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Liriope platyphylla Wang et Tang extract with anti-aging activity and preparation method and application thereof

A technology of Ophiopogon japonicus and its extract, which is applied in the field of Ophiopogon japonicus broad-leaved extract and its preparation, can solve problems such as not found in the search, and achieve the effects of reducing fine lines, improving stability, and high content of effective substances

Inactive Publication Date: 2016-10-12
曹蕊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The research on Ophiopogon japonicus in my country mainly focuses on horticulture, breeding and active ingredient research, etc. There is currently no corresponding record of the research or patent application of Ophiopogon japonicus broad-leaved in cosmetics

Method used

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  • Liriope platyphylla Wang et Tang extract with anti-aging activity and preparation method and application thereof
  • Liriope platyphylla Wang et Tang extract with anti-aging activity and preparation method and application thereof
  • Liriope platyphylla Wang et Tang extract with anti-aging activity and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of Ophiopogon japonicus extract with anti-aging activity:

[0028] Add 1 part of tocopherol to 70 parts of ethanol, dissolve for later use. Add 1 kg of dried Ophiopogon japonicus tuber root powder to 2 times 50% ethanol containing tocopherol for percolation extraction three times, filter, and collect the filtrate; place the filtrate in a centrifuge, centrifuge at 3000r / min for 20 minutes, discard Remove the precipitate, collect the supernatant, and set aside; evaporate and concentrate the supernatant obtained by centrifugation under reduced pressure to a density of 1.05-1.10 (50°C); purify the concentrated solution on an MCI resin column, and wash it with 2 column volumes of purified water to remove impurities , 2 column volumes of 40% (volume fraction) ethanol for impurity removal, and 2 column volumes of 70% (volume fraction) ethanol active ingredient eluate. Add 10 g of activated carbon to the eluate for decolorization, filter, concentrate and d...

Embodiment 2

[0030] A preparation method of Ophiopogon japonicus extract with anti-aging activity:

[0031] Add 1 part of tocopherol to 80 parts of ethanol, dissolve for later use. Add 1 kg of dried Ophiopogon japonicus tuber root powder to 3 times 70% ethanol containing tocopherol for percolation extraction three times, filter, and collect the filtrate; place the filtrate in a centrifuge, centrifuge at 4000r / min for 30 minutes, discard Remove the precipitate, collect the supernatant, and set aside; the supernatant obtained by centrifugation is evaporated under reduced pressure and concentrated to a density of 1.05-1.10 (50°C); the concentrated solution is purified on an MCI resin column, and washed with 10 column volumes of purified water to remove impurities 10 column volumes of 50% (volume fraction) ethanol for impurity removal, and 10 column volumes of 80% (volume fraction) ethanol active ingredient eluate. Add 70 g of activated carbon to the eluent for decolorization, filter, concent...

Embodiment 3

[0033] A preparation method of Ophiopogon japonicus extract with anti-aging activity:

[0034] Add 1 part of tocopherol to 75 parts of ethanol, dissolve for later use. Add 1 kg of dried Ophiopogon japonicus tuber root powder to 2.5 times 65% ethanol containing tocopherol for percolation extraction three times, filter, and collect the filtrate; place the filtrate in a centrifuge, centrifuge at 3500r / min for 25 minutes, discard Remove the precipitate, collect the supernatant, and set aside; the supernatant obtained by centrifugation is evaporated under reduced pressure and concentrated to a density of 1.05-1.10 (50°C); the concentrated solution is purified on an MCI resin column, and washed with 5 column volumes of purified water to remove impurities , 5 column volumes of 45% (volume fraction) ethanol for impurity removal, and 5 column volumes of 75% (volume fraction) ethanol active ingredient eluate. Add 50 g of activated carbon to the eluent for decolorization, filter, concen...

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Abstract

The invention discloses an extract of Ophiopogon japonicus with anti-aging activity and its preparation method and application, comprising the following steps: 1) Adding dried Ophiopogon japonicus root powder into an extraction solvent containing tocopherol, Extract by percolation, filter, and collect the filtrate; 2) Centrifuge the filtrate to remove the precipitate, discard the precipitate, collect the supernatant, and set aside; 3) Concentrate the supernatant obtained by centrifugation under reduced pressure to obtain a concentrate; 4) Step 3) The concentrated solution is purified on an MCI resin column, washed with water to remove impurities, 30-50% (volume fraction) ethanol to remove impurities, 60-85% (volume fraction) ethanol to elute, and collect the eluate; 5) Step 4 ) The eluent is decolorized by adding active carbon, filtered, concentrated, and dried to obtain the refined Ophiopogon japonicus extract. The Ophiopogon japonicus extract obtained by the preparation method of the invention has high content of effective substances and stable performance, and can be added to various skin care products to achieve anti-aging effects.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to an extract of Ophiopogon japonicus with anti-aging activity and its preparation method and application. Background technique [0002] With the development of the beauty and cosmetics industry, natural plant products are welcomed due to their advantages such as safe use, mild effect, and obvious effect. Generally, plant extracts containing active ingredients are obtained through corresponding processing and added to cosmetics. [0003] The medicinal material of Ophiopogon japonicus is the dry tuber root of Ophiopogon japonicus broad-leaved plant of the genus Ophiopogon japonicus in the family Liliaceae. It is also known as "Big Ophiopogon japonicus" among the people. It has been used as a substitute for authentic medicinal materials Ophiopogon japonicus and Ophiopogon japonicus in many areas of my country. , Treatment of febrile disease injury body fluid, upset and thirst embolism. Studi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/67A61Q19/08
CPCA61K8/97A61K8/678A61K2800/522A61K2800/805A61Q19/08
Inventor 曹蕊
Owner 曹蕊
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