Manufacturing method of antibacterial titanium alloy for bio-medical treatment

Abstract

The invention belongs to the field of bio-medical metal materials and particularly relates to a manufacturing method of an antibacterial titanium alloy for bio-medical treatment. A Ti-Al-Fe-Zr-Ag-RE system alpha+beta type two-phase titanium alloy with Ti-5Al-2.5Fe as a basis is prepared through an intermediate alloy, the smelting and production technology of the Ti-Al-Fe-Zr-Ag-RE antibacterial titanium alloy is performed, the Ti-Al-Fe-Zr-Ag-RE antibacterial titanium alloy component range (by weight percent) is provided, titanium alloy theoretical research shows that Al, O and N in the titanium alloy are alpha-phase stable elements, Fe is a beta-phase stable element, Zr is a neutral strengthening element, and the cold and hot processing performance and the plasticity of the titanium alloy are improved; Ag is a co-elution type element, and research at home and abroad shows that silver ions have very strong sterilization performance; a trace of rare earth elements can refine crystalline grains and improve the mechanical performance of the titanium alloy; and multi-element micro-alloy element composite strengthening is the development direction of the titanium alloy.

Description

technical field [0001] The invention belongs to the field of biomedical metal materials, and in particular relates to a method for manufacturing an antibacterial titanium alloy for biomedical use. Background technique [0002] Titanium and its alloys have been more and more widely used clinically due to their elastic modulus similar to that of human bone, good biocompatibility and excellent corrosion resistance in biological environments; titanium and its alloys for biomedical use The development can be divided into three stages, the first stage is represented by pure titanium and Ti-6Al-4V; the second stage is a new type of α+β alloy represented by Ti-5Al-2.5Fe, and Ti-6Al-7Nb; The three stages are an era of developing and developing titanium alloys with better biocompatibility and lower elastic modulus, among which the research on β-type titanium alloys is the most extensive. [0003] Titanium alloys initially used clinically are mainly represented by pure titanium and Ti...

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Problems solved by technology

[0003] Titanium alloys initially used clinically are mainly represented by pure titanium and Ti-6Al-4V; pure titanium has good corrosion resistance in physiological environments, but its strength is low and its wear resistance is poor, which limits its ability to withstand loads. At present, it is mainly used for oral restoration and bone replacement of small parts; Ti-6Al-4V titanium alloy has high strength and good processing performance. This alloy was introduced in the 1970s. It is widely used as a surgical repair material, such as hip and knee joints. It is also used clinically as a replacement material for femur and tibia. However, this type of alloy contains two elements, Al and V, and V is considered to be an element that is toxic to organisms. It accumulates in the bone, liver, kidney, spleen and other organs in the body, and its toxic effects are related to the biochemical metabolism of phosphate; in order to avoid the potential toxicity of V elements, two new α+β-type medical titanium alloys Ti-5Al-2.5 were developed in the mid-1980s. Fe and Ti-6Al-7Nb have been developed in Europe; the mechanical properties of this type of alloy are similar to those of Ti-6Al-4V, and the toxic element V is replaced by Fe and Nb in this type of alloy; in recent years, new medical β-type titanium alloys The research and development mainly use high Mo and high Nb elements to replace V, further reduce the elastic modulus E of titanium alloy, make it close to the elastic modulus of human bone, avoid the occurrence of stress shielding phenomenon and lead to bone resorption around the implant, and finally Cause implant loosening or fracture, resulting in implant failure; however, molybdenum or niobium are refractory metals, which are prone to segregation during the smelting process, which seriously affects the stability of their mechanical properties; molybdenum is also harmful to the human body, and the proportion of the two is large. The weight of its implants is relatively large, so β-type titanium alloys have not been used on a large scale