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Waist-strengthening and kidney-invigorating tablet and preparation method thereof

A technology for strengthening the waist and forming tablets, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problems affecting the quality of preparations, curative effect, unreasonable extraction process, and affecting drug absorption. And other issues

Inactive Publication Date: 2016-07-27
韩志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the extraction process is unreasonable and unscientific, it will inevitably cause damage and loss of active ingredients, thereby affecting the quality and curative effect of the preparation
In addition, the disintegration time of the existing Zhuangyaojianshen tablets is relatively long, especially after long-term storage, it may exceed the pharmacopoeia standard, and the disintegration time is too long, which will seriously affect the absorption of the drug
[0004] With the continuous improvement of clinical requirements on the quality and effect of drugs and the continuous development of pharmaceutical technology, this technology can no longer meet the current needs. There is an urgent need for a preparation technology with more complete extraction of active ingredients and higher content to better exert its strength. Medicinal Value of Classical Prescription of Yaojianshen Tablets

Method used

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  • Waist-strengthening and kidney-invigorating tablet and preparation method thereof
  • Waist-strengthening and kidney-invigorating tablet and preparation method thereof
  • Waist-strengthening and kidney-invigorating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112]

[0113]

[0114] Wash 1 / 2 of the dog's spine, 1 / 2 of the black tiger, golden cherry and Niu Dali respectively, soak in 3 times the amount of water for 10 hours, remove it, and dry the water to keep the surface of the Chinese herbal medicine dry. After being frozen at -20°C for 2 hours, carry out ultrafine pulverization in an environment of -6°C to obtain ultrafine powder; after ultrafine pulverization, 90%-95% of the fine powder particle size is 4-6 microns; the remaining 1 / 2 amount Soak the dog ridge with 8 times the amount of water for 30 minutes, add 12g of compound enzyme, the compound enzyme is 3:1 α-amylase and protein phosphatase, first carry out enzymolysis at 40°C for 30 minutes, and then decoct , decocted for 3 hours for the first time, filtered to obtain the filtrate, decocted the dregs with 6 times the amount of water for 2 hours, filtered to obtain the filtrate, combined the two filtrates, filtered, concentrated the filtrate to 80°C and measured the r...

Embodiment 2

[0116]

[0117] Wash 1 / 2 of the dog's spine, 1 / 2 of the black tiger, golden cherry and Niu Dali respectively, soak in 3 times the amount of water for 10 hours, remove it, and dry the water to keep the surface of the Chinese herbal medicine dry. After being frozen at -20°C for 2 hours, carry out ultrafine pulverization in an environment of -6°C to obtain ultrafine powder; after ultrafine pulverization, 90%-95% of the fine powder particle size is 4-6 microns; the remaining 1 / 2 amount Soak the dog ridge with 8 times the amount of water for 30 minutes, add 12g of compound enzyme, the compound enzyme is 3:1 α-amylase and protein phosphatase, first carry out enzymolysis at 40°C for 30 minutes, and then decoct , decocted for 3 hours for the first time, filtered to obtain the filtrate, decocted the dregs with 6 times the amount of water for 2 hours, filtered to obtain the filtrate, combined the two filtrates, filtered, concentrated the filtrate to 80°C and measured the relative dens...

Embodiment 3

[0119]

[0120] Wash 1 / 2 of the dog's spine, 1 / 2 of the black tiger, golden cherry and Niu Dali respectively, soak in 3 times the amount of water for 10 hours, remove it, and dry the water to keep the surface of the Chinese herbal medicine dry. After being frozen at -20°C for 2 hours, carry out ultrafine pulverization in an environment of -6°C to obtain ultrafine powder; after ultrafine pulverization, 90%-95% of the fine powder particle size is 4-6 microns; the remaining 1 / 2 amount Soak the dog ridge with 8 times the amount of water for 30 minutes, add 12g of compound enzyme, the compound enzyme is 3:1 α-amylase and protein phosphatase, first carry out enzymolysis at 40°C for 30 minutes, and then decoct , decocted for 3 hours for the first time, filtered to obtain the filtrate, decocted the dregs with 6 times the amount of water for 2 hours, filtered to obtain the filtrate, combined the two filtrates, filtered, concentrated the filtrate to 80°C and measured the relative dens...

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Abstract

The invention discloses a waist-strengthening and kidney-invigorating tablet and a preparation method thereof. The waist-strengthening and kidney-invigorating tablet is prepared from rhizoma cibotii, a root of scarlet kadsura, a philippine flemingia root, herba taxilli, caulis spatholobi, fructus rosae laevigatae, fructus ligustri lucidi, radix millettia speciosae and semen cuscutae. The preparation method of the waist-strengthening and kidney-invigorating tablet provided by the invention comprises the following steps of super-finely grinding a half amount of the rhizoma cibotii, a half amount of the root of scarlet kadsura, the fructus rosae laevigatae and the radix millettia speciosae into fine powder respectively, carrying out enzymolysis on the rest half amount of the rhizoma cibotii, the rest half amount of the root of scarlet kadsura and the caulis spatholobi by using a compound enzyme, then decocting an obtained mixture, and carrying out supercritical extraction on rest bulk drugs. The waist-strengthening and kidney-invigorating tablet and the preparation method have the advantages that a proper amount of a disintegrating agent is also added according to an improved process of the waist-strengthening and kidney-invigorating tablet and the preparation method thereof; after the disintegrating agent is added, the prepared tablet is short in disintegration time. By using a process of the waist-strengthening and kidney-invigorating tablet and the preparation method thereof, active ingredients of the waist-strengthening and kidney-invigorating tablet are not destroyed; active ingredients of extracted medicines are more complete; the dissolution rate of a medical product is high; the retention time of a pharmacodynamic effect is long; the bioavailability is high; further, the stability is better. According to the method, an extract is purified; a curative effect is also obviously increased in comparison with a conventional process.

Description

technical field [0001] The invention relates to a medicinal preparation in the medical field, in particular to a Zhuangyaojianshen tablet and a preparation method thereof. Background technique [0002] Zhuangyao Jianshen Tablets are listed in the Chinese Pharmacopoeia. It is prepared from Gouji, Black Tiger, Qianjinba, Sangjisheng, Spatholobi, Rosa, Ligustrum lucidum, Niu Dali and Cuscuta. It has the functions of strengthening waist and kidney, nourishing blood, and expelling rheumatism. It is used to treat kidney deficiency Low back pain, weak knees, neurasthenia, frequent urination, nocturnal emission, premature ejaculation, or rheumatic bone pain. [0003] At present, the preparation process of Zhuangyao Jianshen Tablets basically follows the traditional process method, and the skin of some black tigers is pulverized into coarse powder, and the remaining black tigers and other eight flavors are decocted and extracted. Due to the open type pulverization of ordinary pulve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61K36/79A61K9/28A61K47/32A61K47/02A61P13/12A61P15/00A61P13/00A61P19/08A61P29/00
CPCA61K36/11A61K9/2009A61K9/2027A61K9/28A61K36/185A61K36/39A61K36/48A61K36/486A61K36/57A61K36/638A61K36/738A61K36/79A61K2236/19A61K2236/331A61K2236/37A61K2236/39A61K2236/53
Inventor 韩志强
Owner 韩志强
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