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Water-soluble povidone iodine powder preparation and preparation method thereof

A povidone-iodine and water-soluble technology, which is applied in the field of water-soluble povidone-iodine powder preparation and its preparation, can solve the problems affecting the effect, and achieve the effects of ensuring water solubility, avoiding residue and good stability

Inactive Publication Date: 2016-10-26
贝嘉美(天津)生物技术研发股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing povidone-iodine solution disinfectant will affect the effect if it is left for a long time, and it is analyzed that it is caused by degradation. At the same time, the quality control of povidone-iodine in the production process and the water solubility of the powder preparation are all problems to be solved in the prior art. Yes, in order to overcome the defects of the prior art, the present invention provides a povidone-iodine powder with good stability, good sterilization effect, high quality, water-soluble and long-term storage without affecting the effect

Method used

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  • Water-soluble povidone iodine powder preparation and preparation method thereof
  • Water-soluble povidone iodine powder preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Detect that the humidity of the purchased povidone K30 is 2.1%, weigh 100g, put it into a closed evaporator, add 3.9g of water, after high temperature gasification, the humidity of povidone K30 reaches 5%, weigh 25g of refined iodine and mix it Uniformly, put into the airtight evaporator, then steam heating 80 °, complexation for 40 hours, to room temperature, discharging to obtain povidone iodine, the available iodine weight percentage of the povidone iodine is greater than or equal to 14.0%, Detect its aldehyde < 50ppm, peroxide < 50ppm, sulfate ash < 0.02%.

Embodiment 2 9

[0019] Disperse 200 g of povidone-iodine obtained in Example 1 with 10 times the mass of water, then add 10 g of antioxidant and 10 g of pH stabilizer, then stir at room temperature for 20 minutes, add 12 g of potassium iodide, 15 g of potassium iodate, and 5 g of glycerin, Stir evenly to obtain a povidone-iodine aqueous solution; put the obtained aqueous solution into a lyophilizer to freeze-dry to obtain povidone-iodine powder, pass through a 200-mesh sieve to obtain a finished povidone powder preparation.

[0020] With reference to the weight of each component in Table 1, the operation steps are the same as above to obtain Embodiments three to ten,

[0021] The quality of each component in the embodiment two~nine of table 1

[0022]

Povidone iodine

potassium iodide

potassium iodate

glycerin

L-Ascorbic Acid

Potassium dihydrogen phosphate

Embodiment two

200

12

15

5

10

10

Embodiment Three

220

15

20

7...

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Abstract

A water-soluble povidone-iodine powder preparation, characterized in that it comprises the following parts by weight: 200-300 parts of povidone-iodine, 10-15 parts of potassium iodide, 10-20 parts of potassium iodate, and 5-10 parts of glycerin parts, 10-15 parts of antioxidant, 10-20 parts of pH stabilizer; the available iodine weight percentage content of the povidone-iodine is greater than or equal to 14.0%, the antioxidant is a water-soluble antioxidant, and the pH stabilizer It is potassium dihydrogen phosphate; the particle size of the powder preparation is greater than 200 mesh. The preparation method comprises the steps of dissolving the above-mentioned components in water and stirring uniformly to obtain a povidone-iodine aqueous solution; adding it to a freeze dryer to freeze-dry to obtain povidone-iodine powder, and passing through a 200-mesh sieve to obtain a finished povidone-iodine powder preparation. The homemade povidone iodine is used as raw material, mixed with auxiliary materials and then freeze-dried to obtain a powder preparation. Water is used as a solvent to avoid the residue of organic solvents, and at the same time ensure the water solubility of the prepared powder preparation; the freeze-drying process ensures the powder preparation stability.

Description

technical field [0001] The invention relates to a disinfectant powder, in particular to a water-soluble povidone-iodine powder preparation and a preparation method thereof. Background technique [0002] Povidone-iodine (Polyvinyl pyrrolidone-Iodine, PVP-I), also known as povidone iodine, is a new type of iodine-containing sterilizing preparation. PVP-I is a complex formed by polyvinylpyrrolidone (PVP) and iodine, containing 9-12% of available iodine. PVP is a polyethylene non-ionic surfactant with a molecular weight of 10,000-40,000 Da. It has a solubilizing effect and is often used as a drug carrier. PVP is stable in nature and generally does not cause incompatibility with other drugs. After forming a complex with iodine, the iodine element is combined with the inner side of the PVP helical structure, greatly improving the solubility of iodine. At the same time, the product gradually decomposes and the iodine element is released slowly. Play the role of continuous disinfe...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/79A61K31/04A61P17/00
CPCA61K9/19A61K9/0014A61K31/79
Inventor 苏永鹏
Owner 贝嘉美(天津)生物技术研发股份有限公司
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