Magnesium chlorogenate medicinal composition, its preparing method and use

A technology of magnesium chlorogenic acid and composition, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of complex preparation process, low bioavailability, slow onset of drug effect, etc., and achieve good process reproducibility , quality controllable, good antibacterial and anti-inflammatory effects

Inactive Publication Date: 2006-08-09
广东仁泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally used in compound preparations, the unilateral use is mainly oral, its drug effect is slow, the bioavailability is low, and the preparation process is relatively complicated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of magnesium chlorogenic acid pharmaceutical composition

[0016] Take 6kg honeysuckle and grind it into a coarse powder, add 54L deionized water and heat to 80°C, warm soak for 2 hours, turn it every 15 minutes, and release the first extract; add 54L deionized water to the dregs and heat to 80°C , warm soaking and extracting for 2 hours, turning it every half hour to get the second extract. Combine the two extracts and concentrate to 3g crude drug / ml (2000ml), add 95% medicinal ethanol to adjust the ethanol concentration to 80%, add 20% ammonia water to adjust the pH value to 8, stir well, and put it in a refrigerator for 24 hours. The refrigerated liquid is filtered, and the continued filtrate reclaims ethanol, and continues to concentrate under reduced pressure to 4g crude drug / ml (1500ml), adds 7500ml deionized water under sufficient stirring, adds 20% ammonia water and adjusts the pH value to 9-10 (measured value 9.9), puts Let stand ...

Embodiment 2

[0017] Embodiment 2: the preparation of magnesium chlorogenic acid composition

[0018] Take 6kg of honeysuckle and grind it into coarse powder, add 60L of deionized water and heat to 80°C, warm soak for 2 hours, turn it every 15 minutes, and release the first extract; add 60L of deionized water to the dregs and heat to 80°C , warm soaking and extracting for 2 hours, turning it every half hour to get the second extract. Combine the two extracts and concentrate to 3g crude drug / ml (2000ml), add 95% medicinal ethanol to adjust the ethanol concentration to 80%, add 20% ammonia water to adjust the pH value to 8, stir well, and put it in a refrigerator for 24 hours. The refrigerated liquid is filtered, and the continued filtrate reclaims ethanol, and continues to concentrate under reduced pressure to 4g crude drug / ml (1500ml), adds 7500ml deionized water under sufficient stirring, adds 20% ammonia water and adjusts the pH value to 9-10 (measured value 9.2), puts Let stand overnigh...

Embodiment 3

[0019] Embodiment 3: the preparation of magnesium chlorogenic acid pharmaceutical composition

[0020] Take 6kg of honeysuckle and grind it into coarse powder, add 66L of deionized water and heat to 80°C, warm soak for 2 hours, turn it every 15 minutes, and release the first extract; add 66L of deionized water to the dregs and heat to 80°C , warm soaking and extracting for 2 hours, turning it every half hour to get the second extract. Combine the two extracts and concentrate to 3g crude drug / ml (2000ml), add 95% medicinal ethanol to adjust the ethanol concentration to 80%, add 20% ammonia water to adjust the pH value to 8, stir well, and put it in a refrigerator for 24 hours. The refrigerated liquid is filtered, and the continued filtrate reclaims ethanol, and continues to concentrate under reduced pressure to 4g crude drug / ml (1500ml), adds 7500ml deionized water under sufficient stirring, adds 20% ammonia water and adjusts the pH value to 9-10 (measured value 9.5), puts Let...

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PUM

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Abstract

The present invention relates to a magnesium chlorogenate medicine composition. It contains magnesium chlorogenate, magnesium isochlorogenate and chlorogenic acid, in which the content of magnesium chlorogenate is above 90%. Said medicine composition can be used for curing angiocardiopathy and cerebrovascular disease. Besides, said invention also provides its preparation method.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition of magnesium chlorogenic acid, a preparation method and application thereof. Background technique: [0002] Chlorogenic acid is an active ingredient of traditional Chinese medicine honeysuckle, and its content is relatively high. Clinically, honeysuckle preparations are mainly used for antibacterial and anti-inflammatory. It is generally used in compound preparations, and the unilateral use is mainly oral. Its drug effect is slow, its bioavailability is low, and its preparation process is relatively complicated. The further development of new preparations from the classic medicinal material honeysuckle and the exploration of the medical use of the new preparations from honeysuckle are of great significance for the comprehensive and effective use of the treasure house of traditional Chinese medicine and the development of new drugs. Contents of the invention [0003] The object of the present inv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/215A61K36/35A61P9/00
Inventor 王伟刘二伟
Owner 广东仁泰药业有限公司
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