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Preparation technique of medicinal preparation for improving curative effects of removing heat to cool blood and relieving swelling and pain

A technology for reducing swelling and pain, and pharmaceutical preparations, which can be used in non-central analgesics, medical preparations containing active ingredients, antipyretics, etc., and can solve the problems of low extraction rate of traditional Chinese medicine, increased production cost, waste of raw materials of traditional Chinese medicine, etc. , to achieve the effect of improving quality and efficacy, saving resources and costs, and high extraction efficiency

Inactive Publication Date: 2016-12-14
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the current preparation process of this product is mainly through traditional extraction techniques such as direct high-temperature heating and decocting, filtration and standing, the preparation process is relatively simple and rough, which may easily lead to low extraction rate of traditional Chinese medicine, and heat-sensitive functional components of medicinal materials are easy to degrade when heated. Seriously affect the quality of the product and the curative effect of oral administration, and the raw materials of Chinese medicinal materials are seriously wasted, which increases the production cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prescription composition: puffball 703kg, yam yam 703kg, oyster (calcined) 703kg, mountain bean root 424kg, starch 30kg, made into 1,000,000 capsules (0.3g / capsule).

[0019] The following steps are used to prepare: 70.3kg of yam and 70.3kg of oyster (calcined) are respectively crushed into fine powder with a particle size of 18 microns by ultrafine grinding technology; Except for the fine powder, add the rest of the medicinal materials into water with 8 times the weight of the medicinal materials and ultrasonically extract twice, each time for 1.5h (ultrasonic power 65kw, temperature 25°C), filter, and the filtrate stands at 4°C for 12h. Filter through a filter membrane and collect the filtrate; the filtrate is concentrated under reduced pressure to a thick paste with a relative density of 1.38 at 50°C; add 70.3kg of yam and 70.3kg of oyster (calcined) fine powder, mix well, dry, and pulverize , add 30kg of starch, granulate, dry, and fill the capsules to obtain swelli...

Embodiment 2

[0030] Prescription composition: puffball 351.5kg, yam 351.5kg, oyster (calcined) 351.5kg, mountain bean root 212kg, starch 18kg, a total of 500000 capsules (0.3g / capsule) were made.

[0031] The following steps are used to prepare: 35.15kg of yam and 35.15kg of oysters (calcined) are respectively crushed into fine powders with a particle size of 5 microns by ultra-fine grinding technology; Except for the fine powder, add the rest of the medicinal materials into water 8 times the weight of the medicinal materials and ultrasonically extract twice, each time for 0.75h (ultrasonic power 40kw, temperature 25°C), filter, and the filtrate stands at 4°C for 12h. Filter through a filter membrane to collect the filtrate; the filtrate is concentrated under reduced pressure to a thick paste with a relative density of 1.40 at 50°C; add 35.15kg of yam and 35.15kg of oyster (calcined) fine powder, mix well, dry, and pulverize , adding 18kg of starch, granulating, drying, and filling capsule...

Embodiment 3

[0033] Prescription composition: puffball 1406kg, yam yam 1406kg, oyster (calcined) 1406kg, mountain bean root 848kg, dextrin 65kg, a total of 2,000,000 capsules (0.3g / capsule) were made.

[0034] The following steps are used to prepare: 140.6kg of yam and 140.6kg of oyster (calcined) are respectively crushed into fine powder with a particle size of 30 microns by ultrafine grinding technology; Except for the fine powder, add the rest of the medicinal materials into water with 8 times the weight of the medicinal materials and ultrasonically extract twice, each time for 2 hours (ultrasonic power 80kw, temperature 25°C), filter, and the filtrate stands at 4°C for 12h, and ultrafiltration with a molecular weight cut-off of 2000 Membrane filtration to collect the filtrate; the filtrate is concentrated under reduced pressure to a thick paste with a relative density of 1.35 at 50°C; add 140.6kg of yam and 140.6kg of oyster (calcined) fine powder, mix well, dry, and pulverize. Add 65k...

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Abstract

A preparation technique of a medicinal preparation for improving curative effects of removing heat to cool blood and relieving swelling and pain relates to the technical field of Chinese herbal preparation extraction and preparation. The medicinal preparation takes puffball, Dioscorea cirrhosa Lour., concha ostreae (calcined), subprostrate sophora and the like as raw materials, and after the adoption of modern extraction techniques including superfine grinding, ultrasonic wave extraction, membrane filtration and the like, the Chinese herb extracts are mixed with auxiliary materials to prepare capsules. The preparation technique provided by the invention has the following beneficial effects: the combination of superfine grinding and ultrasonic extraction is adopted, the extraction efficiency is high, the full use of medicinal materials is facilitated, heat-sensitive component degradation is avoided, drug quality and efficacy are improved, and Chinese medicinal materials are saved and the production cost is reduced.

Description

technical field [0001] The invention relates to the technical field of extraction and preparation of traditional Chinese medicines, in particular to a preparation process of a medicinal preparation for improving the curative effects of clearing away heat and cooling blood, reducing swelling and relieving pain. Background technique [0002] The anti-tumor hemorrhoid capsule, which is composed of Chinese medicinal materials such as puffball, yam, oyster (calcined), and mountain bean root, has the powerful effects of clearing away heat and cooling blood, reducing swelling and relieving pain, and is used for internal hemorrhoid bleeding, external hemorrhoid swelling and pain, etc. treat. However, since the current preparation process of this product is mainly through traditional extraction techniques such as direct high-temperature heating and decocting, filtration and standing, the preparation process is relatively simple and rough, which may easily lead to low extraction rate ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/48A61P29/00A61P9/14A61K35/618
CPCA61K36/8945A61K9/1652A61K35/618A61K36/07A61K36/489A61K2236/15A61K2236/331A61K2236/53A61K2300/00
Inventor 陈梁吴永忠张荷英郭锋刘辉辉邹裕宏高小明
Owner JIANGXI POZIN PHARMA
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