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Absorbable fundal mesh composite and preparation method thereof

A composite material and patch technology, applied in the field of materials, can solve the problems of rejection, mucosal wear, infection, and low infection rate, and achieve good mechanical properties and good biocompatibility

Inactive Publication Date: 2016-10-12
李世荣 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, autologous tissue used as a reconstruction material has the advantages of no mucosal abrasion, no risk of disease transmission, and a very low infection rate, but there may be complications related to fascia harvesting, such as harvesting trauma of the lower extremity or abdomen
Synthetic materials are stable, strong, and easy to apply, but there may be complications such as infection, rejection, and mucosal abrasion.

Method used

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  • Absorbable fundal mesh composite and preparation method thereof
  • Absorbable fundal mesh composite and preparation method thereof
  • Absorbable fundal mesh composite and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] The absorbable uterine fundus patch composite material is composed of a biofilm matrix and a coating, and the coating is evenly distributed on the surface of the biofilm matrix; the biofilm matrix is ​​composed of pig pericardium after degreasing and decellularization; the The coating is composed of a biodegradable high molecular polymer; the biofilm matrix is ​​chemically cross-linked with a bridging agent. The preparation method of the absorbable uterine fundus patch composite material comprises the following steps:

[0039] 1) Take the biofilm: mechanically separate the heart of the pig or cow from the pericardium, scrape off the fat on the pericardium, and rinse the pericardium repeatedly until the nearly transparent pericardium is ready for use;

[0040] 2) Degreasing: Soak the obtained porcine pericardium in a mixture of methanol and chloroform with a volume ratio of 1:1 for degreasing for 12 hours, rinse with deionized water for 3 times, for a total of 24 hours; ...

Embodiment 2

[0046]The absorbable uterine fundus patch composite material is composed of a biofilm matrix and a coating, and the coating is evenly distributed on the surface of the biofilm matrix; the biofilm matrix is ​​composed of pig small intestinal submucosa after degreasing and decellularization; The coating is composed of a biodegradable high molecular polymer; the biofilm matrix is ​​chemically cross-linked with a bridging agent. The preparation method of the absorbable uterine fundus patch composite material comprises the following steps:

[0047] 1) Take the biofilm: mechanically remove the serosa layer, serosa layer, and muscular layer of the pig small intestine to obtain the submucosa of the small intestine, and wash it repeatedly for later use;

[0048] 2) Degreasing: Soak the obtained porcine small intestinal submucosa in a mixed solution of methanol and chloroform with a volume ratio of 1:1 for 12 hours, and rinse with deionized water for 3 times;

[0049] 3) Decellularizat...

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Abstract

The invention discloses an absorbable uterine fundus patch composite material and a preparation method thereof. The composite material is composed of a biofilm matrix and a coating, and the coating is evenly distributed on the surface of the biofilm matrix; the biofilm matrix is ​​composed of The natural biofilm is formed after degreasing and decellularization; the coating is composed of a biodegradable high molecular polymer; and the biofilm matrix is ​​also subjected to cross-linking treatment. The invention adopts the biofilm matrix as the matrix material, and the biofilm matrix is ​​cross-linked, and the coating adopts biodegradable high molecular polymers, and the obtained palace fundus patch composite material not only has good mechanical properties, but also has It has good biocompatibility and can be absorbed and degraded by organisms, providing a new composite material for pelvic organ prolapse surgery.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to an absorbable uterine fundus patch composite material and a preparation method thereof. Background technique [0002] Pelvic organ prolapse and stress urinary incontinence are common diseases that seriously affect the quality of life of middle-aged and elderly women. With the improvement of living standards, people pay more and more attention to such diseases, so pelvic floor reconstruction surgery has become a new discipline. The conventional surgical methods for the treatment of pelvic organ prolapse are vaginal hysterectomy and vaginal anterior and posterior wall repair, but the postoperative recurrence rate and reoperation rate of this treatment are both over 30%. In order to reduce the recurrence rate of surgery, researchers in this field have conducted in-depth discussions, including the application of mesh. [0003] According to the characteristics of pelvic floor ti...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61F2/00
CPCA61L27/34A61F2/005A61L2300/602A61L2300/604A61L2420/04C08L67/04
Inventor 王秋玉李世荣李晓格
Owner 李世荣
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