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Method for preparing L-tetrahydropalmatine hydrochloride from Stephania kwangsiensis

A technology of tetrahydropalmatine hydrochloride and ground tolerance, applied in the field of biomedicine preparation, can solve the problems of consumption of large acid and alkali solution, severe environmental pollution, etc., and achieve easy removal of impurities, reduction of pollution, high quality Effect

Active Publication Date: 2016-09-21
NANNING GODSEND BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention provides a method for preparing L-tetrahydropalmatine hydrochloride in Guangxi to solve the problem that the traditional extraction of L-tetrahydropalmatine uses acid extraction and alkali precipitation, then extraction with organic solvents, and finally crystallization treatment. It needs to consume a large amount of acid and alkali solution, and the environmental pollution is serious.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A method for preparing L-tetrahydropalmatine hydrochloride from Guangxi Dirong comprises the following steps:

[0027] S1: Crush 100kg of Guangxi Dirong medicinal materials to 40 meshes, put them into a percolation container, add 2% dilute hydrochloric acid with a volume of 500L and soak for 28 hours, then start to release percolation liquid at a flow rate of 100L / hour, collect percolation liquid, and collect During the percolation process, new dilute hydrochloric acid needs to be continuously added until the collected percolation solution reacts with the silicotungstic acid reagent and does not show the characteristics of alkaloid reaction.

[0028] S2: Pass the percolation solution obtained in step S1 through an ultrafiltration separation membrane with a molecular weight of 1000 Daltons to obtain a permeate, then pass through a reverse osmosis membrane with a molecular weight of 150 Daltons to obtain a reverse osmosis concentrate, and add 500L of deionized water Conce...

Embodiment 2

[0033] A method for preparing L-tetrahydropalmatine hydrochloride from Guangxi Dirong comprises the following steps:

[0034] S1: Crush 100kg of Guangxi Dirong medicinal materials to 30 meshes, put them into a percolation container, add 2% dilute hydrochloric acid with a volume of 500L and soak for 20 hours, then start to release percolation liquid at a flow rate of 100L / hour, collect percolation liquid, and collect During the percolation process, new dilute hydrochloric acid needs to be continuously added until the collected percolation solution reacts with the silicotungstic acid reagent and does not show the characteristics of alkaloid reaction.

[0035] S2: Pass the percolation solution obtained in step S1 through an ultrafiltration separation membrane with a molecular weight of 1000 Daltons to obtain a permeate, then pass through a reverse osmosis membrane with a molecular weight of 150 Daltons to obtain a reverse osmosis concentrate, and add 500L of deionized water Conce...

Embodiment 3

[0040] A method for preparing L-tetrahydropalmatine hydrochloride from Guangxi Dirong comprises the following steps:

[0041] S1: Crush 200kg of Guangxi Dirong medicinal materials to 10 meshes, put them into a percolation container, add 2% dilute hydrochloric acid with a volume of 500L and soak for 24 hours, then start to release percolation liquid at a flow rate of 200L / hour, collect percolation liquid, and collect During the percolation process, new dilute hydrochloric acid needs to be continuously added until the collected percolation solution reacts with the silicotungstic acid reagent and does not show the characteristics of alkaloid reaction.

[0042] S2: Pass the percolation solution obtained in step S1 through an ultrafiltration separation membrane with a molecular weight of 1000 Daltons to obtain a permeate, then pass through a reverse osmosis membrane with a molecular weight of 150 Daltons to obtain a reverse osmosis concentrate, and add 1000L deionized water Concent...

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Abstract

The invention discloses a method for preparing L-tetrahydropalmatine hydrochloride from Stephania kwangsiensis and belongs to the field of biomedicine. The method comprises the steps of extracting, separating, purifying, crystallizing and the like. Ultrafiltration and reverse osmosis membrane separation techniques are used in the method, mass acid is reused, and environmental pollution is reduced; through a membrane molecular weight of selective separation, impurities are easy to remove, and it is easier to prepare high-quality L-tetrahydropalmatine hydrochloride.

Description

【Technical field】 [0001] The invention belongs to the technical field of biomedicine preparation, and in particular relates to a method for preparing L-tetrahydropalmatine hydrochloride from Guangxi. 【Background technique】 [0002] Guangxi Dirong (scientific name: Stephania kwangsiensis) is a plant of the genus Stephaniaceae, which is endemic to China. According to the existing research results, it has been shown that the alkaloid components in Guangxi Dicong contain kebanine, dehydrokebanine, oxocarbanine, tetrahydropalmatine, palmatine, 1-corydalis monophenolic alkaloids, and isoscurin Active ingredients such as lycine, d-stiphenine, homoamoreline, tetrandrine, stephenine, qingfengjing, fangchinoline and so on. Tetrahydropalmatine (Tetrahydropalmatine) is a highly active alkaloid. Modern pharmacological studies have shown that it can inhibit the nerve center, and has analgesic, sedative, hypnotic, and tranquilizing effects; powerful. Its hypnotic effect occurs 15 minute...

Claims

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Application Information

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IPC IPC(8): C07D455/03
CPCC07D455/03
Inventor 唐桂英阮俊
Owner NANNING GODSEND BIOTECH
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