a constant temperature water bath at 65°C for later use.

[0040] b. In parts by mass, weigh 39.5 parts of hydroxyapatite with a particle size of 100nm, 3 parts of NiTi with a particle size of 60nm, 7.5 parts of polystyrene as a pore-forming agent with a particle size of 20 μm; 2 parts of dispersant polyethylene glycol, stearic acid 48 parts of sodium-ethanol premixed solution, which was weighed and immediately placed in a constant temperature water bath at 65°C for future use.

[0041] c. Add 2 parts of dispersant polyethylene glycol to the 48 parts of sodium stearate-ethan...

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Abstract

The invention provides a preparation method of a double-gradient porous NiTi / hydroxyapatite composite. According to the preparation method, polystyrene, as a pore former, nanometer NiTi and hydroxyapatite are prepared into non-water-based complex-phase slurry; and then, the porous NiTi / hydroxyapatite composite with porosity and the NiTi content both in continuous gradient distribution is prepared through the centrifuging-gel casting technology. The end, having a high porosity and a high hydroxyapatite content, of the porous NiTi / hydroxyapatite composite has good biocompatibility and facilitates ingrowth of new bone tissue and conveyance of body fluids. The end, having a low porosity and a high NiTi content, of the porous NiTi / hydroxyapatite composite can significantly improve the strength and the tenacity of a hydroxyapatite base material because of the low porosity and the martensite phase transformation toughening of the nanometer NiTi particles.

Description

technical field [0001] The invention relates to a preparation method of a double-gradient porous NiTi / hydroxyapatite composite material. Background technique [0002] Hydroxyapatite (HA) is one of the main components of natural bones and teeth. Crystallized HA in adult bones accounts for about 45% of human bone mass. Synthetic HA is the same as adult bones The crystallized hydroxyapatite is basically the same in composition and form, has good biocompatibility and biological activity, is non-toxic to the living body, has no rejection reaction, does not induce cell cancer, and has certain degradability, etc. It has excellent biomaterial properties, and it can form a strong active link with living bones. In addition, when hydroxyapatite has a porous structure, it is also conducive to the transmission of body fluids and the ingrowth of bone tissue, so it is widely used clinically. With the development of the global aging trend, human hard tissue replacement materials will recei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F3/11B22F3/22B22F1/00A61L27/42A61L27/56
CPCA61L27/425A61L27/56B22F3/1109B22F3/1121B22F3/22A61L2430/02B22F2998/10B22F2999/00B22F1/107B22F2201/20B22F2207/01B22F2207/17B22F2202/17B22F2009/043
Inventor 李强魏磊山于景媛石萍
Owner LIAONING UNIVERSITY OF TECHNOLOGY
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