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Active polysaccharide composite bone repair material

A technology of active polysaccharides and composite materials, which is applied in the intersection of materials science and biomedicine, can solve the problems of difficulty in shaping and cannot be degraded in the body, and achieve the effect of increasing antibacterial properties, increasing the ability to form pores, and having no cytotoxicity.

Active Publication Date: 2019-03-19
ZHEJIANG RISING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the biocompatibility of hydroxyphosphate ceramics is good, its clinical application is limited due to its difficulty in shaping and inability to degrade in vivo.

Method used

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  • Active polysaccharide composite bone repair material
  • Active polysaccharide composite bone repair material

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0030] Take 40% of calcium hydrogen phosphate, 35% of tetracalcium phosphate, 15% of chitosan, 8% of sodium dihydrogen phosphate, and 2% of hypromellose and mix them into powder A bottle according to the ratio of mannitol (w / w): MES aqueous solution (mmol / L): rhBMP-2 (mg / ml) = 1%: 50: 0.3, freeze-dried after preparation to become bottle B.

[0031] After dissolving bottle A with 2ml of water for injection, fully reconcile with bottle B containing 0.5g of material, make it into a cylindrical shape, and place it for 10 minutes. After the material is hydrated and hardened, implant it into the mouse muscle bag, and add a small amount of antibiotics Afterwards, sew the whole mouse. After 21 days of normal feeding, they were taken out at the implantation site. Observation of slices revealed osteocyte formation.

[0032] Dissolve bottle A with 2ml of water for injection, make it into a cylindrical shape, and place it for 10 minutes. After the material is hydrated and hardened, imp...

Embodiment 2

[0034] Take 45% of calcium hydrogen phosphate, 30% of tetracalcium phosphate, 15% of chitosan, 5% of sodium dihydrogen phosphate, and 5% of hypromellose and mix them into powder A bottle according to the ratio of mannitol (w / w): MES aqueous solution (mmol / L): rhBMP-2 (mg / ml) = 5%: 40: 0.5, freeze-dried after preparation to become bottle B.

[0035] After dissolving A with 3ml of water for injection, fully reconcile it with bottle B containing 0.75g of material, make it into a cylindrical shape, and place it for 10 minutes. After the material is hydrated and hardened, implant it into the rat muscle bag, and add a small amount of antibiotics. , Sew the whole rat. After 21 days of normal feeding, they were taken out at the implantation site. It was found that there was bone tissue, and after sectioning and staining, it was found that there were osteocytes.

[0036] Dissolve bottle A with 3ml of water for injection, make it into a cylindrical shape, and place it for 10 minutes....

example 3

[0038]Take 50% of calcium hydrogen phosphate, 30% of tetracalcium phosphate, 10% of chitosan, 7% of sodium dihydrogen phosphate, and 3% of hypromellose and mix them into powder A bottle according to the ratio of mannitol (w / w): MES aqueous solution (mmol / L): rhBMP-2 (mg / ml) = 6%: 35: 0.6, freeze-dried after preparation to become bottle B.

[0039] After dissolving bottle A with 2ml of water for injection, fully reconcile with bottle B containing 0.5g of material, make it into a cylindrical shape, and place it for 10 minutes. After the material is hydrated and hardened, implant it into the mouse muscle bag, and add a small amount of antibiotics Afterwards, sew the whole mouse. After 21 days of normal feeding, they were taken out at the implantation site. Observation of slices revealed osteocyte formation.

[0040] Dissolve bottle A with 2ml of water for injection, make it into a cylindrical shape, and place it for 10 minutes. After the material is hydrated and hardened, impl...

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PUM

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Abstract

The invention discloses an active polysaccharide composite bone repair material which is good in biocompatibility, good in plasticity, certain in mechanical strength and moderate in degradation velocity in bodies and can meet clinical requirements. The active polysaccharide composite bone repair material comprises a bottle A and a bottle B, wherein the bottle A comprises powder of tetracalcium phosphate, calcium hydrophosphate, chitosan, monosodium phosphate and hydroxypropyl methylcellulose; the bottle B comprises mannitol, an MES solution and a rhBMP-2 biological active factor freeze-dried aquatic product. The active polysaccharide composite bone repair material can induce formation of new bone in a human body, can form active tissue, has the advantages of good compatibility, plasticity and the like, is free of toxic reaction and can be tightly connected with sclerotin after being cured.

Description

technical field [0001] The invention belongs to the intersection field of material science and biomedicine, and relates to an active polysaccharide composite bone repair material that can be used as filling, repairing and replacing human bone tissue. Background technique [0002] In the field of orthopedics, bone transplantation is mainly used to repair bone defects, nonunions and other operations caused by trauma, tumors, inflammation and various deformities. Bone repair is a long-term unresolved problem in the field of orthopedics. Currently, the clinical treatment of bone defects, nonunions, and delayed fracture unions is mainly done through bone transplantation, including autologous bone transplantation, allogeneic bone transplantation, organic polymeric bone cement and biological ceramics etc. [0003] Autologous bone grafting is the grafting of bone from one part of the body to another part of the body. Autogenous bone is most commonly obtained from the ilium, tibia,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61L27/56A61L27/54A61L27/20A61L27/12A61L27/22A61L27/50
CPCA61L27/12A61L27/20A61L27/227A61L27/50A61L27/54A61L27/56A61L2300/252A61L2300/412A61L2430/02C08L5/08C08L1/284C08L89/00
Inventor 曹建新
Owner ZHEJIANG RISING BIOTECH CO LTD
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