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Radix paeoniae alba particles and traditional Chinese medicine preparation

A white peony root and granule technology, applied in the directions of non-central analgesics, antipyretics, anti-inflammatory agents, etc., can solve the problems of quality restriction, physical injury of inspectors, consumption of large reagents, etc., to achieve quality control and shorten testing. time, the effect of reducing workload

Active Publication Date: 2016-11-09
GUANGDONG YIFANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of water and ethanol extracts in Baishao granules requires several hours with reference to the pharmacopoeia, and the operation is more complicated.
The main chemical component of Baishao Granules is paeoniflorin. As a quality control index, the traditional method uses high-performance liquid chromatography, etc., which often requires complicated pretreatment of samples, consumes a lot of reagents, and pollutes the environment and inspectors. The body is damaged, and the information feedback is lagging behind, which cannot meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

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  • Radix paeoniae alba particles and traditional Chinese medicine preparation
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  • Radix paeoniae alba particles and traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of Radix Paeoniae Alba Granules: Take decoction pieces of Radix Paeoniae Alba, add water to decoct twice, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; Paste, filter with 350-mesh sieve while it is hot; spray under the conditions of air inlet temperature 150-190°C, material pump speed 400-700 rpm, outlet air temperature 80-95°C, and air delivery temperature 35-45°C Drying, spraying dry powder; dry granulation under the conditions of punching plate aperture 1.50mm, roller motor frequency 40-50HZ, feeding motor frequency 30-50HZ, oil cylinder pressure 16-24bar, to obtain white peony granules with a particle size of 16-40 mesh.

Embodiment 2

[0038] The preparation of the traditional Chinese medicine preparation containing the Radix Paeoniae Alba granules: Take Radix Paeoniae Alba, add water to decoct twice, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; combine the medicinal liquids, and concentrate the filtrate to a relative density of 1.08 (80 ℃), filter it with a 350-mesh sieve while it is hot; when the air inlet temperature is 150-190°C, the material pump speed is 400-700 rpm, the outlet air temperature is 80-95°C, and the air supply temperature is 35-45°C Spray drying under the same conditions to obtain dry powder; dry granulation under the conditions of punching plate aperture 1.50mm, roller motor frequency 40-50HZ, feeding motor frequency 30-50HZ, oil cylinder pressure 16-24bar, and the particle size is 16-40 mesh. Paeoniae Alba Granules. Mix 100g of Radix Paeoniae Alba granules with 65g of maltodextrin, add appropriate amount of magnesium stearate, mix well, and press i...

Embodiment 3

[0040] A method for rapidly detecting the moisture content of Radix Paeoniae Alba granules based on near-infrared spectroscopy, specifically comprising the following steps:

[0041] a. Take white peony granule samples, a total of 106 batches, about 3g each, grind into fine powder, put it into a stoppered glass sample bottle, place it on a near-infrared scanner for scanning, collect spectra, scanning conditions: scanning range 4000-12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum of 106 batches of Radix Paeoniae Alba granules shown;

[0042] At the same time, according to the standard method specified in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was measured by the drying method. About 2 g of Radix Paeoniae Alba granules that were ground into fine ...

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Abstract

The invention discloses radix paeoniae alba particles. The radix paeoniae alba particles are prepared through a method including the following steps that radix paeoniae alba medicinal slices are taken, water is added into the medicinal slices to decoct the medicinal slices for 1-3 times, water with the volume being 5-10 times that of the medicinal slices is added each time, and heating decocting is carried out for 1-2 h each time; the decoction is collected, the filter liquor is concentrated to obtain clear paste with the relative density of 1.02-1.12, and the clear paste is filtered through a 250-350-mesh screen while the clear paste is hot; spray drying is carried out on the clear paste to obtain spray powder; dry granulation is carried out on the spray powder to obtain the radix paeoniae alba particles with the particle size of 16-40 mesh. The preparation process of the radix paeoniae alba particles is simple, process parameters are easy to control, and a detection method is scientific, fast and high in operability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to white peony granules and traditional Chinese medicine preparations. Background technique [0002] Paeoniae Alba is the dry root of Paeonia lactiflora Pall., a plant of the ranunculaceae family. It is bitter, sour, slightly cold, and returns to the liver and spleen meridian. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of decoction pieces replaces the decoction pieces of traditional Chinese medicine for clinical syndrome differentiation and treatment, addition and subtraction according to the syndrome, and formula use. Compared with the traditional Chinese medicine decoction method of "medicine in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61K9/16G01N21/359A61P29/00A61P1/16A61P1/14A61P15/00A61K125/00
CPCA61K9/1605A61K36/65A61K36/71A61K2236/331A61K2236/39A61K2236/51G01N21/359
Inventor 朱德全刘丽萍王闽予林振东陈向东谭登平程学仁
Owner GUANGDONG YIFANG PHARMA
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