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Degradable meninx repairing material and preparing method thereof

A technology for repairing materials and meninges, which is applied in the field of natural biomedical materials, can solve the problems that the product cannot be degraded in the body, avoid side effects such as immune rejection or inflammation, prevent cerebrospinal fluid leakage, and facilitate removal

Inactive Publication Date: 2016-12-07
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of BC in dura mater repair is currently the only one in the market. Dura Repair, and the product does not degrade in vivo

Method used

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  • Degradable meninx repairing material and preparing method thereof
  • Degradable meninx repairing material and preparing method thereof
  • Degradable meninx repairing material and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1, preparation of degradable meningeal repair material

[0080] 1. Spread paraffin particles with a particle size of 100 μm on the lower layer of the culture container, and the spreading thickness is 1 mm, to prepare a scaffold layer for inducing tissue regeneration (thickness is 1 mm, pore diameter is 100 μm); the upper layer spreads 100 nm porogen paraffin (thickness 1mm, pore size 100nm), used to prepare the anti-adhesion layer. Insert the activated Acetobacter xylinum into the bacterial culture solution and mix it evenly, then add it into the culture container, the depth of the culture medium is about 2mm, and culture it at 20°C for 20 days, take out the BC membrane and place it at 50-70°C Heat in a water bath to remove the porogen paraffin. The bacterial culture solution is: mannitol 25g / L, tryptone 3g / L, yeast powder 5g / L, pH 5.0, sterilized at 121°C for 20min, cooled to 30°C before use.

[0081] 2. After the above-mentioned BC membrane was fully wash...

Embodiment 2

[0085] Embodiment 2, preparation of degradable meningeal repair material

[0086] 1. CaCO with particle size of 500 μm and 500 nm 3 Spread on the lower layer and upper layer of the culture container, respectively as the scaffold layer and anti-adhesion layer for inducing tissue regeneration, and the spreading thickness is 1.5mm. Insert the activated Acetobacter xylinum into the bacterial culture solution, mix it evenly, add it to the culture container, and culture it at 30°C for 14 days, then take out the BC membrane and soak it in 2% hydrochloric acid solution for 5 hours to remove the CaCO 3 porogen. The bacterial culture solution is: mannitol 25g / L, tryptone 3g / L, yeast powder 5g / L, pH 5.0, sterilized at 121°C for 20min, cooled to 30°C before use.

[0087] 2. The above BC membrane was fully washed with distilled water and dried by centrifugation, and then soaked in 8mol / L NaOH solution at 25°C and 6% Tween-40 solution at 30°C for 5h and 40h respectively. After immersion,...

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Abstract

The invention discloses a degradable meninx repairing material and a preparing method thereof. The degradable meninx repairing material is prepared from a bacterial cellulose film with gaps, and the bacterial cellulose film is oxidized bacterial cellulose with C6-site hydroxyl oxidized into carboxyl. The preparing method of the degradable meninx repairing material includes the following steps that 1, the gaps are formed in the bacterial cellulose film, and the bacterial cellulose film with the gaps are obtained; 2, a group oxidizing reaction is carried out on the bacterial cellulose film with the gaps obtained in the first step, and the degradable meninx repairing material can be obtained. The meninx repairing material has the synechia preventing function and the cerebrospinal fluid leakage preventing function, and can be gradually degraded while guiding auto-defect repairing of cerebral dura mater tissue.

Description

technical field [0001] The invention relates to a degradable meningeal repair material and a preparation method thereof, belonging to the field of natural biomedical materials. Background technique [0002] The dura mater is a thick and tough double-layer membrane with a smooth inner layer and a rough outer layer, which has the function of protecting the brain and preventing the cerebrospinal fluid from communicating with the outside world. Open craniocerebral injury, inflammation, brain swelling, brain tumor invasion, excessive electrocautery and other factors can lead to meningeal defect, leading to brain dysfunction, brain tissue adhesion, epilepsy and other seizures. The use of dura mater repair materials plays an important role in the reconstruction and repair of dura mater. [0003] Although there are many types of dura mater substitute materials at home and abroad, there are still many problems. Allogeneic human dura mater, fascia lata, acellular human dermis and ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/56A61L27/20A61L27/36
CPCA61L27/58A61L27/20A61L27/3637A61L27/56C08L1/02
Inventor 郭刚周颖孙先昌
Owner YANTAI ZHENGHAI BIO TECH
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