Single-dosage package arenobufagin and preparation method thereof

Abstract

The invention discloses single-dosage package arenobufagin. The single-dosage package arenobufagin is characterized in that white slurry of ear-side glands and dermal gland of bufo bufo gargarigans or bufo melanostictus is taken to be screened to remove impurities and to be dried at low temperature, and smashing is conducted to obtain arenobufagin powder. Single-dosage package is conducted according to the adult single dosage of the total amount, being 0.08-10 mg, of cinobufagin and resibufogenin, and the package difference limit is smaller than or equal to + / -15% according to the net weight, being 1-100 mg, of arenobufagin in the single-dosage package. The small-package arenobufagin is suitable for traditional Chinese medicine decoctions, pills and powder and suitable for external application. By means of the low-temperature drying, particularly freezing drying technology, active components of arenobufagin are kept to the maximum extent; by strictly controlling the total amount of cinobufagin and resibufogenin in the single-dosage package, the use safety problem of arenobufagin is effectively solved, and the last barrier is broken for clinical application of arenobufagin.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a single-dose packaged toad venom with advanced technology, stable quality, precise dosage and safe use and a preparation method thereof. Background technique [0002] Bufonis Venenum is the dry secretion of Bufo melanositictus Schneider or Bufo bufo gargarizans Cantor (Pharmacopoeia of the People's Republic of China, Part I, 2015 Edition). Toad Su is first recorded in the lost Tang Dynasty Materia Medica "Medicine Nature", formerly known as Toad Meizhi. It has detoxification, pain relief, and refreshing effects. It is used to treat carbuncle sores, sore throat, sunstroke, coma, abdominal pain, vomiting and diarrhea due to fever. More into pills and powder. Appropriate amount for external use. [0003] Toad venom contains a large amount of bufadienolide compounds, such as Bufotalin, bufalin, cinobufagin, resibufogenin, etc. They are the main active ing...

AI Technical Summary

Problems solved by technology

However, due to the lack of accurate scales for on-site weighing in clinical applications, the use of Chansu is largely limited to traditional Chinese medicine preparations.

And its method of use has been used until now without any breakthrough, especially not being practically applied in traditional Chinese medicine decoctions. The key factor is the safety problem caused by inaccurate dose control.